Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

High vitamin D level improves survival rate in heart failure patients: Study

Survival rates in heart failure patients with reduced levels of vitamin D are lower than in patients with normal levels. This is the finding of a major study carried out at University Medical Center, Groningen, Netherlands. Results also suggest that low levels of vitamin D are associated with activation of the Renin Angiotensin System (RAS - a pivotal regulatory system in heart failure) and an altered cytokine profile.

2 Sep 2010

High levels of OPG hormone associated with adverse outcome after myocardial infarction

Patients suffering with heart failure are more likely to die if they have high levels of a bone hormone called osteoprotegerin (OPG).

2 Sep 2010

Incidence of acute myocardial infarction increases among young Italian women: Study

The incidence of acute myocardial infarction in Italy sharply increased, particularly among young women, between the years 2001 and 2005, according to a comprehensive study funded by the Human Health Foundation, a nonprofit Italian charity for biomedical research and health education in Spoleto, Italy. The results were published in Aging Clinical Experimental Research.

31 Aug 2010

ESC issues revised practice guidelines for management of AF

The European Society of Cardiology today issued revised practice guidelines for the management of atrial fibrillation, including guidance on the role of a novel oral treatment, dabigatran etexilate, for the prevention of stroke and systemic embolism in patients with atrial fibrillation.

31 Aug 2010

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

DANPACE, a Danish multicentre randomised trial comparing single lead atrial and dual chamber pacing in patients with sick sinus syndrome, concludes that dual chamber pacing, which was associated with lower rates of atrial fibrillation and re-operation, "should be the preferred pacing mode".

31 Aug 2010

ANTIPAF trial reveals ARBs do not reduce number of AF episodes in paroxysmal AF patients

Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting about 7 million people in Europe. It is a progressive chronic disease in which episodes become more frequent and long-lasting over time. Conventional anti-arrhythmic therapy aims at halting progression and reducing symptoms, but the use of most anti-arrhythmic drugs is compromised by severe side effects, such as pro-arrhythmia or extra-cardiac organ toxicity.

31 Aug 2010

Bioheart's MyoCell adult stem cell therapy shows effective for heart failure patients: Study

Bioheart, Inc., The mission of the Cell Therapy Foundation is to improve public health through the support of effective adult stem cell research and education. The Foundation aims to promote basic and applied knowledge, processes and cell therapies.

31 Aug 2010

Study: IV ibuprofen decreases pain, morphine use in pre and post-operative orthopedic surgery patients

Cumberland Pharmaceuticals Inc. today announced the publication of new data supporting the safety and efficacy of Caldolor® (ibuprofen) Injection in pre and post-operative orthopedic surgery patients. The study, which was published in the August edition of the peer-reviewed journal Pain Medicine, concludes that IV ibuprofen significantly decreased pain and morphine use when compared with placebo.

31 Aug 2010

Disruption of structural component in heart muscle cells occurs before decline in heart function

The disruption of a structural component in heart muscle cells, which is associated with heart failure, appears to occur even before heart function starts to decline, according to a new study by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

31 Aug 2010

Cell Therapy Foundation analysis calls for funding in medical research

Some of the most promising medical research conducted to treat diseases of the brain, heart, and circulatory system is moving too slowly to help millions of patients, according to the Cell Therapy Foundation, which advocates the use of adult stem cells to dramatically impact and improve the condition of patients who suffer from a variety of conditions.

31 Aug 2010

Royal Philips Electronics launches new iE33 xMATRIX cardiac ultrasound system

Royal Philips Electronics today announced the enhanced iE33 xMATRIX cardiac ultrasound system featuring a new ergonomic solution for more efficient adult echocardiograms, the X5-1 transducer. With this enhanced technology, Philips continues its tradition of simplified, patient-focused healthcare solutions by providing a more complete imaging solution.

From Philips Healthcare 30 Aug 2010

Selective lowering of heart rate reduces risk of death and hospitalization: Study

The results of a major international study presented at the European Society of Cardiology Congress in Stockholm and published simultaneously in The Lancet show, for the first time, that selectively lowering heart rate with a novel medication, ivabradine, significantly reduces risk of death and hospitalization for patients with heart failure. This also resolves a longstanding debate about whether lowering heart rate itself can actually lower the risk of heart disease progression.

