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Nanoscale cellular interactions unveiled by the SoTILT3D imaging platform

A team of researchers led by Anna-Karin Gustavsson at Rice University has developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale.

27 Nov 2024

Unmasking the secrets of bacterial DNA supercoiling

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic target.

26 Nov 2024

New discovery reveals dual binding in bitter taste receptors

"Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing" A new study revealed that some bitter molecules target their sensor through binding simultaneously at two distinct locations, one outside the cell, and the other inside it.

25 Nov 2024

CrestOptics and Tomocube partner to advance 3D imaging with new multimodal imaging platform

CrestOptics S.p.A., a manufacturer of high-end microscopy solutions and advanced systems for fluorescence microscopy, and Tomocube, a leader in holotomography (HT) technology, today announced a strategic collaboration to provide a next-generation multimodal imaging platform, the HT-X1™ Plus

From CrestOptics 25 Nov 2024

Deep learning revolutionizes RNA 3D structure prediction with RhoFold+

Researchers introduce RhoFold+, a groundbreaking deep learning model that predicts RNA 3D structures with unprecedented accuracy and efficiency, addressing critical challenges in structural biology.

24 Nov 2024

Researchers discover key protein interaction driving skin cancer growth

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.

22 Nov 2024

Advanced 3D brain models created to study memory and perception

The hippocampus is one of the most fascinating brain regions. Associated with the formation of memories, it also helps us to navigate through the world without getting lost.

22 Nov 2024

New microscopy technique enables 3D RNA analysis in intact mouse brains

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains.

22 Nov 2024

BiomedParse transforms biomedical image analysis with groundbreaking precision and scalability

BiomedParse, a revolutionary biomedical model, unifies image segmentation, detection, and recognition across nine modalities, outperforming traditional methods and enabling scalable, precise analysis of complex biomedical images.

21 Nov 2024

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option in combination with temozolomide.

21 Nov 2024

SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses

SARS-CoV-2 disrupts cholesterol metabolism by using its ORF3a protein to sequester cholesterol in lysosomes, reducing BMP levels and optimizing viral survival. This novel mechanism offers insights into long-term metabolic complications of COVID-19.

19 Nov 2024

Malaria crystal structure offers clues for more effective medications

Prof. Leslie Leiserowitz first became intrigued by malaria when he was a young boy in South Africa. His father, who scouted the continent in search of wood for the family business, brought back not only tales of elephants and gorillas but also skin rashes and ringing in his ears, side effects of the quinine he took to prevent malaria.

19 Nov 2024

TB pathogen's surprising growth mechanism challenges bacterial biology

The rod-shaped tuberculosis (TB) bacterium, which the World Health Organization has once again ranked as the top infectious disease killer globally, is the first single-celled organism ever observed to maintain a consistent growth rate throughout its life cycle.

15 Nov 2024

Artemisinin resistance detected in children with severe malaria in Uganda

Indiana University School of Medicine researchers, in collaboration with colleagues at Makerere University in Uganda, have uncovered evidence of partial resistance to artemisinin derivatives - the primary treatment for malaria - in young children with severe, or "complicated," malaria.

15 Nov 2024

Study reveals high-resolution structure of blood pressure-regulating receptor

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better drug targeting of the receptor for diseases like hypertension and heart failure.

15 Nov 2024