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First CRISPR/Cas9 screen helps identify human proteins required for Zika virus replication

Scientists at the University of Massachusetts Medical School have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication.

22 Jun 2016

SORLA protein makes fat cells oversensitive to insulin

SORLA is a protein that influences the balance of metabolic processes in adipose tissue, a particular form of fat. Too much of it makes fat cells overly sensitive to insulin, which leads them to break down less fat. SORLA was previously known for its protective role in Alzheimer's disease.

22 Jun 2016

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Researchers from the University of Chicago have shown that microbiota—the bacteria, viruses and other microbes living on the skin and in the digestive system—play an important role in the body's ability to accept transplanted skin and other organs.

22 Jun 2016

Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Chronic pain is one of the most prevalent, disabling and expensive public health crises in the United States. It affects more than 100 million Americans, with annual costs estimated at $635 billion, says a 2014 report from the American Pain Society.

22 Jun 2016

Insilico Medicine collaborates with Asia Genomics to develop advanced personalized longevity suite

Insilico Medicine Inc, a big data analytics company located at the Emerging Technology Centers at the Johns Hopkins University at Eastern, announced an agreement with Asia Genomics, a Singapore-based rapidly growing molecular diagnostics company specializing in clinical genomics & genetic testing operating in major Asian countries including Vietnam, Malaysia and China.

22 Jun 2016

New CAR-based therapy using combined cancer target could be effective for solid tumors

Chimeric antigen receptors (CARs), engineered from a patient's own immune cells, have been successful for treating blood cancers, but using CARs for solid tumors has been limited by side effects to normal tissues containing the protein targeted by the engineered cells.

22 Jun 2016

Researchers play crucial role in crafting diagnostic criteria for functional GI disorders

With no laboratory test available to diagnose functional gastrointestinal disorders, proper diagnostic criteria are critical for clinicians to make an accurate determination of what ails their patients.

22 Jun 2016

Inflammatory response to mosquito bites can help spread viral infections

Mosquito bite sites are not just itchy, irritating nuisances - they also make viral infections spread by the insects far worse, new research has found.

22 Jun 2016

New study reveals conversion of oral cannabidiol to THC by acidic fluids in the stomach

A new study demonstrating the conversion of oral cannabidiol (CBD) to the psychoactive component tetrahydrocannabinol (THC) in the presence of gastric fluids could explain why children given CBD to treat epilepsy had an unexpectedly high rate of adverse effects such as sleepiness and fatigue.

22 Jun 2016

VUMC researchers aim to decode genetic underpinnings of human immune system

Researchers at Vanderbilt University Medical Center this month began recruiting volunteers to participate in a clinical trial aimed at decoding the human "immunome," the genetic underpinnings of the immune system.

22 Jun 2016

Molecular map of transporter proteins could be vital step toward drug discovery against zinc-related diseases

Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.

21 Jun 2016

Cardiac surgery patients who received omega-3 supplementation experience reduced hospital stays

A new meta-analysis published in Clinical Nutrition found that cardiac surgery patients who received omega-3 polyunsaturated fatty acids (compared to placebo) in advance of surgery experienced reduced postoperative cardiac arrhythmias and significantly reduced the length of hospital stay by up to 2.4 days. The results are based on 11 RCT's with 1038 patients.

21 Jun 2016

Experts use next-generation genetic sequencing to diagnose suspected brain infections

In a proof-of-principle study, a team of physicians and bioinformatics experts at Johns Hopkins reports they were able to diagnose or rule out suspected brain infections using so called next-generation genetic sequencing of brain tissue samples.

21 Jun 2016

Clinical trial finds pioglitazone drug safe and effective for NASH patients

Researchers have found that an existing diabetes drug can be used to halt progression of another disease that is a leading cause of liver transplants.

21 Jun 2016

Experts develop set of resolutions, conclusions to provide clarity on testosterone therapy

In an effort to address widespread concerns related to testosterone deficiency (TD) and its treatment with testosterone therapy, a group of international experts has developed a set of resolutions and conclusions to provide clarity for physicians and patients.

21 Jun 2016

Certain leisure activities may lower risk of post-operative delirium in older adults

Delirium, or the medical term for experiencing sudden confusion, is upsetting for both older adults and their families. In fact, it is one of the most common complications older adults face after surgery (a time often referred to as the "post-operative" period).

21 Jun 2016

New Aspirin-Guide mobile app helps clinicians and patients make informed decisions about aspirin use

Low dose aspirin is recommended by clinicians as a preventive measure for patients who have already had a heart attack or stroke, but the risk of taking low-dose aspirin to prevent or delay a first heart attack or stroke is less clear, as the benefit for reducing the risk of cardiovascular disease (CVD) must be balanced with the increased risk of gastrointestinal or other bleeding.

21 Jun 2016

Mayo Clinic highlights potential merits of individualizing treatment for patients taking antidepressants

Mayo Clinic is highlighting the potential merits of using precision medicine in prescribing antidepressants. Details appear in the current issue of Mayo Clinic Proceedings.

21 Jun 2016

Kidney transplant recipients with inflammation prior to surgery more likely to develop diabetes

Up to 30 percent of people who receive organ transplants will develop diabetes, but researchers are unsure why. Although doctors typically blame immunosuppressive drugs that transplant recipients take to prevent organ rejection, it's unclear why some people develop the lifelong disorder, while others do not.

21 Jun 2016

Researchers identify 38 independent genomic regions linked to migraine

The results of the largest genetic study on migraine thus far were published online in the journal Nature Genetics today, June 20. The study was based on DNA samples of 375,000 European, American and Australian participants. Almost 60,000 of them suffer from migraine.

21 Jun 2016

Medicine News and Research

First CRISPR/Cas9 screen helps identify human proteins required for Zika virus replication

SORLA protein makes fat cells oversensitive to insulin

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Insilico Medicine collaborates with Asia Genomics to develop advanced personalized longevity suite

New CAR-based therapy using combined cancer target could be effective for solid tumors

Researchers play crucial role in crafting diagnostic criteria for functional GI disorders

Inflammatory response to mosquito bites can help spread viral infections

New study reveals conversion of oral cannabidiol to THC by acidic fluids in the stomach

VUMC researchers aim to decode genetic underpinnings of human immune system

Molecular map of transporter proteins could be vital step toward drug discovery against zinc-related diseases

Cardiac surgery patients who received omega-3 supplementation experience reduced hospital stays

Experts use next-generation genetic sequencing to diagnose suspected brain infections

Clinical trial finds pioglitazone drug safe and effective for NASH patients

Experts develop set of resolutions, conclusions to provide clarity on testosterone therapy

Certain leisure activities may lower risk of post-operative delirium in older adults

New Aspirin-Guide mobile app helps clinicians and patients make informed decisions about aspirin use

Mayo Clinic highlights potential merits of individualizing treatment for patients taking antidepressants

Kidney transplant recipients with inflammation prior to surgery more likely to develop diabetes

Researchers identify 38 independent genomic regions linked to migraine

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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