Acute Respiratory Distress Syndrome News and Research

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New research may shed light on people's susceptibility to COVID-19

Acute Respiratory Distress Syndrome in patients with COVID-19 can lead to death but more than 50% of these cases are associated with co-infection with bacterial pathogens.

23 Apr 2020

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

A new study published in April 2020 on the preprint server bioRxiv reports that the different levels of susceptibility of various organs to viral attack by the SARS-CoV-2 virus causing the huge pandemic of COVID-19 sweeping around the world can be predicted from the level of expression of two molecules, the ACE2 receptor, and the TMPRSS2 protein.

20 Apr 2020

COVID-19 lung injury is not like high altitude pulmonary edema

A group of researchers with experience in treating high altitude pulmonary edema have written to correct the misconception in medical social media forums and elsewhere that the lung injury seen in COVID-19 is not like typical acute respiratory distress syndrome and is instead like HAPE.

20 Apr 2020

Penn Medicine launches convalescent plasma therapy trial for COVID-19 patients

Convalescent plasma therapy for COVID-19 patients -- an experimental approach of giving a transfusion of plasma collected from a donor who has recovered from COVID-19 to a patient with an active infection -- is the focus of a new two-part research initiative at Penn Medicine.

20 Apr 2020

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

A team of scientists at the National Institute of Allergy and Infectious Diseases, which is part of the U.S. National Institutes of Health, has tested the efficacy of remdesivir, a nucleotide analog prodrug with a broad antiviral activity, as a COVID-19 treatment.

20 Apr 2020

How are the interventions against COVID-19 working in Sweden?

In a new study, Swedish researchers speculate the effects of the present intervention strategies on the healthcare system as the COVID-19 pandemic affects the nation. Their study titled, “Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity,” has not been published yet; however, the findings are available as pre-peer-reviewed study at medRxiv.

19 Apr 2020

Hydroxychloroquine and azithromycin treatment in 80 COVID-19 patients: short-term outcomes

The COVID-19 pandemic is still spreading around the world and affecting nearly 2.4 million people, with over 164,000 dead so far. With neither vaccine nor proven therapeutic drug being available so far, the need of the hour is for effective treatment. Now, a new study reports the potential usefulness of a combination of hydroxychloroquine and azithromycin as a treatment in mild cases of COVID-19 infection and urges the need for further evaluation and widespread use if its findings are confirmed.

19 Apr 2020

Gimsilumab trial starts in first US patient with ARDS and COVID-19

The first American patient with COVID-19 and acute respiratory distress syndrome (ARDS) has been put on the drug gimsilumab at Temple University Hospital, as part of the BREATHE clinical trial. The trial, sponsored by Roivant Sciences, will evaluate the effectiveness of intravenous gimsilumab in preventing death in patients with COVID-19 and ARDS.

16 Apr 2020

Are overactive immune cells causing COVID-19-related deaths?

While the COVID-19 pandemic is devastating many regions, the world over, a new paper published in the Journal of Experimental Medicine in April 2020 describes the possibility that the critical or very severe cases of COVID-19 are due to the production of neutrophil extracellular traps (NET) due to hyperactivated immune cells.

16 Apr 2020

Octapharma USA supports new COVID-19 clinical trial

Octapharma USA is supporting a new investigator initiated clinical trial led by George Sakoulas, M.D. of Sharp Memorial Hospital in San Diego, California focused on treating the most critical patients at the heart of the coronavirus pandemic, those experiencing respiratory failure who become ventilator dependent.

16 Apr 2020

Regular exercise may reduce risk of deadly complication in patients with COVID-19

Regular exercise may reduce the risk of acute respiratory distress syndrome, a major cause of death in patients with the COVID-19 virus, a top exercise researcher reports.

15 Apr 2020

Hypertensive patients on ACE inhibitors and angiotensin receptor blockers may have improved COVID-19 prognosis

Emerging concerns that common antihypertensive treatment approaches with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) – jointly known as renin-angiotensin-aldosterone system (RAAS) inhibitors – may exert a negative effect in COVID-19 patients are not grounded in scientific evidence, as reported by researchers in a recent review article published in Mayo Clinic Proceedings journal.

