Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

ATA guidelines provide recommendations for managing thyroid nodules and thyroid cancer in children

Previous guidelines from the American Thyroid Association for evaluating and managing thyroid nodules and thyroid cancers targeted adults. Recognizing the potential differences in clinical presentation and long-term outcomes, and the potential risks of overly aggressive therapy in pediatric patients with thyroid cancer, an ATA Task Force developed management guidelines for children with thyroid nodules and differentiated thyroid cancer (DTC), which are published in Thyroid, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers and the official journal of the American Thyroid Association.

23 Apr 2015

BMC pathologists develop protocols for processing, preserving forensic evidence

Boston Medical Center pathologists have developed a set of protocols for processing and preserving forensic evidence, such as shrapnel, bullets and other projectiles, in surgical specimens (i.e. amputated limbs, injured organs, etc.) after a terrorist attack based on lessons learned from the Boston Marathon bombing.

22 Apr 2015

University of Birmingham researchers identify new way to tackle chronic diseases

Researchers from the University of Birmingham have identified an important new way in which our immune systems are regulated, and hope that understanding it will help tackle the debilitating effects of type 1 diabetes, rheumatoid arthritis and other serious diseases.

22 Apr 2015

New mathematical model to predict pharmacodynamic activity may help improve drug discovery

A new mathematical model that uses drug-target kinetics to predict how drugs work in vivo may provide a foundation to improve drug discovery, which is frequently hampered by the inability to predict effective doses of drugs.

21 Apr 2015

New collaboration brings comprehensive genomic profiling to UC Davis

The UC Davis Comprehensive Cancer Center and the Department of Pathology and Laboratory Medicine have entered into a collaboration with Foundation Medicine, a leading molecular information company. The collaboration brings comprehensive genomic profiling into standard of care at UC Davis, allowing physicians to prescribe the most effective, targeted cancer treatments to patients based on the genomic information specific to each individual's cancer.

21 Apr 2015

Global changes in cancer cells' epigenome may determine disease progression

Genomic studies have illuminated the ways in which malfunctioning genes can drive cancer growth while stunting the therapeutic effects of chemotherapy and other treatments. But new findings from Weill Cornell Medical College investigators indicate that these genes are only partly to blame for why treatment that was at one point effective ultimately fails for about 40 percent of patients diagnosed with the most common form of non-Hodgkin Lymphoma.

21 Apr 2015

AACR throws spotlight on the experience of Individualized Molecular Pancreatic Cancer Therapy trial

After performing thousands of unsuccessful experiments in his attempt to perfect the light bulb, Thomas Edison famously remarked: "I have not failed, not once. I've discovered ten thousand ways that don't work."

21 Apr 2015

MGH researchers find probable mechanism associated with risk of developing serious diseases

Massachusetts General Hospital investigators have found the probable mechanism underlying a previously described biomarker associated with the risk of developing serious diseases ranging from cancer to cardiovascular disease and the risk of serious complications. In a paper published in the American Journal of Hematology, the research team reports finding that higher levels of a measure routinely taken as part of the complete blood count - the extent of variation in the size of red blood cells - is caused by reduced clearance of aging cells from the bloodstream.

20 Apr 2015

PCF announces Stupski Prize in Prostate Cancer Computational Oncology

The Prostate Cancer Foundation is pleased to announce the Stupski Prize in Prostate Cancer Computational Oncology, a first-in-field initiative designed to attract novel ideas to the rapidly changing field of large-scale cancer bioinformatics.

20 Apr 2015

Scientists reveal three major subsets of KRAS-mutant LUAC

Mutations of the KRAS gene are commonly known to lead to cancer. However, deeper understanding of exactly how they do this continues to be explored by cancer researchers.

20 Apr 2015

CAP pathologist shares four tips for women with breast cancer

For any woman, a diagnosis of breast cancer can be frightening. But as Rita Wilson's recent experience shows, engaging with the keystone of the diagnosis - the pathology report - can be critical in achieving good outcomes. Informed by rigorous scientific processes, training and team discussion, pathology reports identify a diagnosis, help indicate the right providers for a patient's care team and shape treatment plans.

