Immune Response News and Research

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Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

A new drug that harnesses the immune system to attack tumors is highly effective against advanced bladder cancer, according to the results of an international clinical trial to be presented June 5 at the annual meeting of the American Society for Clinical Oncology.

6 Jun 2016

Experimental drug Rova-T shows safety, efficacy in treating advanced SCLC patients

The experimental "smart-bomb" drug rovalpituzumab tesirine (Rova-T) appears safe and shows efficacy in treating patients with advanced small cell lung cancer (SCLC), according to results from a first-in-human clinical trial to be presented today by a Memorial Sloan Kettering Cancer Center researcher at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago.

6 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

Scientists discover master dimmer switches that control activity of immune cells

A person's genetic makeup plays a role in autoimmune diseases such as multiple sclerosis that develop when the body is attacked by its own immune system. But little is known about how immune cells are pushed into overdrive.

3 Jun 2016

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high-risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody. The immunotherapy agent was produced on the St. Jude Children's Research Hospital campus where the study is still underway.

3 Jun 2016

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cancer immunotherapies--drugs that work by making a patient's immune system better at spotting and destroying tumor cells--are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinical trials with other diseases as well.

3 Jun 2016

Cigarette smoke promotes bacteria colonization, immune invasion

The mouth is one of the "dirtiest" parts of the body, home to millions of germs. But puffing cigarettes can increase the likelihood that certain bacteria like Porphyromonas gingivalis will not only set up camp but will build a fortified city in the mouth and fight against the immune system.

1 Jun 2016

New, inexpensive blood test helps detect low levels of mycobacteria that causes bTB

A new blood test to detect Mycobacteria in blood has been developed by a team at The University of Nottingham led by Dr Cath Rees, an expert in microbiology in the School of Biosciences and Dr Ben Swift from the School of Veterinary Medicine and Science.

1 Jun 2016

Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Oncologists at the Fred Hutchinson Cancer Research Center have successfully treated a patient with metastatic melanoma by combining two different types of immunotherapy. Cassian Yee and colleagues describe their approach in a paper, "Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient," that will be published online May 30 in The Journal of Experimental Medicine.

30 May 2016

Researchers demonstrate decisive role of cholesterol in T cell activation

T cell receptors are an important part of the human immune system. They are able to switch their conformation from an inactive to an active state spontaneously without any antigens present.

28 May 2016

Certain HLA genes may increase ovarian cancer risk in women

Researchers in the Center for Immunotherapy at Roswell Park Cancer Institute have evaluated the human leukocyte antigen (HLA), a group of genes that help regulate the body's immune system, for underlying differences in ovarian cancer patients' response to therapy.

28 May 2016

Researchers discover ANKRD55 gene linked to multiple sclerosis

The Ikerbasque researcher Koen Vandenbroeck, who heads the Neurogenomiks laboratory which reports to the Achucarro centre and the UPV/EHU-University of the Basque Country, together with other national and international groups, has shown that a genetic variant in the 5q11 chromosome, which is associated with susceptibility to developing multiple sclerosis, greatly regulates a gene known as ANKRD55. ANKRD55 is a gene with an unknown function.

28 May 2016

Malaria parasites use complement system to evade human immune response, study finds

The malaria parasite Plasmodium falciparum hijacks an immune system process to invade red blood cells, according to a study led by researchers at Penn State College of Medicine. Understanding how malaria invades the cells could lead to a more effective vaccine.

26 May 2016

SBP scientists discover new regulator of immune responses

Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a new regulator of immune responses. The study, published recently in Immunity, sheds new light on why T cells fail to clear chronic infections and eliminate tumors.

26 May 2016

Japanese scientists find evidence that cytokine IL-17A plays crucial role in psoriasis

Psoriasis is an inflammatory skin condition that affects some 125 million people worldwide. It is characterized by itchy, scaly skin plaques. The exact cause of psoriasis is unclear.

25 May 2016

Too much of sun exposure may cause hangover

Summer is preparing to make its debut in a few weeks, and along with it, most of us will flock to the outdoors to soak up sunshine and Vitamin D.

25 May 2016

National Cancer Moonshot initiative needs to target proteins that drive cancer

The National Cancer Moonshot initiative needs to move beyond genomics to target the proteins that are driving cancer, according to an Inova Health System and George Mason University collaborative paper published Thursday in the American Association for Cancer Research.

24 May 2016

Personalized DXM-loaded leukosomes may help treat inflammation

Nanosized Trojan horses created from a patient's own immune cells have successfully treated inflammation by overcoming the body's complex defense mechanisms, perhaps leading to broader applications for treating diseases characterized by inflammation, such as cancer and cardiovascular diseases.

24 May 2016

Heart failure patients who receive influenza vaccine less likely to develop dementia

Influenza vaccination is associated with a lower risk of dementia in patients with heart failure, according to a study in more than 20 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Ju-Chi Liu, director of the Division of Cardiovascular Medicine, Department of Medicine, Taipei Medical University - Shuang Ho Hospital, in New Taipei City, Taiwan.

24 May 2016

Flu jab linked to reduced hospitalisation risk in heart failure patients

The flu jab is associated with a reduced risk of hospitalisation in patients with heart failure, according to research presented today in a late breaking trial session at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure.

24 May 2016

Immune Response News and Research

Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

Experimental drug Rova-T shows safety, efficacy in treating advanced SCLC patients

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

Scientists discover master dimmer switches that control activity of immune cells

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cigarette smoke promotes bacteria colonization, immune invasion

New, inexpensive blood test helps detect low levels of mycobacteria that causes bTB

Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Researchers demonstrate decisive role of cholesterol in T cell activation

Certain HLA genes may increase ovarian cancer risk in women

Researchers discover ANKRD55 gene linked to multiple sclerosis

Malaria parasites use complement system to evade human immune response, study finds

SBP scientists discover new regulator of immune responses

Japanese scientists find evidence that cytokine IL-17A plays crucial role in psoriasis

Too much of sun exposure may cause hangover

National Cancer Moonshot initiative needs to target proteins that drive cancer

Personalized DXM-loaded leukosomes may help treat inflammation

Heart failure patients who receive influenza vaccine less likely to develop dementia

Flu jab linked to reduced hospitalisation risk in heart failure patients

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