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CRISPR/Cas9 gene editing technique could be controlled using RNA-based drugs

In just the past few years, researchers have found a way to use a naturally occurring bacterial system known as CRISPR/Cas9 to inactivate or correct specific genes in any organism. CRISPR/Cas9 gene editing activity runs continuously, though, leading to risk of additional editing at unwanted sites.

19 Jan 2016

Researchers suggest ways to make TB drugs more efficacious against mutations

Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure of the drugs interacting with an essential enzyme in the TB germ, also reveal why some TB drugs are more potent than others and suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant.

19 Jan 2016

Johns Hopkins study shows high doses of cocaine kill brain cells

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their own insides. Their results, moreover, bring with them a possible antidote, an experimental compound dubbed CGP3466B.

19 Jan 2016

Researchers identify protein structure linked to pain and heat perception

Touch a hot stove, and your fingers will recoil in pain because your skin carries tiny temperature sensors that detect heat and send a message to your brain saying, "Ouch! That's hot! Let go!"

19 Jan 2016

Combination of PARP inhibitors and c-MET may benefit breast cancer patients

Findings from a new study reveal that PARP inhibitors, an emerging class of drugs being studied in cancer clinical trials, may be enhanced by combining them with inhibitors targeting an oncogene known as c-MET which is overexpressed in many cancers.

19 Jan 2016

Omnicell's revolutionary medication automation cabinet system saves cost, increases efficiency

An 18-month trial in the trust which opened England’s first hospital dedicated to emergency care, Northumbria Specialist Emergency Care Hospital, has found that significant cost-savings and efficiencies can be made by installing a revolutionary medication automation cabinet system provided by Omnicell Ltd, a leading provider of medication adherence packaging and automated healthcare solutions.

19 Jan 2016

Innovative OPW program offers wellness services to improve work lives of HCMC providers

For many professions, finding the right balance between work schedules and home life can be challenging. Health care providers are not immune to this issue. In fact, stress and burnout are prevalent in the medical field and if left unaddressed, can affect both providers and patients.

19 Jan 2016

Concussions related to sports and recreation activities affect millions of Americans

Every year, between 3 million and 4 million Americans suffer concussions in sports and recreation. Head impacts and concussions caused by contact sports are a quickly growing epidemic among young athletes.

19 Jan 2016

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

We've all seen the headlines. "Man found to be shedding virulent strain of polio"; "Virulent flu strain in Europe hits the economy"; "Most virulent strain of E. coli ever seen contains DNA sequences from plague bacteria."

19 Jan 2016

Mount Sinai Heart starts TANSNIP-PESA study to determine how workplace-based lifestyle intervention reduces CV risk

World-renowned cardiologist Valentin Fuster, MD, PhD, Director of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, is undertaking a three-year study, known as the TANSNIP-PESA study, to determine whether a workplace-based lifestyle intervention, accompanied by imaging data, will lead to a reduction in the prevalence of cardiovascular (CV) disease risk factors related to lifestyle.

19 Jan 2016

New method helps generate cardiac cells for heart disease studies, drug discovery

For a team of Vanderbilt investigators trying to generate heart muscle cells from stem cells, a piece of broken equipment turned out to be a good thing.

18 Jan 2016

NSCLC treatments market in Europe expected to cross US$ 3 billion by 2019

According to recently published Pharmaion report, "Europe Non-Small Cell Lung Cancer Treatments Market Opportunities, 2010 - 2020", the non-small cell lung cancer (NSCLC) treatments market in Europe is anticipated to cross US$ 3 billion by 2019.

18 Jan 2016

USRDS report shows positive and negative trends in kidney disease in the U.S.

The annual data report from the United States Renal Data System reveals both positive and negative trends in kidney disease in the U.S.

18 Jan 2016

Scientists develop wireless brain sensors

A team of neurosurgeons and engineers has developed wireless brain sensors that monitor intracranial pressure and temperature and then are absorbed by the body, negating the need for surgery to remove the devices.

18 Jan 2016

Specialized oral nutrition supplement associated with 50% lower death rate in older patients

Results from a new clinical trial show that a specialized oral nutrition supplement was associated with a 50 percent lower death rate in older malnourished patients with a heart or lung disease 90 days following hospitalization.

18 Jan 2016

UM SOM selected to work with BARDA to develop radiologic and nuclear countermeasures

University of Maryland School of Medicine Department of Radiation Oncology Chair and Professor William F. Regine, MD, FACR, FACRO, and UM SOM Dean E. Albert Reece, MD, PhD, MBA, announced today that researchers at the UM SOM have been selected as key contractors by the Biomedical Advanced Research and Development Authority, for its Radiation Nuclear Animal Model Development program.

18 Jan 2016

Growing up in poverty could alter children's brain connectivity, increase risk of depression

Many negative consequences are linked to growing up poor, and researchers at Washington University St. Louis have identified one more: altered brain connectivity.

18 Jan 2016

TSRI researchers develop new technique for modifying complex drug molecules

Chemists at The Scripps Research Institute have developed a versatile new technique for making modifications—especially one type of extremely difficult, but much-sought-after modification—to complex drug molecules.

18 Jan 2016

New recommendations to reduce radiation-induced breast cancer risk from digital mammography

Radiation-induced breast cancer risk from digital mammography is low for the majority of women, but risk is higher in women with large breasts, who received 2.3 times more radiation and required more views per examination to image as much of the breast as possible compared to those with small or average-sized breasts.

18 Jan 2016

Health Canada approves immunotherapy clinical study to treat Epstein-Barr virus-related lymphomas

Health Canada recently approved, for the first time in Canada, a clinical project for a Phase I study aimed at treating lymphomas associated with the Epstein-Barr virus (EBV) through adoptive cellular immunotherapy that is specific to EBV.

18 Jan 2016

Medicine News and Research

CRISPR/Cas9 gene editing technique could be controlled using RNA-based drugs

Researchers suggest ways to make TB drugs more efficacious against mutations

Johns Hopkins study shows high doses of cocaine kill brain cells

Researchers identify protein structure linked to pain and heat perception

Combination of PARP inhibitors and c-MET may benefit breast cancer patients

Omnicell's revolutionary medication automation cabinet system saves cost, increases efficiency

Innovative OPW program offers wellness services to improve work lives of HCMC providers

Concussions related to sports and recreation activities affect millions of Americans

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

Mount Sinai Heart starts TANSNIP-PESA study to determine how workplace-based lifestyle intervention reduces CV risk

New method helps generate cardiac cells for heart disease studies, drug discovery

NSCLC treatments market in Europe expected to cross US$ 3 billion by 2019

USRDS report shows positive and negative trends in kidney disease in the U.S.

Scientists develop wireless brain sensors

Specialized oral nutrition supplement associated with 50% lower death rate in older patients

UM SOM selected to work with BARDA to develop radiologic and nuclear countermeasures

Growing up in poverty could alter children's brain connectivity, increase risk of depression

TSRI researchers develop new technique for modifying complex drug molecules

New recommendations to reduce radiation-induced breast cancer risk from digital mammography

Health Canada approves immunotherapy clinical study to treat Epstein-Barr virus-related lymphomas

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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