20 Apr 2015

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

Almost one in four patients (24%) with advanced lung cancer in Europe, Asia and the US are not receiving EGFR test results before being started on treatment, researchers report at the European Lung Cancer Conference.

20 Apr 2015

May issue of Red Journal focuses on role of radiation therapy in current lymphoma treatment

The "Radiation and the Modern Management of Lymphoma" issue (May 1, 2015) of the International Journal of Radiation Oncology • Biology • Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology, is focused on the integral role of radiation therapy in current lymphoma treatment.

17 Apr 2015

Groundbreaking study looks at how puberty affects voice changes in male singers

The first round of tests have been completed for members of the Cincinnati Boychoir who are part of a joint study with Cincinnati Children's Hospital Medical Center to look at the changing voices of male singers.

17 Apr 2015

Inflammation plays causal role in neurologic changes associated with Lyme disease

About 15% of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and painful symptoms. New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, according to a study published in The American Journal of Pathology.

17 Apr 2015

Flagship Biosciences customizes assay development and tissue image analysis for advanced cell diagnostics RNAscope platform

Flagship Biosciences and Advanced Cell Diagnostics collaborate to develop quantitative RNAscope® assays for pharmaceutical clinical trials in the CLIA environment...

From Advanced Cell Diagnostics 16 Apr 2015

International science team pave way for fast and accurate diagnosis of the influenza virus

Statistics indicate that, on average, adults over the age of 30 only contract the influenza virus twice in a decade – but far more frequently (self) misdiagnose a cold virus (commonly rhinovirus or coronavirus) as being the flu...

16 Apr 2015

Leica Biosystems announces launch of Aperio VERSA scanner at AACR annual meeting

Leica Biosystems announces the introduction of the Aperio VERSA, a combination digital pathology research scanner for brightfield, fluorescence and FISH imaging at the American Association for Cancer Research annual meeting in Philadelphia, opening on April 18th, 2015.

16 Apr 2015

UAB research findings may lead to better treatment for women with HER2+ breast cancer

There are five subtypes of breast cancer, and they are distinct diseases with vastly different biologies that drastically alter their progression and responses to treatment. Understanding those differences is the starting point to a more effective, personalized treatment of breast cancer, which strikes more than 230,000 women in the U.S. each year.

16 Apr 2015

Oxycodone-related deaths drop 25% after implementation of Prescription Drug Monitoring Program

Oxycodone-related deaths dropped 25 percent after Florida implemented its Prescription Drug Monitoring Program in late 2011 as part of its response to the state's prescription drug abuse epidemic, according to a team of UF Health researchers. The drop in fatalities could stem from the number of health care providers who used the program's database to monitor controlled substance prescriptions.

16 Apr 2015

Pathology News and Research

Further Reading

ATA guidelines provide recommendations for managing thyroid nodules and thyroid cancer in children

BMC pathologists develop protocols for processing, preserving forensic evidence

University of Birmingham researchers identify new way to tackle chronic diseases

New mathematical model to predict pharmacodynamic activity may help improve drug discovery

New collaboration brings comprehensive genomic profiling to UC Davis

Global changes in cancer cells' epigenome may determine disease progression

AACR throws spotlight on the experience of Individualized Molecular Pancreatic Cancer Therapy trial

MGH researchers find probable mechanism associated with risk of developing serious diseases

PCF announces Stupski Prize in Prostate Cancer Computational Oncology

Scientists reveal three major subsets of KRAS-mutant LUAC

CAP pathologist shares four tips for women with breast cancer

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

May issue of Red Journal focuses on role of radiation therapy in current lymphoma treatment

Groundbreaking study looks at how puberty affects voice changes in male singers

Inflammation plays causal role in neurologic changes associated with Lyme disease

Flagship Biosciences customizes assay development and tissue image analysis for advanced cell diagnostics RNAscope platform

International science team pave way for fast and accurate diagnosis of the influenza virus

Leica Biosystems announces launch of Aperio VERSA scanner at AACR annual meeting

UAB research findings may lead to better treatment for women with HER2+ breast cancer

Oxycodone-related deaths drop 25% after implementation of Prescription Drug Monitoring Program

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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