Immune Response News and Research

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Specific immune suppression leads to severe COVID-19 disease

A new study published online on the preprint server medRxiv in May 2020 reports that specific changes in the way the human immune system responds to COVID-19 determine whether the individual develops moderate or severe illness.

2 Jun 2020

Reducing inflammation improves stroke recovery, may extend window for therapy

Reperfusion therapy, the gold standard for stroke treatment, helps restore blood flow after a stroke caused by a clot, preventing loss of brain tissue. However, only about 10% of stroke patients qualify, in part because of reperfusion therapy's narrow treatment window.

1 Jun 2020

NAU scientist collaborating on vault-based vaccine to prevent and treat COVID-19

C. Todd French, assistant professor of biology and leader of Northern Arizona University's new COVID-19 Testing Service Center, is working with scientists at Vault Pharma, an emerging biotechnology company, to test candidate vaccines against the novel coronavirus.

1 Jun 2020

Study uncovers how cancer cells protect themselves from viruses

Researchers at the Francis Crick Institute have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease.

1 Jun 2020

Study highlights potential benefits of new drug for inflammatory diseases

New research conducted by the University of Liverpool and AKL Research and Development Ltd, published in Inflammopharmacology, highlights the potential benefits of a new drug treatment on the human body's immune response in inflammation.

1 Jun 2020

COVID-19 mortality is significantly higher in hospitalized patients with diabetes

A new meta-analysis published on the preprint server medRxiv by the researchers from the United States and Greece reveals that the likelihood of death is 65% higher in hospitalized coronavirus disease (COVID-19) patients with diabetes when compared to non-diabetics – urging the adequate glucose control in the era of the pandemic.

31 May 2020

Study explores how parasites respond to climate change

Warming events are increasing in magnitude and severity, threatening many ecosystems worldwide. As the global temperatures continue to climb, it also raises uncertainties as to the relationship, prevalence, and spread of parasites and disease.

30 May 2020

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

A new type of immunotherapy treatment for metastatic non-small cell lung cancer (NSCLC) is being tested by Missak Haigentz, Jr., MD, medical director of hematology and oncology for Atlantic Health System.

30 May 2020

Scientists identify factors influencing outcomes in kidney cancer patients treated with immunotherapy

By analyzing tumors from patients treated with immunotherapy for advanced kidney cancer in three clinical trials, Dana-Farber Cancer Institute scientists have identified several features of the tumors that influence their response to immune checkpoint inhibitor drugs.

30 May 2020

Chimeron Bio and George Mason NCBID partner to develop a coronavirus vaccine

Chimeron Bio, an RNA therapeutics company, and George Mason University's National Center for Biodefense and Infectious Diseases, a leading institute conducting pioneering research on infectious diseases.

30 May 2020

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 May 2020

Researchers review all clinical and research findings related to COVID-19

Due to the devastating worldwide impact of COVID-19, the illness caused by the SARS-CoV-2 virus, there has been unprecedented efforts by clinicians and researchers from around the world to quickly develop safe and effective treatments and vaccines.

29 May 2020

Researchers investigate possible causes of high COVID-19 mortality in Italy

On March 11th, 2020 the World Health Organization declared Coronavirus disease (COVID-19) a pandemic.

29 May 2020

Rare deadly disease linked to coronavirus infection seen in children

Now, new evidence has shown that children with coronavirus disease (COVID-19) experience a Kawasaki-like illness, called multisystem inflammatory syndrome in children (MIS-C). The complication is akin to toxic shock syndrome, a condition that occurs due to sepsis. Though rare, the condition is life-threatening.

29 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020

A closer look at TMPRSS2: This could help treat COVID-19

The transmembrane protease serine-type 2 (TMPRSS2) protein plays a key role in COVID-19 infection since it primes the viral spike protein to allow viral entry into the target cell. A new study by researchers at Imperial College London and published on the preprint server bioRxiv in May 2020 describes the protein, which could be an attractive drug target to help manage COVID-19.

28 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020