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Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

It has long been known that astrocytes change their shapes as a consequence of Alzheimer's. Cells located near the "plaques", as the protein deposits typical for this disease are called, grow in size and form additional extensions.

20 Nov 2014

A new formal protocol for emergency treatment of patients with aneurysmal SAH

Neurosurgeons and neurointerventionalists at Kyungpook National University in the Republic of Korea have developed a formal protocol for delivering emergency treatment to patients with subarachnoid hemorrhage (SAH) from ruptured aneurysms within the first few hours after bleeding occurs.

20 Nov 2014

Changes in one gene can influence person's cholesterol levels from midlife through late life

It's known that cholesterol levels typically rise as people age and that high cholesterol levels are associated with increased risk of cardiovascular disease. What's less known is that cholesterol levels begin to decline the more a person ages. Recently, researchers from the University of Texas Medical Branch at Galveston and the University of Kentucky found that differences in one gene can influence a person's cholesterol levels from midlife to late life.

19 Nov 2014

Leaders in research hope to uncover promising drugs in pharma libraries, conduct clinical trials

Drugs for brain diseases such as Alzheimer's, Parkinson's, and motor neurone disease that have stalled in development could be revived thanks to the efforts of a global coalition of non-profit organizations and funders announced today.

19 Nov 2014

New study identifies crizotinib drug as possible new coating for drug-eluting stents

A new study has identified an FDA approved cancer drug, crizotinib, as a possible new coating for drug-eluting stents. Researchers found that crizotinib in mice helped prevent the narrowing of blood vessels after stenting without affecting the blood vessel lining.

19 Nov 2014

Cardiac stem cell treatment restores heart function damaged by Duchenne muscular dystrophy

Researchers at the Cedars-Sinai Heart Institute have found that injections of cardiac stem cells might help reverse heart damage caused by Duchenne muscular dystrophy, potentially resulting in a longer life expectancy for patients with the chronic muscle-wasting disease.

18 Nov 2014

VEGF-B can regenerate damaged peripheral nerves without causing growth of new blood vessels

Researchers at the University of Illinois at Chicago College of Medicine have found that a growth factor can regenerate damaged peripheral nerves without causing the growth of new blood vessels -- making it a unique candidate to treat nerve damage in areas of the body where the proliferation of blood vessels would be a drawback.

18 Nov 2014

Simple tests can help differentiate between early-stage PD and atypical parkinsonism

Two simple tests conducted during the neurological exam can help clinicians differentiate between early-stage Parkinson's disease (PD) and atypical parkinsonism. By asking patients to perform a tandem gait test and inquiring whether they are still able to ride a bicycle, clinicians can ascertain whether medio-lateral balance is impaired, a defining characteristic of atypical parkinsonism.

18 Nov 2014

Experts focus on key issues impeding delivery of cardiac care in resource-limited settings

Critical care is defined by life-threatening conditions, which require close evaluation, monitoring, and treatment by appropriately trained health professionals. Cardiovascular care bears these same requirements.

14 Nov 2014

University at Buffalo researchers receive $500,000 grant to study IED-induced vision loss

It's well known that battlefield explosions can cause hearing loss, but veterans may be surprised to learn that their vision may also suffer — sometimes weeks or months after combat exposure.

14 Nov 2014

Impaired brain circulation in African Americans can increase risk of cerebrovascular disease

Researchers at The University of Texas have found that compared to Caucasian Americans, African Americans have impaired blood flow regulation in the brain that could contribute to a greater risk of cerebrovascular diseases such as stroke, transient ischaemic attack ("mini stroke"), subarachnoid haemorrhage or vascular dementia.

14 Nov 2014

Estrogen plays key role in regulating blood pressure, LDL cholesterol levels

What makes some women more susceptible to heart disease than others? To help answer that question, researchers at Western University's Robarts Research Institute have identified that an estrogen receptor, previously shown to regulate blood pressure in women, also plays an important role in regulating low-density lipoprotein (LDL) cholesterol levels.