30 Aug 2010

RLY5016 potassium binder helps to regulate hyperkalemia in heart failure patients

Results from a recent phase 2b clinical trial may provide a new approach to managing excess potassium levels in patients with heart failure and heart failure with chronic kidney disease.

30 Aug 2010

SHIFT study finds Ivabradine reduces heart failure risk

Ivabradine, a selective If inhibitor already investigated for its effects in coronary artery disease and left ventricular dysfunction, significantly lowers the risk of heart failure, according to results of the SHIFT study (Systolic Heart failure treatment with the If inhibitor ivabradine Trial).

30 Aug 2010

Large clinical trial does not confirm benefits of erythropoieitin for first ST-elevation myocardial infarction

Results from the HEBE III study, a prospective, randomised, multicentre trial performed in seven centres in the Netherlands, suggest that the promising effects of erythropoieitin seen in previous smaller studies cannot be confirmed for the improvement of clinical outcome in patients with a first ST-elevation myocardial infarction.

30 Aug 2010

Study finds bone marrow stem cell therapy improves efficacy in chronic heart failure

Bone marrow stem cell therapy improves ventricular performance, quality of life and survival in patients with chronic heart failure, according to results from the STAR-heart study.

30 Aug 2010

FDA approves Novartis' Tekamlo for treatment of high blood pressure

The US Food and Drug Administration (FDA) approved Tekamlo™ (aliskiren and amlodipine) tablets, a single-pill for the treatment of high blood pressure combining the only approved direct renin inhibitor, Tekturna® (aliskiren), with the widely used calcium channel blocker amlodipine. Tekamlo is approved as initial therapy for patients who are likely to need multiple drugs to achieve their blood pressure goals, and as replacement therapy for patients whose blood pressure is not adequately controlled with either aliskiren or amlodipine alone.

27 Aug 2010

Disulfiram drug effective in treating cocaine addiction: Research

Doctors have used the drug disulfiram to help patients stay sober for several decades. It interferes with the body's ability to metabolize alcohol, giving a fierce hangover to someone who consumes even a small amount of alcohol.More recently, disulfiram was shown to be effective in treating cocaine addiction as well, even though alcohol and cocaine affect the nervous system in different ways.

27 Aug 2010

FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

In its review of the BLA, the FDA stated the T-DM1 trials did not meet the standard for accelerated approval because all available treatment choices approved for metastatic breast cancer, regardless of HER2 status, had not been exhausted in the study population.

27 Aug 2010

Bioheart reports promising result for congestive heart failure treatment with stem cell therapy

Bioheart, Inc., announces that the treatments and 3 month follow up with stem cell therapy on the first two congestive heart failure patients has been performed successfully at Hospital Angeles Tijuana through its Center of Excellence, Regenerative Medicine Institute of Tijuana, Mexico.

27 Aug 2010

Heart Failure News and Research

Further Reading

High vitamin D level improves survival rate in heart failure patients: Study

High levels of OPG hormone associated with adverse outcome after myocardial infarction

Incidence of acute myocardial infarction increases among young Italian women: Study

ESC issues revised practice guidelines for management of AF

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

ANTIPAF trial reveals ARBs do not reduce number of AF episodes in paroxysmal AF patients

Bioheart's MyoCell adult stem cell therapy shows effective for heart failure patients: Study

Study: IV ibuprofen decreases pain, morphine use in pre and post-operative orthopedic surgery patients

Disruption of structural component in heart muscle cells occurs before decline in heart function

Cell Therapy Foundation analysis calls for funding in medical research

Royal Philips Electronics launches new iE33 xMATRIX cardiac ultrasound system

Selective lowering of heart rate reduces risk of death and hospitalization: Study

RLY5016 potassium binder helps to regulate hyperkalemia in heart failure patients

SHIFT study finds Ivabradine reduces heart failure risk

Large clinical trial does not confirm benefits of erythropoieitin for first ST-elevation myocardial infarction

Study finds bone marrow stem cell therapy improves efficacy in chronic heart failure

FDA approves Novartis' Tekamlo for treatment of high blood pressure

Disulfiram drug effective in treating cocaine addiction: Research

FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

Bioheart reports promising result for congestive heart failure treatment with stem cell therapy

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