CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

Study provides attainable goals for return to sports after reconstructive foot surgery

Many patients who undergo surgery to correct a collapsing foot share the question: Will I be able to get back to doing the things I love?

22 Mar 2022

20% of childhood AML cases associated with rare genetic changes inherited through family bloodlines

It's a diagnosis you never want to hear: Acute Myeloid Leukemia (AML). These three words represent a devastating diagnosis of childhood cancer with dire consequences for many families.

21 Mar 2022

Study explores prevalence and symptom trajectory of long COVID

A new study estimated long-term COVID-19, or, long COVID, and the trajectory of disease symptoms in a representative sample in the US.

21 Mar 2022

Pfizer CEO pushes yearly shots for covid. Not so fast, experts say.

When Pfizer CEO Albert Bourla said March 13 that all Americans would need a second booster shot, it struck many covid experts as a self-serving remark without scientific merit. It also set off spasms of doubt over the country's objectives in its fight against the coronavirus.

21 Mar 2022

Expert reveals why brain science should be embraced in Sub-Saharan Africa

Medical conditions that affect the brain and the nerves in the human body — called neurological disorders — contribute greatly to the global burden of diseases, but even more so in low- and middle-income countries.

19 Mar 2022

New insight into how gut bacteria work to counter intestinal inflammation

Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.

16 Mar 2022

Higher SARS-CoV-2 load in morning-collected samples

In a recent study posted to the medRxiv* preprint server, researchers identified that morning-collected nasal and saliva samples yielded better detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially in tests with low to moderate analytical sensitivity.

8 Mar 2022

Physicians' knowledge, attitudes, and preventative practices regarding the COVID-19 pandemic

Researchers conducted a global survey to assess the knowledge, attitudes, and practices of physicians towards COVID-19.

7 Mar 2022

NEJM editorial highlights the difficulty of diagnosing heart attacks in postoperative patients

Diagnosing heart attacks after heart surgery remains difficult due to shortcomings of current diagnostic tools when applied to postoperative patients, including the electrocardiogram and blood tests to detect levels of cardiac troponins, according to an editorial in the New England Journal of Medicine (NEJM) written by two UT Southwestern faculty members.

3 Mar 2022

Doing less exercise could deactivate a vital protein in the body, suggests study

Doing less exercise could deactivate a vital protein in the body, causing further inactivity and making exercise more difficult, new research suggests.

1 Mar 2022

Harvard researcher develops new model system to illuminate the fundamentals of aging

Huge amounts of time and money have been devoted to finding treatments for diseases that become more common as we age, like cancer and Alzheimer's.

28 Feb 2022

COVID-19 during pregnancy linked to maternal mortality or morbidity from obstetric complications

Pregnant and postpartum individuals infected with SARS-CoV-2 during pregnancy have an increased risk of maternal mortality or morbidity from obstetric complications, according to a recent study published in JAMA.

21 Feb 2022

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

Results from an international, randomized, double-blind, placebo-controlled, phase 3 clinical trial indicate that adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy prolongs the survival of men with metastatic, hormone-sensitive prostate cancer, a disease that is fatal in most cases.

18 Feb 2022

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

A new mutation was identified in 9 percent of relapsed cases of pediatric acute myeloid leukemia (AML) that may define a new subtype of the disease.

17 Feb 2022

Older adults can prevent memory decline by sticking to regular exercise

We all know exercise is good for us, but that still leaves plenty of questions. How much exercise? Who benefits the most? And when in our lives? New research led by University of Pittsburgh psychologists pools data from dozens of studies to answer these questions, showing that older adults may be able to prevent declines in a certain kind of memory by sticking to regular exercise.

17 Feb 2022

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Researchers identify and investigate the presence and evolution of the SARS-CoV-2 N and S glycoprotein proteins.

15 Feb 2022

Canadian study estimates incidence rate of reinfection in healthcare workers

Researchers from various Canadian institutions document all cases of reinfection discovered during the first year of the project.

15 Feb 2022

Treatment rates for major depressive disorder remain low worldwide, analysis reveals

A combined analysis of results from 149 earlier studies finds that treatment rates for major depressive disorder remain low worldwide, particularly for people living in low and lower-middle income countries.

15 Feb 2022

New review highlights vast array of theoretical models used to understand mental health problems

A new review of the theoretical models used around the world to assess, diagnose, research, and treat mental health problems has highlighted the vast array of approaches which exist.

11 Feb 2022

Antarctic soil sample from 2018 adds to the enigma of the COVID-19 pandemic

The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has long been debated among scientists. However, prior research found early genetic material of a unique SARS-CoV-2 variant from the soil on King George Island, Antarctica between 24 December 2018 and 13th January 2019.

9 Feb 2022

CLARITY News and Research

Further Reading

Study provides attainable goals for return to sports after reconstructive foot surgery

20% of childhood AML cases associated with rare genetic changes inherited through family bloodlines

Study explores prevalence and symptom trajectory of long COVID

Pfizer CEO pushes yearly shots for covid. Not so fast, experts say.

Expert reveals why brain science should be embraced in Sub-Saharan Africa

New insight into how gut bacteria work to counter intestinal inflammation

Higher SARS-CoV-2 load in morning-collected samples

Physicians' knowledge, attitudes, and preventative practices regarding the COVID-19 pandemic

NEJM editorial highlights the difficulty of diagnosing heart attacks in postoperative patients

Doing less exercise could deactivate a vital protein in the body, suggests study

Harvard researcher develops new model system to illuminate the fundamentals of aging

COVID-19 during pregnancy linked to maternal mortality or morbidity from obstetric complications

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

Older adults can prevent memory decline by sticking to regular exercise

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Canadian study estimates incidence rate of reinfection in healthcare workers

Treatment rates for major depressive disorder remain low worldwide, analysis reveals

New review highlights vast array of theoretical models used to understand mental health problems

Antarctic soil sample from 2018 adds to the enigma of the COVID-19 pandemic

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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New horizons in drug discovery: High-throughput & target-to-therapy advances

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Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology