Fentanyl News and Research

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Fentanyl is a powerful synthetic opiate analgesic similar to but more potent than morphine. It is typically used to treat patients with severe pain, or to manage pain after surgery. It is also sometimes used to treat people with chronic pain who are physically tolerant to opiates. It is a schedule II prescription drug.

Fentanyl-stimulant overdose deaths surge among older adults

Overdose deaths in adults age 65 and older from fentanyl mixed with stimulants, such as cocaine and methamphetamines, have surged 9,000% in the past eight years, matching rates found among younger adults, according to research presented at the ANESTHESIOLOGY 2025 annual meeting.

12 Oct 2025

GLP-1 therapeutics may have the potential to treat alcohol and drug addiction

A popular class of therapies for treating diabetes and obesity may also have the potential to treat alcohol and drug addiction, according to a new paper published in the Journal of the Endocrine Society.

9 Oct 2025

Medicaid unwinding linked to drop in opioid use disorder treatment

The end of pandemic-era enrollment enhancements for Medicaid was associated with a rise in the number of people ending medication treatment for opioid use disorder, as well as a decrease in the number of people beginning such treatment, according to a new RAND study.

29 Sep 2025

Study reveals unequal burden of the fentanyl epidemic across the United States

A new study illuminates how some areas of the country have been hit much harder than others by the fentanyl epidemic, which took more than 70,800 lives in 2022 alone.

17 Sep 2025

An HIV outbreak in Maine shows the risk of Trump’s crackdown on homelessness and drug use

Penobscot County, Maine, is grappling with the largest HIV outbreak in the state's history. Home to Bangor, a city of roughly 32,000, the county has identified 28 new cases over nearly two years.

16 Sep 2025

Limited uptake of over-the-counter naloxone despite initial surge in sales

Sales of the overdose reversal medication naloxone increased after it was made available to the public without a prescription but then dipped quickly in the period following debut of over-the-counter sales, according to a new RAND study.

16 Sep 2025

Buprenorphine treatment produces greatest health gains and cost savings for mothers and infants

Over the last 20 years, substance use-related deaths have more than doubled for women of reproductive age. Overdose deaths are now a leading cause of maternal mortality in the U.S., and in some states, the leading cause.

11 Sep 2025

Fentanyl abuse impairs cardiac cell function and contributes to heart rhythm defects

In recent years, fentanyl, a synthetic opioid that is 50 to 100 times stronger than morphine, has been a main contributor to the opioid crisis.

28 Aug 2025

New study supports personalized restart of methadone for opioid use disorder

A new study from University of Colorado Anschutz and Denver Health researchers, published today in JAMA Network Open, introduces a more individualized approach to restarting methadone treatment for people with opioid use disorder.

28 Aug 2025

Polysubstance-involved opioid overdoses found to be prevalent among youth

Most research suggests that opioid overdoses involving multiple substances in the United States typically occur among people ages 25-54.

26 Aug 2025

AI predicts designer drug structures for improved detection

How does one identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement. The chemical structure variations that help these compounds avoid detection also make them unpredictable in the body - a quality that poses serious health consequences.

21 Aug 2025

Optum Rx invokes open meetings law to fight Kentucky counties on opioid suits

UnitedHealth Group's multibillion-dollar pharmacy benefit manager, Optum Rx, is suing five Kentucky counties in an attempt to force them out of national opioid litigation against the company.

20 Aug 2025

Understanding opioid safety and overdose prevention for older adults

With increasing age, older adults are more likely to encounter health conditions and injuries that require opioid therapy for pain relief.

13 Aug 2025

New analgesic shows promise as opioid alternative

Opioids like morphine are widely used in medical practice due to their powerful pain-relieving effects. However, they carry the risk of serious adverse effects such as respiratory depression and drug dependence.

4 Aug 2025

Deadly opioid contaminants uncovered in Adelaide street drug supply

A synthetic opioid 1000 times more potent than morphine is infiltrating the street drug trade in Adelaide, Australia, sparking fears of a wave of overdoses that could be lethal.

1 Aug 2025

Exploring the changing intensity of opioid use

Illegal opioids can create substantial harms, but the extent of those harms depends on multiple factors, including the amount consumed.

16 Jul 2025

In a nation growing hostile toward drugs and homelessness, Los Angeles tries leniency

Inside a bright new building in the heart of Skid Row, homeless people hung out in a canopy-covered courtyard — some waiting to take a shower, do laundry, or get medication for addiction treatment.

8 Jul 2025

Most Medicaid plans cover naloxone but barriers still exist

A new study found that almost all plans in 40 states and Washington, DC covered at least one form of the opioid overdose reversal drug naloxone, although certain restrictions and quantity limits may still prevent people from accessing this life-saving drug.

27 Jun 2025

Synthetic opioids and designer benzodiazepines linked to driving impairment

No-one could claim to be unaware of the dangers of driving under the influence of drugs (DUID): drugs can increase the time needed to react, impair coordination, alertness, and cognition, and lower inhibitions, thus encouraging reckless and aggressive driving.

25 Jun 2025

Cardiovascular deaths surge among less educated Americans

About 525,000 more deaths occurred among US adults in 2023 than would be expected had pre-2010 mortality trends continued. More than 90 percent of these deaths occurred among individuals without a Bachelor's degree and were largely caused by cardiovascular diseases, underscoring how educational attainment can influence individuals' health opportunities and outcomes.

14 Jun 2025