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Blood stem cell self-renewal dependent on surroundings

Stem cells have two important capabilities: they can develop into a wide range of cell types and simultaneously renew themselves, creating fresh stem cells. Using a model of the blood forming (hematopoietic) system, researchers at the Technical University of Munich (TUM) have now been able to precisely determine, which signaling pathways play an essential role in the self-renewal of blood stem cells. A particularly decisive role in this process is the interactive communication with surrounding tissue cells in the bone marrow.

3 Nov 2015

Approval to start trial of Videregen's replacement trachea technology

The INSPIRE consortium, led by Videregen Ltd, has received approval from the MHRA1 to start a UK clinical trial with its tissue engineered replacement trachea.

3 Nov 2015

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Alnylam Pharmaceuticals, Inc. has announced new results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR amyloidosis).

3 Nov 2015

Misleading symptoms confuse management of older patients with post-HSE relapse

Research shows that teenagers and adults with immune-mediated relapse after herpes simplex encephalitis rarely display the symptoms typically seen in children, delaying the initiation of vital immunotherapy.

3 Nov 2015

Standing one-quarter of the day linked to reduced likelihood of obesity

Standing for at least one-quarter of the day has been linked to lower odds of obesity in a new study led by the American Cancer Society in collaboration with The Cooper Institute, the University of Texas, and the University of Georgia.

3 Nov 2015

Researchers explore effects of hypoglycemia on cardiovascular autonomic control

Past studies have shown an association between strict control of blood sugar and increased mortality. These studies have also suggested that a consequence of this strict control is low blood sugar (called hypoglycemia), which may have adverse effects on the heart.

3 Nov 2015

Lab experiment leads researchers to major red blood cell discovery

A bizarre result of a routine lab experiment has led researchers at the University of Virginia School of Medicine to an unexpected new way to trigger the production of red blood cells. This could represent a significant step forward in the battle against anemia, benefitting people with diabetes, people with kidney disease or cancer, and older people for whom anemia can become a chronic problem.

3 Nov 2015

VUMC, UCSF investigators awarded $6 million NIH grant to develop implantable artificial kidney

The National Institutes of Health has awarded a four-year, $6 million grant to investigators at Vanderbilt University Medical Center and the University of California at San Francisco to develop an implantable artificial kidney.

3 Nov 2015

First scholarly medical journal launched by Marshall University School of Medicine

The Marshall University Joan C. Edwards School of Medicine has launched its first scholarly medical journal. The Marshall Journal of Medicine is a peer-reviewed, open-access online journal designed to shed light on medical issues and conditions of priority to West Virginians and the Appalachian region.

3 Nov 2015

Expert proposes new solution to current gridlock over regulation of dietary supplements

A former principal deputy commissioner of the U.S. Food and Drug Administration is proposing a solution to the current gridlock over the regulation of dietary supplements: Focus less on whether these vitamins, minerals and herbal extracts actually do what they claim and instead take important steps to improve their safety.

3 Nov 2015

Delay in hospital admittance increases risk of death for Ebola patients during epidemics

A retrospective study of Ebola epidemics in the Democratic Republic of Congo (DRC) suggested that each day of delay in hospital admittance was associated with an 11% increased risk of death for Ebola patients during epidemics.

3 Nov 2015

New peptide-based hydrogel could one day facilitate microsurgery

Skillful surgeons can do amazing things in extremely small places, but finding better ways to suture tiny blood vessels has been an ongoing challenge for even the best.

3 Nov 2015

Microbiome researcher Martin J. Blaser earns GUMC's Cura Personalis Award

Georgetown University Medical Center will bestow its highest honor, the Cura Personalis Award, upon Martin J. Blaser, MD, a world-renowned microbiome researcher and clinician.

3 Nov 2015

Pediatricians send away families who refuse to vaccinate their children

One in five pediatricians dismiss families who refuse to vaccinate their children, according to findings published today in the journal Pediatrics and based on research by faculty from the University of Colorado School of Medicine on the Anschutz Medical Campus.

3 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

Alexander Technique or acupuncture can relieve chronic neck pain

A large scale investigation by researchers at the University of York found that the use of Alexander Technique or acupuncture can significantly relieve chronic neck pain.

3 Nov 2015

WSU researcher to lead $2.5 million study on impact of Affordable Care Act in people with disabilities

A Washington State University researcher will lead a $2.5 million examination of the federal Affordable Care Act's impact on what may be the largest group in need of its services: people with disabilities.

3 Nov 2015

Healthy food can help low-income people better control their diabetes

To determine whether healthy food could help low-income people better control their diabetes, a pilot study by UC San Francisco and Feeding America tracked nearly 700 people at food banks in California, Texas and Ohio over two years.

3 Nov 2015

FHI 360, Accelovance collaborate to serve international drug development research efforts

Accelovance, Inc. (Accelovance), a global contract research organization (CRO) focusing in Oncology, Vaccines, and General Medicine and FHI 360, a global nonprofit organization with CRO capabilities focusing on clinical research in developing countries, have entered into a strategic alliance to more comprehensively serve the international drug development research efforts of pharmaceutical, governmental, and nonprofit organizations.

3 Nov 2015

CureVac raises €100M to enable rapid expansion of mRNA development platform, clinical-stage pipeline

CureVac, a clinical-stage biopharmaceutical company pioneering the field of mRNA-based technology, today announces that it has raised about $110 million (€100 million) to enable accelerated expansion of its industry-leading messenger RNA (mRNA) development platform and clinical-stage pipeline.

3 Nov 2015

Medicine News and Research

Blood stem cell self-renewal dependent on surroundings

Approval to start trial of Videregen's replacement trachea technology

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Misleading symptoms confuse management of older patients with post-HSE relapse

Standing one-quarter of the day linked to reduced likelihood of obesity

Researchers explore effects of hypoglycemia on cardiovascular autonomic control

Lab experiment leads researchers to major red blood cell discovery

VUMC, UCSF investigators awarded $6 million NIH grant to develop implantable artificial kidney

First scholarly medical journal launched by Marshall University School of Medicine

Expert proposes new solution to current gridlock over regulation of dietary supplements

Delay in hospital admittance increases risk of death for Ebola patients during epidemics

New peptide-based hydrogel could one day facilitate microsurgery

Microbiome researcher Martin J. Blaser earns GUMC's Cura Personalis Award

Pediatricians send away families who refuse to vaccinate their children

Patients with Down syndrome face additional challenge of early-onset dementia

Alexander Technique or acupuncture can relieve chronic neck pain

WSU researcher to lead $2.5 million study on impact of Affordable Care Act in people with disabilities

Healthy food can help low-income people better control their diabetes

FHI 360, Accelovance collaborate to serve international drug development research efforts

CureVac raises €100M to enable rapid expansion of mRNA development platform, clinical-stage pipeline

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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