13 Nov 2014

Toxicity profiles for everolimus, temsirolimus differ in advanced RCC

Non-infectious pneumonitis and stomatitis occur more frequently in patients with advanced renal cell carcinoma treated with everolimus than temsirolimus, whereas temsirolimus is associated with a higher incidence of fatigue, rash and asthenia, a retrospective study reports.

13 Nov 2014

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Bevacizumab may enhance the antitumour activity of erlotinib by increasing the intratumoural concentration of erlotinib in some non-small-cell lung cancers expressing high levels of vascular endothelial growth factor, Japanese researchers report.

13 Nov 2014

Study: Fast-food outlets in inner city neighborhoods linked to risk of diabetes, obesity

How close you are to fast-food outlets may be linked to your risk of Type-2 diabetes and obesity a new study led by the University of Leicester has discovered.

12 Nov 2014

Rose Medical Center becomes first hospital in Colorado to perform new procedure for PAD patients

Rose Medical Center is the first hospital in Colorado to perform a new and innovative procedure for patients with peripheral arterial disease (PAD). Utilizing the Lutonix 035 Drug Coated Balloon PTA Catheter, surgeons are able to perform a balloon angioplasty in patients with PAD using a special drug-coated balloon (DCB) that delivers a small amount of medication to the inside walls of the diseased portion of the artery.

12 Nov 2014

Study: Heart attack, stroke survivors' physical limitations rapidly increase over decade

A record number of people are surviving heart attacks and stroke but those who do may experience a sharp decline in physical abilities that steadily accelerates over time, according to a new nationally-representative study led by the University of Michigan.

12 Nov 2014

Endothelin gene expression linked to vision loss in premature babies

A gene known to play a major role in constricting blood vessels also appears to be a major player in the aberrant blood vessel growth that can destroy the vision of premature babies.

11 Nov 2014

New treatment could halt growth of tumours in prostate cancer patients

Scientists believe a new treatment, shown to be effective in mice, could halt the growth of tumours in patients with prostate cancer.

11 Nov 2014

New model explains how immune cells recognize, destroy bacteria

The innate immune system serves as the body's specialized armed forces division, comprised of a host of defense mechanisms used to battle bacterial infections. Among the system's warriors are white blood cells including the specialized macrophages, which maintain constant surveillance for foreign intruders or pathogens, functioning as the body's first line of defense, poised to attack at barrier sites including the skin, lungs and intestines.

11 Nov 2014

Vascular News and Research

Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

A new formal protocol for emergency treatment of patients with aneurysmal SAH

Changes in one gene can influence person's cholesterol levels from midlife through late life

Leaders in research hope to uncover promising drugs in pharma libraries, conduct clinical trials

New study identifies crizotinib drug as possible new coating for drug-eluting stents

Cardiac stem cell treatment restores heart function damaged by Duchenne muscular dystrophy

VEGF-B can regenerate damaged peripheral nerves without causing growth of new blood vessels

Simple tests can help differentiate between early-stage PD and atypical parkinsonism

Experts focus on key issues impeding delivery of cardiac care in resource-limited settings

University at Buffalo researchers receive $500,000 grant to study IED-induced vision loss

Impaired brain circulation in African Americans can increase risk of cerebrovascular disease

Estrogen plays key role in regulating blood pressure, LDL cholesterol levels

Toxicity profiles for everolimus, temsirolimus differ in advanced RCC

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Study: Fast-food outlets in inner city neighborhoods linked to risk of diabetes, obesity

Rose Medical Center becomes first hospital in Colorado to perform new procedure for PAD patients

Study: Heart attack, stroke survivors' physical limitations rapidly increase over decade

Endothelin gene expression linked to vision loss in premature babies

New treatment could halt growth of tumours in prostate cancer patients

New model explains how immune cells recognize, destroy bacteria

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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