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Study evaluates long-term outcomes of TAVR with SAPIEN 3 in intermediate-risk patients

To account for baseline differences, TAVR patients were compared by a propensity score analysis with patients randomized to receive surgical intervention in a precursor study, PARTNER 2A. Propensity scoring analysis is a statistical technique used to reduce bias from potential confounding variables, which in this case was used to identify surgical patients from a previous study who would be comparable to TAVR patients in this study.

4 Apr 2016

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

Society of Interventional Radiology honors outstanding achievers with annual awards

Renan Uflacker, M.D., FSIR, was honored posthumously on April 3 with the Society of Interventional Radiology Foundation Leaders in Innovation Award. The award was announced during the Society of Interventional Radiology's Annual Scientific Meeting in Vancouver, British Columbia.

4 Apr 2016

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

In the first major trial of its kind, Cleveland Clinic researchers used a blinded rechallenge with atorvastatin or placebo to objectively confirm the presence of muscle-related symptoms in patients with a history of intolerance to multiple statins and found that evolocumab (a PCSK9 inhibitor) was a more effective option to lower cholesterol than ezetimibe in these patients.

4 Apr 2016

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Findings from the early phase of a clinical trial led by Johns Hopkins investigators indicates that a new, minimally invasive weight loss treatment known as bariatric arterial embolization is safe and effective in sustaining weight loss in severely obese people.

4 Apr 2016

Patient-oriented tool helps shared decision-making between patients and physicians for chest pain

Patients who arrive at the emergency department with low-risk chest pain and talk through treatment options with a physician show improved knowledge of their health status and follow-up options, compared with patients who received standard counseling from a physician, according to Mayo Clinic research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Frequent TAVR to replace damaged aortic heart valve improves patient outcomes

The more frequently a hospital performs a minimally invasive technique called transcatheter aortic valve replacement, or TAVR, to replace a damaged aortic heart valve, the better patients fare, on average, immediately after the procedure, researchers reported at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Only a small fraction of people with very high cholesterol can attribute their condition to a genetic mutation related to familial hypercholesterolemia, but individuals with these mutations face a high risk of developing early-onset coronary artery disease, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Investigational drug abaloparatide-SC may help increase bone mineral density in postmenopausal women

The investigational drug abaloparatide-SC (subcutaneous) may help increase bone mineral density in postmenopausal women and reduce their risk of fracture, new industry-sponsored research suggests. The results of the subgroup analysis within the ACTIVE clinical trial will be presented Friday, April 1, at ENDO 2016, the annual meeting of the Endocrine Society in Boston.

4 Apr 2016

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

A safe, new, minimally invasive treatment, developed by interventional radiologists, led to sustained weight loss in severely obese people, according to research presented at the Society of Interventional Radiology's 2016 Annual Scientific Meeting. Researchers said the treatment--bariatric arterial embolization (BAE)--could offer individuals a viable, safe alternative to surgical weight-loss treatments.

4 Apr 2016

Heart disease patients who experience mental stress ischemia tend to have higher levels of troponin

Some people with heart disease experience a restriction of blood flow to the heart in response to psychological stress. Usually silent (not painful), the temporary restriction in blood flow, called ischemia, is an indicator of greater mortality risk.

4 Apr 2016

Understanding idiopathic pulmonary fibrosis: an interview with Michael Durheim, M.D.

IPF is a rare and fatal lung disease that causes permanent scarring of the lungs, leading to debilitating shortness of breath and cough in affected patients. It affects as many as 132,000 Americans, most commonly those over the age of 65.

4 Apr 2016

CHMP recommends conditional marketing authorisation for Janssen’s daratumumab

Janssen-Cilag announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended the granting of a conditional marketing authorisation for first-in-class CD38 immunotherapy daratumumab in the European Union.

4 Apr 2016

Leading entrepreneurs, innovators to take part in Royal Society of Medicine's 12th Medical Innovations Summit

A group of leading entrepreneurs and innovators will be gathering at the Royal Society of Medicine on Saturday 16 April to take part in the Society’s 12th Medical Innovations Summit. Providing a twice-yearly platform for the presentation and discussion of inspirational ideas and developments in the field of medicine and healthcare, the Summits encourage innovators at the very beginning of their careers, as well as established clinicians and academics.

4 Apr 2016

Study: Age and gender affects prevalence of certain peripheral vascular diseases

New findings from large-scale studies of more than 3.6 million people who underwent screening for cardiovascular disease reveals that a person's age and gender affects the prevalence of certain types of peripheral vascular diseases (PVD), and that diabetes is a major risk factor for developing these diseases, even in patients without heart disease.

2 Apr 2016

USC study finds coffee consumption decreases colorectal cancer risk

Whether you like your coffee black, decaf, half-caff or even instant, feel free to drink up. Researchers at the University of Southern California (USC) Norris Comprehensive Cancer Center of Keck Medicine of USC have found that coffee consumption decreases the risk of colorectal cancer.

2 Apr 2016

Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

In obesity, the body's immune system can treat tissues as if they are suffering from a low-grade chronic infection. This obesity-induced inflammation is an important contributor to insulin resistance, a condition that can progress into type 2 diabetes.

2 Apr 2016

NTU researchers make breakthrough to tackle growing concern of antibiotic resistance

Scientists at Nanyang Technological University, Singapore have discovered that antibiotics can continue to be effective if bacteria's cell-to-cell communication and ability to latch on to each other are disrupted.

2 Apr 2016

Researchers propose new method for diagnosis of bacterial infection in preterm infants

A research group led by Kobe University Professor MORIOKA Ichiro (Graduate School of Medicine, Department of Pediatrics), Associate Professor OSAWA Kayo (Graduate School of Health Sciences, Department of Biophysics), and Clinical Technologist SATO Itsuko (Kobe University Hospital, Department of Clinical Laboratory) is proposing a new criterion for diagnosis of bacterial infection in preterm infants.

2 Apr 2016

MicroRNA controls tumor cell proliferation in most aggressive large B-cell lymphoma

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine showed that a microRNA called miR-181a dampens signals from the cancer-driving NFκB protein pathway in the most aggressive large B-cell lymphomas (DLBCL). By reducing NFκB signaling, miR-181a controls tumor cell proliferation and survival and could be the target of novel therapies. The study was published in the journal Blood.

2 Apr 2016

Medicine News and Research

Study evaluates long-term outcomes of TAVR with SAPIEN 3 in intermediate-risk patients

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Society of Interventional Radiology honors outstanding achievers with annual awards

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Patient-oriented tool helps shared decision-making between patients and physicians for chest pain

Frequent TAVR to replace damaged aortic heart valve improves patient outcomes

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Investigational drug abaloparatide-SC may help increase bone mineral density in postmenopausal women

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

Heart disease patients who experience mental stress ischemia tend to have higher levels of troponin

Understanding idiopathic pulmonary fibrosis: an interview with Michael Durheim, M.D.

CHMP recommends conditional marketing authorisation for Janssen’s daratumumab

Leading entrepreneurs, innovators to take part in Royal Society of Medicine's 12th Medical Innovations Summit

Study: Age and gender affects prevalence of certain peripheral vascular diseases

USC study finds coffee consumption decreases colorectal cancer risk

Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

NTU researchers make breakthrough to tackle growing concern of antibiotic resistance

Researchers propose new method for diagnosis of bacterial infection in preterm infants

MicroRNA controls tumor cell proliferation in most aggressive large B-cell lymphoma

Everything there is to know about biosimilars eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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