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Study shows breast inflammation promotes development and progression of cancer

It took 12 years and a creation of a highly sophisticated transgenic mouse, but researchers at Kimmel Cancer Center at Jefferson have finally proven a long suspected theory: Inflammation in the breast is key to the development and progression of breast cancer.

15 Dec 2010

DBS targets same class of neuronal cells that respond to physical exercise and drug Prozac

Shooting steady pulses of electricity through slender electrodes into a brain area that controls complex behaviors has proven to be effective against several therapeutically stubborn neurological and neuropsychiatric disorders. Now, a new study has found that this technique, called deep brain stimulation (DBS), targets the same class of neuronal cells that are known to respond to physical exercise and drugs such as Prozac.

15 Dec 2010

UCSF scientists explain why oligodendroglioma is more responsive to therapy than other brain tumors

For patients with glioma, the most common primary brain tumor, new findings may explain why current therapies fail to eradicate the cancer. A UCSF-led team of scientists has identified for the first time that progenitor rather than neural stem cells underly a type of glioma called oligodendroglioma.

15 Dec 2010

cFLIP protein makes breast cancer cells resistant to TRAIL-induced apoptosis

Researchers at the Andalusian Institute for Molecular Biology and Regenerative Medicine and the University of Granada found that cFLIP -an inhibitor of death ligand-induced apoptosis- is not only essential in breast tumor cells resistance to TRAIL treatments (a death ligand with a potent therapeutic potential against cancer), but this protein is also key to the survival of such cancer cells.

14 Dec 2010

Study links large waistline to increased risk of heart problems and type 2 diabetes

Researchers at Eastern Virginia Medical School’s Strelitz Diabetes Center and the school’s department of physiological sciences have published research showing a strong link between a large waistline and increased risk of Type 2 diabetes and cardiovascular disease.

14 Dec 2010

ISTA commences bepotastine besilate nasal spray Phase 2 study in seasonal allergic rhinitis

ISTA Pharmaceuticals, Inc., today announced it has initiated a Phase 2 clinical study of bepotastine besilate nasal spray for the treatment of symptoms associated with seasonal allergic rhinitis, the inflammation of the nasal passages caused by allergies. The randomized, placebo-controlled, parallel-group environmental study will evaluate the safety and efficacy of bepotastine besilate, dosed twice daily, in patients presenting with allergic rhinitis caused by one of the most potent seasonal allergy triggers, Mountain Cedar pollen.

14 Dec 2010

Glycotope receives innovation award 2010 for GlycoExpress technology platform

Glycotope GmbH, a leading glycobiology company, has won the innovation award 2010 jointly presented by the German states of Berlin and Brandenburg in recognition of the company's GlycoExpress™ technology platform. GlycoExpress™ combines a very efficient improvement of the activities and side effects of a broad range of protein biopharmaceuticals with the suitability for a much broader patient population and a very high productivity.

14 Dec 2010

Tolerx commences TRX518 Phase 1 trial in malignant melanoma

Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, today announced that it has initiated a Phase 1 clinical trial to assess the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of TRX518, a monoclonal antibody designed to enhance the immune system by enabling T cells to more effectively attack cancer cells.

14 Dec 2010

Clinical trial investigates pomalidomide in only U.S. study for multiple myeloma

Multiple myeloma, a type of blood cancer in which malignant plasma cells are overproduced in the bone marrow, has led to an estimated 20,000 new diagnoses and 11,000 deaths in 2010. Patients with the disease, who have already failed previous treatments, may be considered for a currently enrolling Phase II study, examining a unique drug combination.

14 Dec 2010

Lexicon reports top-line results from LX2931 Phase 2a study in rheumatoid arthritis

Lexicon Pharmaceuticals, Inc., a biopharmaceutical company focused on discovering breakthrough treatments for human disease, announced top-line results from a recently completed Phase 2a study of LX2931 in patients with rheumatoid arthritis (RA). LX2931 is an orally-delivered, small molecule drug candidate that inhibits sphingosine-1-phosphate (S1P) lyase, an enzyme important for modulating the immune system by controlling S1P levels in lymphoid tissues.

14 Dec 2010

Response Genetics presents two gene expression analysis for personalized cancer tharapy selection

Response Genetics Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, announced the results of two separate analyses at national medical conferences.

14 Dec 2010

Lack of 'systematic reviews' in stroke research lead to waste of time, resources

Research being conducted into stroke needs to slow down and take stock if a therapeutic breakthrough is ever likely to happen, says a leading stroke expert.

14 Dec 2010

American Epilepsy Society recognizes neuroscientist for basic science advances

Douglas A. Coulter, Ph.D., a neuroscientist at The Children's Hospital of Philadelphia, received the 2010 Epilepsy Research Recognition Award for Basic Science from the American Epilepsy Society. The Society honored Dr. Coulter's pioneering contributions to epilepsy research on Monday, Dec. 6 at its Annual Meeting in San Antonio.

14 Dec 2010

Cannabis Science signs lease for new corporate headquarters in Denver, Colorado

Cannabis Science, Inc. a pioneering U.S. biotech company developing pharmaceutical cannabis products, is pleased to announce it has signed a lease for a new corporate headquarters as its new base of operations in Denver, Colorado. The 6,600 sq. ft. core facility at 2422 S. Trenton Way, Unit H will be dedicated to housing executive offices, administrative personnel, as well as the Lab Division core of operations for its cannabis formulations testing and FDA initiatives.

14 Dec 2010

Roche launches new xCELLigence System RTCA HT Instrument

The new xCELLigence System RTCA HT Instrument from Roche Diagnostics rounds out the company's portfolio in real-time cell analysis with a high-throughput product. The new instrument merges the power and flexibility of xCELLigence System technology with high-throughput analyses and workflows for automated screening applications.

From Roche Sequencing and Life Science 14 Dec 2010

EHSI negotiates potential option agreement with Regenetech for Rotary Cell Culture System

Emerging Healthcare Solutions, Inc. is negotiating a potential option agreement with biotech firm Regenetech, Inc.

14 Dec 2010

New theory explains spread of infectious diseases

New research using human-networking theory may give a clearer picture of just how, exactly, infectious diseases such as the common cold, influenza, whooping cough and SARS can spread through a closed group of people, and even through populations at large.

14 Dec 2010

Lack of strong molecular 'glue' allows tumour cells to break away and spread

A remarkable discovery into how tumour cells invade normal tissue should lead to vital diagnostic tools and help develop strategies to stop the spread of cancer cells. A new study by scientists at the Montreal Neurological Institute and Hospital of McGill University reveals that the surface of aggressive tumour cells lack the strong molecular 'glue' responsible for binding normal cells together.

14 Dec 2010

Immunomedics, UCB initiate enrollment in EMBODY 1 epratuzumab Phase III study in SLE

Immunomedics Inc. and UCB today announced the enrollment of the first patient into EMBODY™ 1, one of two pivotal Phase III studies of epratuzumab in patients with moderate to severe systemic lupus erythematosus (SLE). Patient enrollment for EMBODY™ 2 has also begun.

14 Dec 2010

Beta-catenin protein plays a key role in development of stem cells in acute leukaemia

Researchers at King's College London have discovered that leukaemic stem cells can be reversed to a pre-leukaemic stage by suppressing a protein called beta-catenin found in the blood.

14 Dec 2010

Cell News and Research

Study shows breast inflammation promotes development and progression of cancer

DBS targets same class of neuronal cells that respond to physical exercise and drug Prozac

UCSF scientists explain why oligodendroglioma is more responsive to therapy than other brain tumors

cFLIP protein makes breast cancer cells resistant to TRAIL-induced apoptosis

Study links large waistline to increased risk of heart problems and type 2 diabetes

ISTA commences bepotastine besilate nasal spray Phase 2 study in seasonal allergic rhinitis

Glycotope receives innovation award 2010 for GlycoExpress technology platform

Tolerx commences TRX518 Phase 1 trial in malignant melanoma

Clinical trial investigates pomalidomide in only U.S. study for multiple myeloma

Lexicon reports top-line results from LX2931 Phase 2a study in rheumatoid arthritis

Response Genetics presents two gene expression analysis for personalized cancer tharapy selection

Lack of 'systematic reviews' in stroke research lead to waste of time, resources

American Epilepsy Society recognizes neuroscientist for basic science advances

Cannabis Science signs lease for new corporate headquarters in Denver, Colorado

Roche launches new xCELLigence System RTCA HT Instrument

EHSI negotiates potential option agreement with Regenetech for Rotary Cell Culture System

New theory explains spread of infectious diseases

Lack of strong molecular 'glue' allows tumour cells to break away and spread

Immunomedics, UCB initiate enrollment in EMBODY 1 epratuzumab Phase III study in SLE

Beta-catenin protein plays a key role in development of stem cells in acute leukaemia

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