CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

Readers and tweeters shed light on vaccine trials and bias in health care

In the piece about the AstraZeneca vaccine trial subject who suffered severe spinal cord inflammation, that person was repeatedly referred to as a "patient" ("NIH 'Very Concerned' About Serious Side Effect in Coronavirus Vaccine Trial," Sept. 14).

28 Oct 2020

Researchers present COVID RdRp structure at 2.5A

In a recent bioRxiv* preprint publication, Christopher J. Russo et al. report the structure of favipiravir ribonucleoside triphosphate (favipiravir-RTP) in complex with the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) bound to a template: primer RNA duplex. They determine the structure by electron cryomicroscopy (cryoEM) to a resolution of 2.5 Å.

26 Oct 2020

New model of human brain networks sheds light on how the brain functions

A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

20 Oct 2020

Molecular simulations reveal detailed structure and dynamics of SARS-CoV-2 spike protein

Recently, researchers reported a study in which they analyzed the structure and dynamics of the spike protein using multiple molecular dynamic simulations. Their study is published on the preprint server bioRxiv.

19 Oct 2020

Suramin shows promise as COVID-19 treatment

A new study published on the preprint server bioRxiv reports the elucidation of the mechanism of inhibition of SARS-CoV-2 by a non-nucleotide inhibitor called suramin. This is the first such compound to be shown to have such activity and shows promise for use as a repurposed drug against COVID-19.

12 Oct 2020

Why do we need sleep?

In this interview, Dr. Gina Poe speaks to News-Medical about why we sleep, and the importance of REM sleep for brain development.

7 Oct 2020

NIH awards $3.8 million to predict dementia in patients with Parkinson's disease

The National Institute of Neurological Disorders and Stroke at the National Institutes of Health has awarded a grant expected to total $3.8 million to Virendra Mishra, Ph.D., associate staff at Cleveland Clinic Lou Ruvo Center for Brain Health, to identify biomarkers - or disease indicators - to predict dementia in patients with Parkinson's disease.

6 Oct 2020

Study: Hospital-based specialist palliative care may improve patient satisfaction, depression

A Cochrane Review into the effectiveness of hospital-based specialist palliative care has found evidence that when compared to usual care, it may slightly improve patient satisfaction and depression, and increase the chances of patients dying in their preferred place (measured by home death).

1 Oct 2020

Combined study results present a strong case for lung cancer screening in New Zealand

Newly released study results present a strong case for lung cancer screening in New Zealand - particularly for Māori whose mortality rates are between three and four times higher than other ethnic groups.

29 Sep 2020

As fires and floods wreak havoc on health, new climate center seeks solutions

For the past month, record-breaking wildfires have torched millions of acres from the Mexican border well into Canada, their smoke producing air so toxic that millions of people remained indoors for days on end while many visited hospitals because of respiratory distress.

24 Sep 2020

FDA proposes updates to clarify evidence related to 'intended use' of FDA-regulated products

Today, we proposed updates to our regulations to clarify the types of evidence the FDA considers when determining the "intended use" of a product.

22 Sep 2020

Acquisition of a natural mutation primes SARS-CoV-2 for neutralization by a cross-reactive antibody

A team of scientists from the United States reveals that the acquisition of a natural mutation makes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptible to neutralization by a cross-reactive SARS-CoV antibody. The study is currently available on the bioRxiv* preprint server.

22 Sep 2020

EMPAIA project aims to build a platform for AI-assisted solutions

The EMPAIA project, which is led by Charité - Universitätsmedizin Berlin, has been crowned one of the winners of the AI Innovation Competition organized by the Federal Ministry for Economic Affairs and Energy (BMWi).

18 Sep 2020

UVA radiation may contribute to inactivation of SARS-CoV-2 by sunlight

An international team of researchers has made important discoveries about the sunlight inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that suggest this process is not currently adequately understood.

9 Sep 2020

Study shows how inhibitory learning enables memories to be stable over time

In years to come, our personal memories of the COVID-19 pandemic are likely to be etched in our minds with precision and clarity, distinct from other memories of 2020.

9 Sep 2020

BCG vaccine offers protection for elderly people against respiratory infections

The BCG vaccine has a broad, stimulating effect on the immune system. This gives it an effective preventive action against various infections - possibly also against COVID-19. New studies are investigating that.

1 Sep 2020

Younger cycad seeds pose greater risk for toxicity, study reveals

University of Guam research has revealed that younger cycad seeds pose a greater risk for toxicity when consumed than more mature seeds, bringing the scientific community one step closer to understanding the origins of a neurodegenerative disease prevalent on Guam in World War II and closer to understanding related neurological disorders elsewhere.

31 Aug 2020

Cochlear implants should be offered to adults with moderate to severe or worse hearing loss

An international group of hearing specialists has released a new set of recommendations emphasizing that cochlear implants should be offered to adults who have moderate to severe or worse hearing loss much more often than is the current practice.

27 Aug 2020

Higher COVID-19 risk perception among older American adults

In a new study published on the preprint server medRxiv*, researchers from the Yale Institute for Global Health analyzed the shift in COVID-19 risk perception, behavior, knowledge, and attitude across the U.S. from February to May 2020 by surveying 672 adults.

25 Aug 2020

Experts create three-part plan to help doctors better care for comatose patients

Leading coma experts have created an ambitious plan to help doctors better care for comatose patients and answer that most awful question: “Will my loved one wake up?”

19 Aug 2020