CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

Study explains why it is difficult to withdraw from certain antidepressants

Researchers at the University of Illinois Chicago are a step closer to discovering why it is so difficult for people to withdraw from some antidepressant medications.

28 May 2021

Study sheds new light on the memory function of sleep in humans

While we sleep, the brain produces particular activation patterns. When two of these patterns - slow oscillations and sleep spindles - gear into each other, previous experiences are reactivated.

25 May 2021

Virtual analysis identifies a potential natural inhibitor of SARS-CoV-2 Nsp15

A new paper reports the discovery of promising antiviral hit compounds through the use of computational modeling studies on natural compounds.

19 May 2021

AMP and APC urge congress to pass the VITAL Act

The Association for Molecular Pathology (AMP) and the Association of Pathology Chairs (APC) commend U.S. Senator Rand Paul (R-KY) for introducing legislation that would allow molecular pathology professionals to continue advancing and offering high-quality laboratory developed testing procedures (LDPs) for patient care.

19 May 2021

Doctors now must provide patients their health data, online and on demand

Last summer, Anna Ramsey suffered a flare-up of juvenile dermatomyositis, a rare autoimmune condition, posing a terrifying prospect for the Los Angeles resident: She might have to undergo chemotherapy, further compromising her immune system during a pandemic.

18 May 2021

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

In a paper published on the bioRxiv* preprint server, researchers report new monoclonal antibodies that target the S2 subunit and that have broad neutralization activity against several betacoronaviruses.

13 May 2021

High-powered MRI detects subtle differences in the hippocampus of people with Down syndrome

Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus--a region of the brain tied to memory and learning.

29 Apr 2021

New research sheds light on what causes sudden unexpected death in epilepsy

New research from the University of Virginia School of Medicine has shed light on the No. 1 cause of epilepsy deaths, suggesting a long-sought answer for why some patients die unexpectedly following an epileptic seizure.

28 Apr 2021

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

People who take a commonly-prescribed drug for inflammatory bowel disease (IBD) should not assume they are protected after a first dose of COVID-19 vaccine, after a large-scale study found many had poor antibody responses.

26 Apr 2021

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

The SARS-CoV-2 B.1.1.7 variant, also called the UK variant, was identified in London as well as in Southeast and East of England in December 2020. Since its emergence, the UK variant has undergone several mutations that have been said to have altered its infectivity and transmissibility in the community. The B.1.1.7 variant is defined by 17 mutations, several of which are located in the SARS-CoV-2 spike protein that mediates viral attachment and entry into human cells.

21 Apr 2021

Intestinal worm infection can cause severe sexually transmitted viral diseases

Infection with parasitic intestinal worms (helminths) can apparently cause sexually transmitted viral in-fections to be much more severe elsewhere in the body.

16 Apr 2021

FDA's new guidance provides clarity on remote interactive evaluation of drug facilities during COVID-19

During this worldwide public health emergency, the FDA has used a variety of tools to oversee facilities that manufacture FDA-regulated products.

15 Apr 2021

Researchers develop model for SARS-CoV-2 fusion intermediate that helps membrane fusion

The spike protein is the main part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the infection. It consists of two subunits S1 and S2. Upon entry of the virus into the human body, the S1 subunit helps the virus bind to the angiotensin-converting enzyme 2 (ACE2) receptors on host cells.

13 Apr 2021

New research could change how doctors treat some patients with high blood pressure

New research led by a professor at NUI Galway is set to change how doctors treat some patients with high blood pressure - a condition that affects more than one in four men and one in five women.

13 Apr 2021

Advanced computer model could lead to improvements in 'bionic eye' technology

There are millions of people who face the loss of their eyesight from degenerative eye diseases. The genetic disorder retinitis pigmentosa alone affects 1 in 4,000 people worldwide.

9 Apr 2021

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

A new study describes the use of a single dose of vaccine based on the viral protein called the receptor-binding domain (RBD) to elicit powerful neutralizing activity against both the Wuhan strain and the most concerning VOC called the South African (SA) strain.

7 Apr 2021

CLARITY News and Research

Further Reading

Study explains why it is difficult to withdraw from certain antidepressants

Study sheds new light on the memory function of sleep in humans

Virtual analysis identifies a potential natural inhibitor of SARS-CoV-2 Nsp15

AMP and APC urge congress to pass the VITAL Act

Doctors now must provide patients their health data, online and on demand

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

High-powered MRI detects subtle differences in the hippocampus of people with Down syndrome

New research sheds light on what causes sudden unexpected death in epilepsy

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

Intestinal worm infection can cause severe sexually transmitted viral diseases

FDA's new guidance provides clarity on remote interactive evaluation of drug facilities during COVID-19

Researchers develop model for SARS-CoV-2 fusion intermediate that helps membrane fusion

New research could change how doctors treat some patients with high blood pressure

Advanced computer model could lead to improvements in 'bionic eye' technology

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

Tissue architecture impacts the evolutionary course of cancer

Beckman Coulter life sciences brightens flow cytometry with new SuperNova polymer dyes portfolio

IQWiG releases revised version of its General Methods

COVID-19 long haulers report persistent neurological symptoms

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How Omics Technologies Are Transforming Biological Research and Drug Discovery

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Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology