Immune Response News and Research

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Researchers identify antibodies that hold promise as Ebola treatments

The fight to contain the 2013-16 Ebola outbreak in West Africa was hampered by the lack of an effective treatment or vaccine. Researchers funded in part by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, have studied the blood of an Ebola survivor, searching for human antibodies that might effectively treat not only people infected with Ebola virus, but those infected with related viruses as well.

18 May 2017

Biochemical self-destruct trigger guards brain cells when fighting against West Nile virus

In a turnabout, a biochemical self-destruct trigger found in many other types of cells appears to guard the lives of brain cells during an infection with West Nile virus.

18 May 2017

Tumor mutation load in patient's biopsy varies by age and type of cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors.

18 May 2017

Researchers identify many dangerous strains of TB pathogens

Researchers from the Vavilov Institute of General Genetics of the Russian Academy of Sciences (VIGG) and the Moscow Institute of Physics and Technology have established a catalog of mutations in 319 virulence genes of mycobacteria that cause tuberculosis.

16 May 2017

Scientists unravel mystery of T cell signaling process vital to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained a mystery.

16 May 2017

Study reveals unique retinal scar in Ebola survivors

Researchers from the University of Liverpool have conducted a study of Ebola survivors to determine if the virus has any specific effects on the back on the eye using an ultra widefield retinal camera.

16 May 2017

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

Analysis of a patient's gut microbiome - the microbial population of the gastrointestinal tract - may be able to predict the likelihood of successful treatment for inflammatory bowel disease with biologic drugs that target immune system activity.

16 May 2017

IBM scientists identify new way to trigger the body's immune response to fight diseases

IBM announced its researchers have identified a new way to trigger the body's immune response by using polymer-coated graphene sheets. The research was recently published in Nature Communications.

16 May 2017

Research findings provide insight into mechanisms underlying differences in efficacy of anti-TNF drugs

Osaka University-led researchers identified differences in how three drugs bind to tumor necrosis factor, a key mediator of inflammatory disease. The team used sedimentation velocity analytical ultracentrifugation to investigate drug-target binding in a physiological environment and at clinically-relevant concentrations.

15 May 2017

Study findings could pave way for better drugs to fight against parasitic infections

Immune cells, called macrophages, may rely on a compound to signal an attack to beat back attacks from parasitic worms, according to an international team of researchers, including Zissis C. Chroneos, associate professor of pediatrics, and microbiology and immunology at Penn State College of Medicine.

12 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Discovery of key signals in the lungs and liver could pave way for immune disorder treatments

The discovery of key signals that help tissues repair after injury could pave the way for new treatments for asthma and organ scarring, a study suggests.

12 May 2017

Scientists reveal how immune cells activate to kill parasitic worms

An international team of researchers including Zissis C. Chroneos, associate professor of pediatrics, and microbiology and immunology at Penn State College of Medicine, reveals how immune cells called macrophages activate to kill parasitic worms.

11 May 2017

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy.

11 May 2017

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

Researchers at the University of Cincinnati have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.

10 May 2017

Serum Institute signs licensing agreement to commercialize St. Jude vaccine against RSV

St. Jude Children's Research Hospital and the Serum Institute of India have signed a licensing agreement to complete development and commercialization of a St. Jude vaccine against the respiratory syncytial virus (RSV), the virus that causes croup and lower respiratory infections. RSV kills about 160,000 people, primarily infants, worldwide each year.

10 May 2017

Researchers discover that microRNA can prevent excessive intestinal inflammation

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine.

9 May 2017

Novel approach cures diabetes in mice for one year without side effects

A potential cure for Type 1 diabetes looms on the horizon in San Antonio, and the novel approach would also allow Type 2 diabetics to stop insulin shots.

5 May 2017

Dendritic cells develop from specialized progenitors, research shows

Dendritic cells are gatekeepers of Immunity and are crucial for the detection and initiation of Immunity against pathogens and foreign substances. Up to now dendritic cell subtypes were thought to develop from one common progenitor.

5 May 2017

Children with bloodstream infections less likely to die than adults, study shows

Children with bloodstream infections caused by methicillin-resistant Staphylococcus aureus, a common antibiotic-resistant bacteria, are less likely to die than adults with this condition and have different risk factors for treatment failure, a new study led by a Children's National Health System clinician indicates.

5 May 2017

Immune Response News and Research

Researchers identify antibodies that hold promise as Ebola treatments

Biochemical self-destruct trigger guards brain cells when fighting against West Nile virus

Tumor mutation load in patient's biopsy varies by age and type of cancer

Researchers identify many dangerous strains of TB pathogens

Scientists unravel mystery of T cell signaling process vital to immune response

Study reveals unique retinal scar in Ebola survivors

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

IBM scientists identify new way to trigger the body's immune response to fight diseases

Research findings provide insight into mechanisms underlying differences in efficacy of anti-TNF drugs

Study findings could pave way for better drugs to fight against parasitic infections

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Discovery of key signals in the lungs and liver could pave way for immune disorder treatments

Scientists reveal how immune cells activate to kill parasitic worms

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

Serum Institute signs licensing agreement to commercialize St. Jude vaccine against RSV

Researchers discover that microRNA can prevent excessive intestinal inflammation

Novel approach cures diabetes in mice for one year without side effects

Dendritic cells develop from specialized progenitors, research shows

Children with bloodstream infections less likely to die than adults, study shows

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