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Common diabetes drug metformin works in gut, not the bloodstream

Although metformin was introduced as a treatment for type 2 diabetes nearly 60 years ago and is now the recommended first-line treatment for newly diagnosed patients, researchers still debate precisely how the drug works.

19 Aug 2015

Pitt unveils research-based guidance to improve compliance while treating sepsis

As hospitals nationwide brace for rigorous mandates for care of septic patients that will be adopted by the Centers for Medicare & Medicaid Services in October, a University of Pittsburgh School of Medicine review unveils research-based guidance to improve compliance when treating this common and deadly syndrome.

19 Aug 2015

LINE-1 jumping gene unusually active in gastrointestinal cancer

Results of a trio of studies done on human cancer tissue biopsies have added to growing evidence that a so-called jumping gene called LINE-1 is active during the development of many gastrointestinal cancers.

19 Aug 2015

Save a child with asthma with a disposable paper cup

A disposable cup – favoured by many of the high street’s well known coffee shops – is the inspiration behind a new and scientifically reviewed device for the safe and prompt treatment of school age children suffering acute asthma, which often presents as an emergency situation.

19 Aug 2015

Mesenchymal stem cell exosomes offer hope in healing chronic wounds

Dr. Badiavas’ research demonstrates how mesenchymal stem cell (MSC) exosomes, cell-derived vesicles that exist in biological fluids, function to repair non-healing wounds.

19 Aug 2015

E-cigarettes may trigger smoking in high school students, study reveals

Among high school students in Los Angeles, those who had ever used electronic cigarettes were more likely to report initiation of smokable ("combustible") tobacco (such as cigarettes, cigars, and hookah) use over the next year compared with nonusers, according to a study in the August 18 issue of JAMA.

19 Aug 2015

Researchers refine breast cancer risk model to give more accurate assessment

A national risk model that gauges a woman's chance of developing breast cancer has been refined to give a more accurate assessment. The revised figures, based on data from more than one million patients, reveal a 300 percent increase in a subset of women whose five-year risk is estimated at 3 percent or higher.

19 Aug 2015

Women's contraceptive choices often driven by relationships, sexual activity

Women's contraceptive choices are more often driven by current relationships and sexual activity than by long-term pregnancy intentions, according to Penn State College of Medicine researchers.

19 Aug 2015

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

19 Aug 2015

Rowan study reveals how exposure to Hurricane Sandy impacts mental health among older adults

Researchers from the Rowan University School of Osteopathic Medicine presented findings at the "2015 Hurricane Sandy Conference: Translating Research into Practice," showing that strong neighborhood relationships reduced the incidence of symptoms of post-traumatic stress disorder (PTSD) among older adults exposed to Hurricane Sandy, the superstorm that devastated the Northeast United States.

19 Aug 2015

NIH funds multicenter study to evaluate impact of medical treatment in transgender youth

The National Institutes of Health has awarded $5.7M for a five-year, multicenter study, which will be the first in the U.S. to evaluate the long-term outcomes of medical treatment for transgender youth.

19 Aug 2015

Only 1 in 10 heart failure patients referred to cardiac rehabilitation program after hospitalization

Only 1 in 10 heart failure patients is referred to a cardiac rehabilitation program after being hospitalized, despite strong evidence that such exercise programs improve quality of life and reduce the likelihood of future hospitalizations.

19 Aug 2015

Johns Hopkins experts say hospital consolidation may reduce patient choice, increase medical expenses

In a commentary published in the Aug. 13 issue of JAMA, Johns Hopkins experts say consolidation of hospitals into massive chains threatens healthy competition, reduces patient choice and could drive up medical expenses.

19 Aug 2015

Scientists identify new pathway that may protect brain from Alzheimer's disease

It is a hallmark of Alzheimer's disease: Toxic protein fragments known as amyloid-β clumped together between neurons in a person's brain.

19 Aug 2015

E-cigarettes becoming more widely available in developing countries

Most of the debate around e-cigarettes has focused on the developed world, but the devices are becoming more widely available in some low- and middle-income countries, where there is even greater potential for impact on public health, say two Stanford University School of Medicine researchers.

19 Aug 2015

Survey identifies key factors linked to pediatric safety events in out-of-hospital emergent care situations

A national survey of more than 750 emergency medical services providers conducted by researchers at Oregon Health & Science University identified airway management skills, personal anxiety and limited pediatric care proficiency among key factors that may contribute to pediatric safety events for children in out-of-hospital emergent care situations.

19 Aug 2015

Loyola implants new percutaneous aortic heart valve that does not require open surgery

Loyola University Medical Center is the first center in Illinois to implant a new percutaneous aortic heart valve that does not require open heart surgery.

19 Aug 2015

Hot chilli may be the key to lose weight, say Adelaide University researchers

University of Adelaide researchers have discovered a high-fat diet may impair important receptors located in the stomach that signal fullness.

19 Aug 2015

NIH grants Clinical and Translational Science Award to UC San Diego

The Clinical and Translational Research Institute (CTRI) at University of California, San Diego has received a five-year Clinical and Translational Science Award (CTSA) for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health.

19 Aug 2015

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Intarcia Therapeutics, Inc. today announced positive top-line results from its 52-week Phase 3 FREEDOM-2 clinical trial to determine the comparative efficacy of the company's late-stage investigational candidate ITCA 650 to Merck's Januvia in reducing HbA1c in patients with type 2 diabetes following a year of treatment.

18 Aug 2015

Medicine News and Research

Common diabetes drug metformin works in gut, not the bloodstream

Pitt unveils research-based guidance to improve compliance while treating sepsis

LINE-1 jumping gene unusually active in gastrointestinal cancer

Save a child with asthma with a disposable paper cup

Mesenchymal stem cell exosomes offer hope in healing chronic wounds

E-cigarettes may trigger smoking in high school students, study reveals

Researchers refine breast cancer risk model to give more accurate assessment

Women's contraceptive choices often driven by relationships, sexual activity

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

Rowan study reveals how exposure to Hurricane Sandy impacts mental health among older adults

NIH funds multicenter study to evaluate impact of medical treatment in transgender youth

Only 1 in 10 heart failure patients referred to cardiac rehabilitation program after hospitalization

Johns Hopkins experts say hospital consolidation may reduce patient choice, increase medical expenses

Scientists identify new pathway that may protect brain from Alzheimer's disease

E-cigarettes becoming more widely available in developing countries

Survey identifies key factors linked to pediatric safety events in out-of-hospital emergent care situations

Loyola implants new percutaneous aortic heart valve that does not require open surgery

Hot chilli may be the key to lose weight, say Adelaide University researchers

NIH grants Clinical and Translational Science Award to UC San Diego

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Everything there is to know about biosimilars eBook

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

Improving healthcare sustainability through carbon data

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