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Albert Einstein College of Medicine receives $11.2 million NIH grant to study genes associated with longevity

The National Institutes of Health (NIH) has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $11.2 million grant to study the impact of damage to DNA on aging and disease. Research funded by this grant, and conducted by a consortium of scientists, could reveal the role of genome maintenance systems in delaying aging and will begin to explore novel interventions to maintain health in old age.

28 Aug 2009

Urine LAM-ELISA's sensitivity of 50.7% in identifying TB disappoints

Urine LAM-ELISA does not appear to be useful as an independent diagnostic test for pulmonary tuberculosis (TB). A trial of the new diagnostic, described in the open access journal BMC Infectious Diseases found that it was only capable of identifying 50.7% of TB cases.

28 Aug 2009

Study reveals the mechanisms of sodium tungstate in treating diabetes

The molecular mechanisms of tungstate activity in diabetes have been uncovered. Researchers writing in the open access journal BMC Genomics have identified the pathways through which sodium tungstate improves pancreatic function and beta cell proliferation.

28 Aug 2009

Enzymes could be targeted to kill dangerous pathogens

Researchers at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have demonstrated that an enzyme that is essential to many bacteria can be targeted to kill dangerous pathogens.

28 Aug 2009

Iowa researchers modify siRNA for impacting targeted cells in cancer treatment

Small interfering RNA (siRNA), a type of genetic material, can block potentially harmful activity in cells, such as tumor cell growth. But delivering siRNA successfully to specific cells without adversely affecting other cells has been challenging.

28 Aug 2009

TRAF6 protein can activate a cell signalling molecule associated with cancer

The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The University of Texas M. D. Anderson Cancer Center report in the Aug. 28 edition of Science.

28 Aug 2009

Comprehensive review on the pharmacology of sigma receptors published in Journal of Pharmacology Therapeutics

Anavex Life Sciences Corp. ("ANAVEX" or the "Company") reports the publication of a comprehensive review of the pharmacology of sigma receptors and their possible clinical application in the peer-reviewed Journal of Pharmacology Therapeutics.

28 Aug 2009

Abbott to partner with Pfizer to develop a companion diagnostic test for non-small cell lung cancer

Abbott announced today that it has entered into an agreement with Pfizer Inc to develop a molecular diagnostic test intended to screen non-small cell lung cancer (NSCLC) tumors for the presence of gene rearrangements.

28 Aug 2009

AVI BioPharma's peptide-conjugated PMO chemistry to be discussed at two upcoming scientific meetings

AVI BioPharma, Inc., a developer of RNA-based drugs, today announced that Hong Moulton, Ph.D., Director of Discovery Research, will give oral presentations highlighting improved analogues of AVI's phosphorodiamidate morpholino oligomer (PMO) chemistry at two upcoming scientific meetings.

28 Aug 2009

Medical journal article highlights the challenges faced by healthcare providers for treating patients with non-healing wounds

Cardium Therapeutics today reported that a recent medical journal article highlights the challenges facing healthcare providers with respect to finding optimal treatments for patients with non-healing wounds.

28 Aug 2009

Kingston General Hospital adopts Sentinelle Medical's new breast imaging system through HTAIP

Dr. Morris (Mickey) Milner, President and CEO of The Health Technology Exchange (HTX), announced the successful adoption of Sentinelle Medical's new breast imaging system by Kingston General Hospital (KGH), through the HTX's Health Technology Assessment and Implementation Program (HTAIP), a program funded by the Ontario Ministry of Research and Innovation.

28 Aug 2009

CRi's Oosight imaging system used for developing a gene transfer technique to prevent inherited diseases

U.S. researchers using CRi's Oosight(TM) imaging system have developed a gene transfer technique that has potential to prevent inherited diseases passed on from mothers to their children through mutated DNA in cell mitochondria.

28 Aug 2009

Chk1 and Fbx6 play an important role for the regulation of response to chemotherapy

Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. Leave the tripwire in place for too long, though, and cancer cells will press on regardless, making them resistant to the lethal effects of certain types of chemotherapy, according to researchers at the Salk Institute for Biological Studies.

