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Loss of HOXA5 protein may allow breast cancer cells to thrive

Many breast cancers are marked by a lack of HOXA5 protein, a gene product known to control cell differentiation and death, and lower levels of the protein correspond to poorer outcomes for patients.

20 May 2016

Radiation-immunotherapy combination can help treat melanoma

Combining radiation treatments with a new generation of immunotherapies is showing promise as a one-two-punch against melanoma, Loyola Medicine researchers report in a review article.

20 May 2016

Study finds that ACS NSQIP Surgical Risk Calculator has excellent calibration

The American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator accurately estimates the chance of a patient experiencing postoperative complications, and its performance can improve with recalibration of the tool according to research findings appearing online in the Journal of the American College of Surgeons in advance of print publication.

20 May 2016

Borrowed immune system may help combat cancer

A new step in cancer immunotherapy: researchers from the University of Oslo/Oslo University Hospital and the Netherlands Cancer Institute show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.

20 May 2016

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

Maternal pregabalin exposure linked to major birth defect risk

First trimester exposure to pregabalin may be associated with an increased risk of major birth defects, an observational study suggests.

19 May 2016

SUSTAIN study to test effect of high-dose selenium on recovery of cardiac surgery patients

Queen's University researcher Daren Heyland is leading a study that aims to reduce the risk of complications and improves recovery of cardiac surgery patients.

19 May 2016

UK's first heart operation uses new Topera system to analyse electrical activity during AF

The UK's first heart operations using a novel software platform to pinpoint the source of the heart condition have been carried out in Leicester thanks to research at the University of Leicester.

19 May 2016

Combining 2-DG with fenofibrate could provide non-toxic treatments for many cancers

A team of researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine recently discovered a novel, non-toxic approach to treating a wide variety of cancers.

19 May 2016

Neuropeptide plays role in driving rhythms of detoxification gene activity, study shows

A 24-hour rhythm of cellular detoxification in flies and mammals is coordinated by a neuropeptide that also drives feeding in both organisms, found a team led by Amita Sehgal, PhD, a professor of Neuroscience and director of the Chronobiology Program, in the Perelman School of Medicine at the University of Pennsylvania.

19 May 2016

Simple sarcopenia screening method could easily diagnose severity of heart disease

Researchers from Kumamoto University in Japan have shown that a simple screening method could quickly and easily diagnose the severity of heart disease. The method was originally developed to diagnose sarcopenia, a disease that causes a loss of muscle mass and strength.

19 May 2016

New autism classification system defines social communication ability levels among ASD children

Children with autism have a wide range of ability to talk with other people, but it has been difficult to group children by their specific skills.

19 May 2016

MERS individuals develop severe critical illness, higher mortality than non-MERS SARI patients

Patients with Middle East Respiratory Syndrome (MERS) develop more severe critical illness and have higher mortality than patients with non-MERS severe acute respiratory infection (SARI), according to investigators involved with the largest study of critically ill patients with MERS.

19 May 2016

Penn State researchers link mutation in common virus to fatal brain disease

Why people on immunosuppressant drugs for autoimmune conditions have a higher incidence of an often-fatal brain disease may be linked to a mutation in a common virus, according to researchers at Penn State College of Medicine.

19 May 2016

Higher adolescent intake of saturated fat linked to higher dense breast volume in early adulthood

Consuming high amounts of saturated fat or low amounts of mono- and polyunsaturated fats as an adolescent was associated with higher breast density in young adulthood. Breast density is a risk factor for breast cancer.

19 May 2016

Experts find vast mental health treatment gap in China and India

A third of the global burden of disease for mental, neurological and substance use disorders occurs in India and China – more than in all high-income countries combined – yet most people with mental disorders in these countries do not receive needed treatment.

19 May 2016

New lab blood test may help identify HELLP syndrome in pregnant women

A laboratory blood test developed at Johns Hopkins for the diagnosis of a rare genetic red blood cell disorder also shows promise in identifying HELLP syndrome, a life-threatening high blood pressure condition affecting 1 percent of all pregnant women that causes hypertension along with end organ damage, researchers report in the May issue of the journal Experimental Hematology.

19 May 2016

Flavopiridol drug could be effective strategy to impair brain cancer growth

Glioblastoma, the most common form of brain cancer is a deadly disease for which at present there is no cure. Now, researchers have published research results that show how repurposing the old drug flavopiridol could be an effective strategy to cut short sugar availability and impair cancer growth.

19 May 2016

Hydroxyurea treatment improves pulmonary function decline in children with sickle cell disease

For the first time, researchers were able to demonstrate that children diagnosed with sickle cell disease showed improvement in lung function after treatment with hydroxyurea, a treatment that is underused despite its demonstrated benefits.

19 May 2016

Insilico Medicine collaborates with National Laboratory Astana to study age-related pathologies

Insilico Medicine announced an agreement with National Laboratory Astana, Nazarbayev University, one of the most rapidly growing universities in the world to collaboratively study aging and age-associated pathologies.

19 May 2016

Medicine News and Research

Loss of HOXA5 protein may allow breast cancer cells to thrive

Radiation-immunotherapy combination can help treat melanoma

Study finds that ACS NSQIP Surgical Risk Calculator has excellent calibration

Borrowed immune system may help combat cancer

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Maternal pregabalin exposure linked to major birth defect risk

SUSTAIN study to test effect of high-dose selenium on recovery of cardiac surgery patients

UK's first heart operation uses new Topera system to analyse electrical activity during AF

Combining 2-DG with fenofibrate could provide non-toxic treatments for many cancers

Neuropeptide plays role in driving rhythms of detoxification gene activity, study shows

Simple sarcopenia screening method could easily diagnose severity of heart disease

New autism classification system defines social communication ability levels among ASD children

MERS individuals develop severe critical illness, higher mortality than non-MERS SARI patients

Penn State researchers link mutation in common virus to fatal brain disease

Higher adolescent intake of saturated fat linked to higher dense breast volume in early adulthood

Experts find vast mental health treatment gap in China and India

New lab blood test may help identify HELLP syndrome in pregnant women

Flavopiridol drug could be effective strategy to impair brain cancer growth

Hydroxyurea treatment improves pulmonary function decline in children with sickle cell disease

Insilico Medicine collaborates with National Laboratory Astana to study age-related pathologies

Everything there is to know about biosimilars eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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