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Scientists identify key protein behind drug-resistant leukemia

Acute lymphoblastic leukemia, or ALL, is the most common form of childhood cancer. While most children treated for this disease survive, in a subgroup of patients the disease does not respond to treatment.

19 May 2011

APP receives FDA approval to market Gemcitabine HCI for Injection, USP in 2 g dosage

APP Pharmaceuticals, Inc., a wholly owned subsidiary of Fresenius Kabi Pharmaceuticals Holding, Inc., announced today that it has received approval from the U.S. Food and Drug Administration to market Gemcitabine HCI for Injection, USP, in the 2 g dosage strength. APP will launch this presentation of Gemcitabine immediately.

19 May 2011

Two genes linked to worst cases of esophageal cancer

University of Rochester Medical Center researchers have pinpointed two genes that are amplified in the worst cases of esophageal cancer, providing data to support a new investigational treatment that targets those same genes.

19 May 2011

MDC researchers comprehensively quantify gene expression for the first time

How do genes control us? This fundamental question of life still remains elusive despite decades of research. Genes are blueprints for proteins, but it is the proteins that actually carry out vital functions in the body for maintaining life. Diseases such as cancer are not only characterized by altered genes, but also by disturbed protein production.

19 May 2011

Children exposed to maternal smoking in utero have increased DNA methylation in AXL gene

Children whose mothers or grandmothers smoked during pregnancy are at increased risk of asthma in childhood, but the underlying causes of this are not well understood. Now a new study indicates changes in a process called DNA methylation that occurs before birth may be a root cause.

19 May 2011

Pfizer's axitinib Phase 3 trial in advanced renal cell carcinoma meets primary endpoints

Pfizer Inc. today announced data from the pivotal Phase 3 AXIS 1032 trial, showing that in patients with previously treated advanced renal cell carcinoma, axitinib significantly extended progression-free survival at the 47th Annual American Society of Clinical Oncology meeting in Chicago from June 3-7, 2011.

19 May 2011

Berkeley Lab scientists contribute to remarkable advance in nuclear magnetic resonance

Nuclear magnetic resonance, a scientific technique associated with outsized, very low temperature, superconducting magnets, is one of the principal tools in the chemist's arsenal, used to study everything from alcohols to proteins to such frontiers as quantum computing.

19 May 2011

A new gene expression analysis technique on a single molecule sequencer

A new gene expression technique adapted for single molecule sequencing has enabled researchers at the RIKEN Omics Science Center (OSC) to accurately and quantitatively measure gene expression levels using only 100 nanograms of total RNA. The technique, which pairs RIKEN's Cap Analysis of Gene Expression (CAGE) protocol with the Helicos(R) Genetic Analysis System developed by Helicos BioSciences Corporation, opens the door to the detailed analysis of gene expression networks and rare cell populations. In recent years, next-generation DNA sequencers have produced an increasingly detailed picture of how genes are expressed at the molecular level. The transcriptional output of these genes - the RNA copies produced from DNA - has revealed a richness of complexity in transcript structure and function, providing insights into the molecular-level properties of cancers and other diseases.

19 May 2011

Common gene fault triggers a ripple of molecular signals leading to more aggressive cervical cancer

Cancer Research UK scientists have discovered that a common gene fault in cervical cancer cells triggers a ripple of molecular signals - which makes the disease more aggressive, according to research published in The Journal of Pathology.

19 May 2011

'Gatekeeper' protein plays a key role in skin-cancer prevention

New research from North Carolina State University shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice.

19 May 2011

Vitamin D plays a key role in protection against childhood asthma

Vitamin D, which is primarily absorbed from the sun, plays a role in protection against childhood asthma. Now, a new study led by Valencian researchers has shown that children who live in colder, wetter cities are at greater risk of suffering from this respiratory problem, since there are fewer hours of sunlight in such places.

19 May 2011

Biothera begins dosing in Imprime PGG and cetuximab combination Phase III trial for colorectal cancer

Biothera began dosing patients today in a Phase III trial evaluating Imprime PGG in combination with cetuximab as a potential new treatment for recurrent or progressive KRAS wild-type colorectal cancer.