9 Apr 2020

What does recovery from COVID-19 look like? It depends. A pulmonologist explains.

Reports of recovery from serious illness caused by the coronavirus have been trickling in from around the world.

9 Apr 2020

Novel coronavirus targets specific secretory cells in the lungs

Viruses attack specific host cells, which can cause chaos in the body. The novel coronavirus, now called severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 for short, infects respiratory epithelial cells in the lining of the lung, causing difficulty of breathing. The usual cause of death of those who contract the virus is pneumonia and acute respiratory distress syndrome (ARDS). Now, a new study has found that SARS-CoV-2 specifically attack certain progenitor cells called bronchial transient secretory cells in the lungs.

9 Apr 2020

Ai used to detect COVID-19 pneumonia

Coronaviruses have 'spilled over' to human populations throughout history, causing respiratory illnesses, often associated with pneumonia. The severe acute respiratory syndrome (SARS), which emerged in 2002 in China, and the Middle East Respiratory Syndrome (MERS), which was first seen in Saudi Arabia in 2012, are similar to the current global pandemic spreading worldwide, the coronavirus disease (COVID-19).

9 Apr 2020

Trial assesses tissue plasminogen activator as a treatment for COVID-19-related respiratory failure

A new study published online in the Journal of Trauma and Acute Care Surgery in March 2020 reports that the anticoagulation drug tPA could be a potential aid in managing respiratory failure in patients with COVID-19.

8 Apr 2020

Cranfield University helps design simple, low-cost ventilators for critically-ill COVID-19 patients

A simple, low-cost Bag Valve Mask (BVM) ventilator to help critically-ill COVID-19 patients has been rapidly designed by experts at Cranfield University (UK) and built in Georgia Tech (USA) in a matter of days.

6 Apr 2020

ATS releases new guidance to help clinicians manage COVID-19 patients

An American Thoracic Society-led international task force has released a guidance document to help clinicians manage COVID-19 patients in the face of a worldwide pandemic and minimal empirical evidence to guide treatment.

6 Apr 2020

COVID-19 and renin-angiotensin system inhibitors

A new viewpoint article published in the journal JAMA Network in April 2020 deals with the use of a widely used category of cardiovascular medications in COVID-19 patients with hypertension, diabetes, and cardiovascular disease (CVD). These are the most common medical conditions that are found in COVID-19 patients and contribute disproportionately to mortality.

5 Apr 2020

IRB Barcelona and Amazon join forces to develop computational tool in the fight against COVID-19

There are currently more than 10,000 scientific articles related to coronavirus infections. In fact, in recent weeks, research to combat COVID-19 has accelerated, and more than 4,000 new academic papers have been published on potential vaccines, therapies, and treatments.

3 Apr 2020

Acute Respiratory Distress Syndrome News and Research

New research may shed light on people's susceptibility to COVID-19

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

COVID-19 lung injury is not like high altitude pulmonary edema

Penn Medicine launches convalescent plasma therapy trial for COVID-19 patients

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

How are the interventions against COVID-19 working in Sweden?

Hydroxychloroquine and azithromycin treatment in 80 COVID-19 patients: short-term outcomes

Gimsilumab trial starts in first US patient with ARDS and COVID-19

Are overactive immune cells causing COVID-19-related deaths?

Octapharma USA supports new COVID-19 clinical trial

Regular exercise may reduce risk of deadly complication in patients with COVID-19

Hypertensive patients on ACE inhibitors and angiotensin receptor blockers may have improved COVID-19 prognosis

What does recovery from COVID-19 look like? It depends. A pulmonologist explains.

Novel coronavirus targets specific secretory cells in the lungs

Ai used to detect COVID-19 pneumonia

Trial assesses tissue plasminogen activator as a treatment for COVID-19-related respiratory failure

Cranfield University helps design simple, low-cost ventilators for critically-ill COVID-19 patients

ATS releases new guidance to help clinicians manage COVID-19 patients

COVID-19 and renin-angiotensin system inhibitors

IRB Barcelona and Amazon join forces to develop computational tool in the fight against COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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