28 Aug 2009

Fatostatin lowers the activity of genes associated with cholesterol synthesis

A small molecule earlier found to have both anti-fat and anti-cancer abilities works as a literal turnoff for fat-making genes, according to a new report in the August 28th issue of the journal Chemistry and Biology, a Cell Press journal.

27 Aug 2009

Geron provides additional comments on the recent clinical hold of Spinal Cord Injury IND

Geron Corporation today provided additional comments on the recent clinical hold on its Spinal Cord Injury IND.

27 Aug 2009

Researchers reveal that nonextractable polyphenols in fruits are a major part of bioactive compounds

An international team of scientists has found that the polyphenol content of fruits has been underestimated. Polyphenol content in fruits usually refers to extractable polyphenols, but a Spanish scientist working at the Institute of Food Research in Norwich analysed apple, peach and nectarine. She found that nonextractable polyphenol content is up to five times higher than extractable compounds. This work has been published in the Journal of Agricultural and Food Chemistry.

27 Aug 2009

Study suspects involvement of PPAR-γ in gastric carcinogenesis

Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied. However, the potential therapeutic role of PPAR-γ agonists has been questioned, based on contradictory results. Studies using animal models of colon cancer found that PPAR-γ agonists increased the development of colon tumors.

27 Aug 2009

Stemedica unveils two of its latest scientific discoveries at the 2009 World Stem Cell Summit

Stemedica Cell Technologies , Inc., ("Stemedica"), a world leader in stem cell research and manufacturing (a licensed manufacturer of clinical grade biological products as licensed by the State of California Food and Drug Branch) continues to advance the stem cell industry with the presentation of two of its latest scientific discoveries at the 2009 World Stem Cell Summit.

27 Aug 2009

BMSN and ENTB collaborate with Therinjectto to develop a new immuno-therapeutic cancer vaccine

Bio-Matrix Scientific Group, Inc. and Its majority owned subsidiary Entest BioMedical Inc. announced today they have finalized a definitive agreement with Therinject LLC for the development of a new immuno-therapeutic cancer vaccine. Therinject LLC is engaged in the development of cancer treatments utilizing immunology based approaches.

27 Aug 2009

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

Fluidigm today announced that its Singapore biochip factory has manufactured and shipped more than 250 million microscopic NanoFlex™ valves. The 250 million valves built into Fluidigm’s integrated fluidic circuits (IFCs) would be equivalent to the number of valves required for all the conventional plumbing – both residential and commercial – in a metropolitan region the size of the San Francisco Bay Area.

27 Aug 2009

Cell News and Research

Albert Einstein College of Medicine receives $11.2 million NIH grant to study genes associated with longevity

Urine LAM-ELISA's sensitivity of 50.7% in identifying TB disappoints

Study reveals the mechanisms of sodium tungstate in treating diabetes

Enzymes could be targeted to kill dangerous pathogens

Iowa researchers modify siRNA for impacting targeted cells in cancer treatment

TRAF6 protein can activate a cell signalling molecule associated with cancer

Comprehensive review on the pharmacology of sigma receptors published in Journal of Pharmacology Therapeutics

Abbott to partner with Pfizer to develop a companion diagnostic test for non-small cell lung cancer

AVI BioPharma's peptide-conjugated PMO chemistry to be discussed at two upcoming scientific meetings

Medical journal article highlights the challenges faced by healthcare providers for treating patients with non-healing wounds

Kingston General Hospital adopts Sentinelle Medical's new breast imaging system through HTAIP

CRi's Oosight imaging system used for developing a gene transfer technique to prevent inherited diseases

Chk1 and Fbx6 play an important role for the regulation of response to chemotherapy

Fatostatin lowers the activity of genes associated with cholesterol synthesis

Geron provides additional comments on the recent clinical hold of Spinal Cord Injury IND

Researchers reveal that nonextractable polyphenols in fruits are a major part of bioactive compounds

Study suspects involvement of PPAR-γ in gastric carcinogenesis

Stemedica unveils two of its latest scientific discoveries at the 2009 World Stem Cell Summit

BMSN and ENTB collaborate with Therinjectto to develop a new immuno-therapeutic cancer vaccine

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

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