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Experimental gene therapy may prevent neuronal degeneration in patients with Alzheimer's disease

Degenerating neurons in patients with Alzheimer's disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researchers at University of California, San Diego School of Medicine in the current issue of JAMA Neurology.

28 Aug 2015

UiO researchers test new nasal spray device for treating mental illness

Researchers at the University of Oslo have tested a new device for delivering hormone treatments for mental illness through the nose. This method was found to deliver medicine to the brain with few side effects.

27 Aug 2015

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.

27 Aug 2015

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

Health providers trained to perform malaria rapid diagnostic tests (RDT) are still prescribing valuable malaria medicines to patients who do not have malaria, according to new research published in PLOS ONE.

27 Aug 2015

New test predicts breast cancer relapse months in advance

UK-based researchers have developed a blood test that can predict whether patients with breast cancer will experience a relapse after receiving treatment, months before tumors are visible using hospital scans.

27 Aug 2015

University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

The University of Nottingham is to lead a £6.5m research project which aims to make the leap from 2D to 3D in the development of advanced materials and realise the true potential of regenerative medicine and medical devices for the future.

27 Aug 2015

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

Liver transplantation is currently the only established treatment for patients with end stage liver failure. However, this treatment is limited by the shortage of donors and the conditional integrity and suitability of the available organs. Transplanting donor hepatocytes (liver cells) into the liver as an alternative to liver transplantation also has drawbacks as the rate of survival of primary hepatocytes is limited and often severe complications can result from the transplantation procedure.

27 Aug 2015

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

About 3% of colorectal cancers are due to Lynch syndrome, an inherited cancer susceptibility syndrome that predisposes individuals to various cancers. Close blood relatives of patients with Lynch syndrome have a 50% chance of inheritance. The role that PMS2 genetic mutations play in Lynch syndrome has been underestimated in part due to technological limitations.

27 Aug 2015

Researchers design online database to help researchers identify cancer gene mutations

Many clinical trials use genome sequencing to learn which gene mutations are present in a patient's tumor cells. The question is important because targeting the right mutations with the right drugs can stop cancer in its tracks. But it can be difficult to determine whether there is evidence in the medical literature that particular mutations might drive cancer growth and could be targeted by therapy, and which mutations are of no consequence.

27 Aug 2015

Common gene mutation may cause brain damage associated with ALS and FTD

Johns Hopkins researchers say they have discovered some of the first steps in how a very common gene mutation causes the brain damage associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

27 Aug 2015

Single dose of oral cholera vaccine could save more lives in crisis situations

An oral cholera vaccine that is in short supply could treat more people and save more lives in crisis situations, if one dose were dispensed instead of the recommended two, new Johns Hopkins Bloomberg School of Public Health research suggests.

27 Aug 2015

Yale study identifies new barrier to caring for chronic hepatitis C patients

Nearly one in four patients with chronic hepatitis C (HCV) are denied initial approval for a drug therapy that treats the most common strain of the infection, according to a Yale School of Medicine study.

27 Aug 2015

Use of observation stays may lead to financial burden for some Medicare patients

In the midst of a growing trend for Medicare patients to receive observation care in the hospital to determine if they should be formally admitted, a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania shows that for more than a quarter of beneficiaries with multiple observation stays, the cumulative out-of-pocket costs of these visits exceeds the deductible they would have owed for an inpatient hospital admission.

27 Aug 2015

Cornell study reveals how obesity changes consistency of breast tissue

Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.

27 Aug 2015

Women's Medicine Collaborative primary care team earns NCQA recognition

The Women's Medicine Collaborative primary care team has been designated a Level 3 Patient-Centered Medical Home (PCMH) by the National Committee for Quality Assurance. The patient-centered medical home model of care emphasizes using coordination and communication to transform primary care to accommodate patients' needs. Having a nurse care manager work one on one with high-risk patients who have chronic conditions leads to a higher quality, better patient experience and reduced costs. Level 3 is NCQA's highest designation in its recognition program.

27 Aug 2015

Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana-Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine.

27 Aug 2015

Individuals having high blood levels of two closely related proteins experience few adverse health events

Individuals previously diagnosed with heart disease may be less likely to experience heart failure, heart attacks, or stroke, or to die from these events, if they have higher blood levels of two very closely related proteins, according to a new study led by a UC San Francisco research team.

27 Aug 2015

Physical inactivity poses important clinical, public health and fiscal challenges for the U.S.

What do a prominent physiologist and two-time survivor of pancreatic cancer and a world-renowned researcher whose landmark discoveries on aspirin, drug therapies of proven benefit and therapeutic lifestyle changes that have saved more than 1.1 million lives have in common? They are both passionate about the importance of regular physical activity in reducing risks of dying from heart attacks and strokes, as well as developing diabetes, hypertension and colon cancer. And more importantly, enhancing mental health and fostering healthy muscles, bones and joints in all Americans from childhood to the elderly.

27 Aug 2015

New Pitt analysis reveals causes of stillbirth among obese women

Obese women are nearly twice as likely as their lean counterparts to have stillborn babies for several specific, potentially preventable medical reasons, a new University of Pittsburgh Graduate School of Public Health analysis reveals.

27 Aug 2015

Researchers find that 26% of senior oncology patients use complementary or alternative medicines

Alternative medicines are widely thought to be at least harmless and very often helpful for a wide range of discomforts and illnesses. However, although they're marketed as "natural," they often contain active ingredients that can react chemically and biologically with other therapies.

27 Aug 2015

Medicine News and Research

Experimental gene therapy may prevent neuronal degeneration in patients with Alzheimer's disease

UiO researchers test new nasal spray device for treating mental illness

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

New test predicts breast cancer relapse months in advance

University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

Transplanting multi-layered sheet of liver cells into damaged liver improves function in test animals

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

Researchers design online database to help researchers identify cancer gene mutations

Common gene mutation may cause brain damage associated with ALS and FTD

Single dose of oral cholera vaccine could save more lives in crisis situations

Yale study identifies new barrier to caring for chronic hepatitis C patients

Use of observation stays may lead to financial burden for some Medicare patients

Cornell study reveals how obesity changes consistency of breast tissue

Women's Medicine Collaborative primary care team earns NCQA recognition

Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

Individuals having high blood levels of two closely related proteins experience few adverse health events

Physical inactivity poses important clinical, public health and fiscal challenges for the U.S.

New Pitt analysis reveals causes of stillbirth among obese women

Researchers find that 26% of senior oncology patients use complementary or alternative medicines

Everything there is to know about biosimilars eBook

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

Improving healthcare sustainability through carbon data

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