19 May 2011

Face masks worn by TB patients could cut transmission rates to non-infected patients

Face masks worn by patients infected with tuberculosis (TB) may be able to significantly cut transmission rates to non-infected patients, according to a new study by researchers from the U.S. and South Africa. The study was conducted in a specialized airborne infections research facility in South Africa, which was designed to allow study of methods to control the spread of TB.

18 May 2011

Scientists nail mechanism causing embryonic stem cells to differentiate into specialised cells

A team led by developmental biologist Professor Christophe Marcelle has nailed the mechanism that causes stem cells in the embryo to differentiate into specialised cells that form the skeletal muscles of animals' bodies.

18 May 2011

New data on personalized approaches for skin, ovarian and lung cancer to be presented at ASCO meeting

Genentech, a member of the Roche Group, today announced that data showing new personalized approaches for people with skin and lung cancer, plus new data with Avastin in ovarian cancer, will be presented at the 47th Annual Meeting of the American Society of Clinical Oncology.

18 May 2011

Aeterna Zentaris first quarter revenues increase to $7.4 million

Aeterna Zentaris Inc., a late-stage drug development company specialized in oncology and endocrine therapy, today reported financial and operating results as at and for the first quarter ended March 31, 2011.

18 May 2011

New book provides insight into new stem cell therapies for stabilizing heart function

A new book edited by researchers at Worcester Polytechnic Institute and the Stony Brook University School of Medicine provides a comprehensive look at the science and application of cellular therapies aimed at the leading cause of death---heart disease.

18 May 2011

Study: 80% of U.S. physicians use Herceptin for HER2-positive metastatic gastric cancer treatment

In just over a month following the FDA's October 2010 approval of Roche's Herceptin for HER2-positive metastatic gastric cancer, more than 80 percent of U.S. physicians report using the drug, according to new research by GfK HealthCare.

18 May 2011

Workplace smoking ban improves respiratory health and reduces emergency admissions

Workplace smoking bans are gaining ground globally, and one study has shown that they may have significant health effects. The study, conducted by researchers in Dublin, found that emergency room admissions due to respiratory illness dropped significantly in Ireland after the implementation of a workplace smoking ban, compared to admissions that took place before the ban went into effect.

18 May 2011

Queen's University scientists partner to treat premature baby blindness with stem cells

Scientists from the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast are teaming up to develop a cure to an illness that can lead to blindness in premature babies, thanks to funding from children's charity Action Medical Research.

18 May 2011

Cell News and Research

Scientists identify key protein behind drug-resistant leukemia

APP receives FDA approval to market Gemcitabine HCI for Injection, USP in 2 g dosage

Two genes linked to worst cases of esophageal cancer

MDC researchers comprehensively quantify gene expression for the first time

Children exposed to maternal smoking in utero have increased DNA methylation in AXL gene

Pfizer's axitinib Phase 3 trial in advanced renal cell carcinoma meets primary endpoints

Berkeley Lab scientists contribute to remarkable advance in nuclear magnetic resonance

A new gene expression analysis technique on a single molecule sequencer

Common gene fault triggers a ripple of molecular signals leading to more aggressive cervical cancer

'Gatekeeper' protein plays a key role in skin-cancer prevention

Vitamin D plays a key role in protection against childhood asthma

Biothera begins dosing in Imprime PGG and cetuximab combination Phase III trial for colorectal cancer

Face masks worn by TB patients could cut transmission rates to non-infected patients

Scientists nail mechanism causing embryonic stem cells to differentiate into specialised cells

New data on personalized approaches for skin, ovarian and lung cancer to be presented at ASCO meeting

Aeterna Zentaris first quarter revenues increase to $7.4 million

New book provides insight into new stem cell therapies for stabilizing heart function

Study: 80% of U.S. physicians use Herceptin for HER2-positive metastatic gastric cancer treatment

Workplace smoking ban improves respiratory health and reduces emergency admissions

Queen's University scientists partner to treat premature baby blindness with stem cells

What are the challenges of cell line development? eBook

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