Immune Response News and Research

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Nasal vaccine effective in preventing COVID-19 infection in mice

Scientists at Washington University School of Medicine in St. Louis have developed a vaccine that targets the SARS-CoV-2 virus, can be given in one dose via the nose and is effective in preventing infection in mice susceptible to the novel coronavirus.

21 Aug 2020

Study offers insights into immune reactions in severe COVID-19

Researchers may have come one step closer toward understanding how the immune system contributes to severe COVID-19.

21 Aug 2020

Researchers find clues to successful immune response in the T cells of COVID-19 patients

When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells and their role in HIV spread and long-lasting infections.

21 Aug 2020

Study: Many COVID-19 patients suffer cardiovascular damage even after recovery

One of the most harrowing effects of COVID-19 is severe damage to the lungs, which makes breathing hard or impossible for those who're severely affected.

21 Aug 2020

Macaques show low neutralizing antibody and cellular immune response to SARS-CoV-2

A new study published on the preprint server bioRxiv* in August 2020 presents a cynomolgus macaque model that develops symptomatic SARS-CoV-2 infection in a mild form, with low or no antibody responses, making it suitable to study human responses to vaccines and drugs targeting the virus.

21 Aug 2020

Bioinformatics identifies key genes and cellular pathways in COVID-19

The COVID-19 pandemic is showing no signs of waning or extinction anytime soon. Now, a new study published on the preprint server bioRxiv* in August 2020 shows a new bioinformatics approach to studying the pathogenesis of this disease, by uncovering the differentially expressed genes (DEGs) and cell signaling pathways that cause the disease characteristics. This will help develop better therapies to counter the effects of these genes.

20 Aug 2020

COVID-19 could compromise key element of immune response

Researchers at the University of Melbourne have made the unsettling discovery that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might compromise the activation of the CD8+ T-cell responses that would usually ameliorate disease and drive recovery in cases of respiratory disease.

20 Aug 2020

A metabolic enzyme shows great potential as target for immunotherapies

The metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system.

20 Aug 2020

Children play a larger role in the community spread of COVID-19 than previously thought

In the most comprehensive study of COVID-19 pediatric patients to date, Massachusetts General Hospital (MGH) and Mass General Hospital for Children (MGHfC) researchers provide critical data showing that children play a larger role in the community spread of COVID-19 than previously thought

20 Aug 2020

Canadian Coalition for COVID-19 releases 51 promising nanobodies

A group of Canadian companies has published 51 antibodies that show promising ability to bind the COVID-19 virus which could result in neutralizing the virus.

From SignalChem Biotech Inc. 20 Aug 2020

Inhibition of key receptor implicated in post-stroke damage and recovery

Many people who suffer a stroke are permanently disabled. Stroke remains the leading cause of long-term disability in the United States.

20 Aug 2020

Researchers develop vaccine for human herpesvirus 6B

A research group led by Professor MORI Yasuko (of the Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine) has revealed that the HHV-6B glycoprotein complex gH/gL/gQ1/gQ2 is an effective vaccine candidate for human herpesvirus 6B (HHV-6B).

20 Aug 2020

Researchers identify mechanism that explains lower-quality immune response in COVID-19 patients

The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.

20 Aug 2020

Cytokine storms may prevent the development of long-term immunity to SARS-CoV-2

Shiv Pillai, MD, PhD, investigator in the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School (HMS), recently published a paper in Cell showing that that high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

19 Aug 2020

Centralized medical records repository can perform data analysis and visualization

More than a decade ago, electronic medical records were all the rage, promising to transform health care and help guide clinical decisions and public health response.

19 Aug 2020

Mathematical modeling helps researchers track and tackle COVID-19 pandemic

The Editor-in-Chief Vitaly Volpert of the Institut Camille Jordan, University ofLyon, France, reviews how the public's new favourite scientific discipline, mathematical modelling, is being used to track and tackle the COVID-19 pandemic.

19 Aug 2020

Single-dose adenovirus-vectored vaccine protects mice against SARS-CoV-2

The researchers selected the human adenovirus type 5 on which to base their vaccine because this replication-defective vector had already been used in their Ebola vaccine, with an excellent safety and immunogenicity profile in a phase 1 trial. The current study aimed to produce a vaccine that could offer mucosal vaccination and enhanced protection against this respiratory virus.

19 Aug 2020

Structural analysis of SARS-CoV-2 can help develop COVID-19 vaccines

At the start of a COVID-19 infection, the coronavirus SARS-CoV-2 docks onto human cells using the spike-like proteins on its surface.

19 Aug 2020

Large SARS-CoV-2 outbreak on a fishing boat - neutralizing antibodies prevent infection

Now, a team of researchers at the University of Washington School of Medicine has found evidence that SARS-CoV-2 neutralizing antibodies can prevent infection in people, as they conducted a study before and after a COVID-19 outbreak on a fishing vessel.

19 Aug 2020

Acidic niche within lymph nodes plays integral role in regulating T cell activation

In the fight against cancer, the immune system is the first line of defense. The lymphatic system specifically is essential to protecting the body against foreign invaders.

19 Aug 2020