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Study findings could lead to new ways to tailor therapies for cancer

By studying the yeast used in beer- and bread-making, researchers at the University of Pittsburgh School of Medicine have uncovered the mechanism by which ancient proteins repair DNA damage and how their dysfunction could lead to the development of tumors.

28 Jul 2015

Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

The University of Colorado Cancer Center and Loxo Oncology, Inc., a biopharmaceutical company focused on the discovery, development and commercialization of targeted cancer therapies, today announced the publication of a research brief in the online edition of the journal Cancer Discovery, describing the first patient with a tropomyosin receptor kinase (TRK) fusion cancer enrolled in the Phase 1 dose escalation trial of LOXO-101, the only selective TRK inhibitor in clinical development.

28 Jul 2015

Lidocaine benefits breast cancer survivors who experience pain during intercourse

Scientists at Oregon Health & Science University report that breast cancer survivors who experience pain during sexual intercourse, a common side effect of breast cancer treatment, may achieve comfort when liquid lidocaine is applied strategically to prevent pain.

28 Jul 2015

Recipients of GSA poster awards announced at 20th International C. elegans Meeting

The Genetics Society of America and the C. elegans research community are pleased to announce the recipients of the GSA poster awards at the 20th International C. elegans Meeting, which took place at the University of California, Los Angeles, June 24-28, 2015.

28 Jul 2015

IU awarded $4.5 million NIH grant to create new federally designated diabetes research center

The National Institutes of Health has awarded the Indiana University School of Medicine a five-year, $4.5 million grant to create a new federally designated Indiana Diabetes Research Center, one of just 16 such centers in the country.

28 Jul 2015

Leishmania-fighting immune cells that linger after initial infections help ward off secondary attack

Immune cells that hang around after parasitic skin infection help ward off secondary attack, according to a study in The Journal of Experimental Medicine. These skin squatters may prove to be the key to successful anti-parasite vaccines.

28 Jul 2015

Innovative approach to treating AAT deficiency

Researchers have demonstrated the feasibility of delivering an RNA that encodes for the protein alpha-1-antitrypsin (AAT)--which is missing or nonfunctional in the genetic disorder AAT deficiency--into cells in the laboratory, enabling the cells to produce highly functional AAT.

28 Jul 2015

New study to explore mechanisms responsible for taste changes following RYGB, diet-induced obesity

Currently, one of the most effective surgical methods for treating obesity is the Roux-en-Y gastric bypass surgery, which limits the amount of food and drink that can be ingested at one time and the amount of calories and nutrients absorbed through the intestinal tract. An unintended side effect of RYGB is that it reduces the patient's taste for sweet and fatty foods—but there is no scientific explanation for why these taste changes occur.

28 Jul 2015

New technology enhances investigations of epigenomes

A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer, is reported on today in the research journal Nature Methods.

28 Jul 2015

Wayne State leads landmark study that examines clinical use of polymyxin B to treat superbugs

With the decline of the development of new antibiotics due to the complexity and expense of discovering them, there has been a rapid growth of antibiotic resistant pathogens that is one of the leading causes of death. With the help of a nearly $4.9 million, 5-year grant from the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, Wayne State University School of Medicine researchers are leading a landmark multi-center, international study that will provide essential information to clinicians for use of polymoxin B in critically ill patients where no other treatments will work.

28 Jul 2015

UC San Diego Health signs affiliation agreement with La Jolla Institute for Allergy and Immunology

UC San Diego Health, with the University of California, San Diego School of Medicine, has entered into a multi-year affiliation agreement with La Jolla Institute for Allergy and Immunology designed to deepen existing collaborative relationships, boost basic research of diseases of the immune system and more quickly introduce new clinical treatments and therapies.

28 Jul 2015

Brazilian cardiovascular researcher receives Georg Forster Research Award

The cardiovascular researcher Professor Robson Augusto Souza dos Santos of the Federal University of Minas Gerais in Belo Horizonte, Brazil, has been awarded the Georg Forster Research Award of the Alexander von Humboldt Foundation.

28 Jul 2015

New technique improves survival time for glioblastoma patients by 50%

The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.

28 Jul 2015

Yale researchers confirm NF1 gene as major player in development of skin cancer

A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies.

28 Jul 2015

Rowan receives $2.55 million HRSA grant to create New Jersey Geriatrics Workforce Enhancement Program

Rowan University School of Osteopathic Medicine has received a three-year, $2.55 million dollar grant from the Health Resources Services Administration to establish the New Jersey Geriatrics Workforce Enhancement Program (NJGWEP).

28 Jul 2015

Protein imbalances within cells can cause ovarian cancer

Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found. The discovery is a major breakthrough because, until now, genetic aberrations have been seen as the main cause of almost all cancer.

28 Jul 2015

Research findings may provide new approach to treating male infertility

A team of researchers from the National University of Singapore's (NUS) Yong Loo Lin School of Medicine has demonstrated for the first time that hydrogen sulphide (H2S), when applied exogenously, could protect testicular germ cells, which are male reproductive cells, against heat-induced injury, which is one of the major causes of male infertility.

28 Jul 2015

Landmark study to provide critical information for optimized use of polymyxin B in critically ill patients

28 Jul 2015

Scientists uncover how CD68 protein acts as gateway for malaria parasite to enter the liver

Scientists uncover a port of liver entry for malaria parasites in a report published in The Journal of Experimental Medicine. If these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.

28 Jul 2015

Inflammation plays role in onset of delirium in older adults

Delirium is an acute state of confusion that often affects older adults following surgery or serious illness. Now a study led by researchers at Beth Israel Deaconess Medical Center confirms that inflammation - an immune response that develops when the body attempts to protect itself from harmful stimuli -- plays a role in the onset of delirium.

28 Jul 2015

Medicine News and Research

Study findings could lead to new ways to tailor therapies for cancer

Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

Lidocaine benefits breast cancer survivors who experience pain during intercourse

Recipients of GSA poster awards announced at 20th International C. elegans Meeting

IU awarded $4.5 million NIH grant to create new federally designated diabetes research center

Leishmania-fighting immune cells that linger after initial infections help ward off secondary attack

Innovative approach to treating AAT deficiency

New study to explore mechanisms responsible for taste changes following RYGB, diet-induced obesity

New technology enhances investigations of epigenomes

Wayne State leads landmark study that examines clinical use of polymyxin B to treat superbugs

UC San Diego Health signs affiliation agreement with La Jolla Institute for Allergy and Immunology

Brazilian cardiovascular researcher receives Georg Forster Research Award

New technique improves survival time for glioblastoma patients by 50%

Yale researchers confirm NF1 gene as major player in development of skin cancer

Rowan receives $2.55 million HRSA grant to create New Jersey Geriatrics Workforce Enhancement Program

Protein imbalances within cells can cause ovarian cancer

Research findings may provide new approach to treating male infertility

Landmark study to provide critical information for optimized use of polymyxin B in critically ill patients

Scientists uncover how CD68 protein acts as gateway for malaria parasite to enter the liver

Inflammation plays role in onset of delirium in older adults

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

Improving healthcare sustainability through carbon data

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