Immune Response News and Research

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Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Predicting how patients will respond to anti-cancer therapies can be vital in informing clinical decisions and improving treatment outcome.

15 Dec 2017

Mosquito-infected monkeys may provide better understanding of Zika transmission routes

Monkeys who catch Zika virus through bites from infected mosquitoes develop infections that look like human Zika cases, and may help researchers understand the many ways Zika can be transmitted.

14 Dec 2017

Study: Living Lyme disease bacteria found months after antibiotic treatment

Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the US, today announced results of two papers published in the peer-reviewed journals PLOS ONE and American Journal of Pathology, that seem to support claims of lingering symptoms reported by many patients who have already received antibiotic treatment for the disease.

14 Dec 2017

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Inflammatory bowel disease (IBD), including the two conditions ulcerative colitis and Crohn's disease, results in long-term inflammation of the gut and is associated with dysregulation of the immune system.

13 Dec 2017

Cellular self-digestion process plays role in development of autoimmune diseases

Autophagy allows cells to degrade and recycle their cellular components. Researchers at UZH have now demonstrated that the autophagy machinery in certain immune cells leads to the immune system attacking the central nervous system.

13 Dec 2017

Single-dose oral vaccine could be effective tool in controlling cholera outbreaks

Each year there are more than three million cases of cholera worldwide, a disease transmitted through contaminated food and water that hits developing countries particularly hard.

12 Dec 2017

Study reveals how the body clock and time of day may influence autoimmune conditions

Insights into how the body clock and time of day influence immune responses are revealed today in a study published in leading international journal Nature Communications.

12 Dec 2017

Scientists develop software that predicts leukemia-specific immune targets

University of North Carolina Lineberger Comprehensive Cancer Center scientists have developed a software program that can accurately predict which tumor-specific markers will show up on the surface of leukemia cells in patients who have received stem cell transplants.

11 Dec 2017

Novel compound along with checkpoint inhibitors may enhance immune response in melanoma patients

A novel compound may restore immune response in patients with melanoma, according to a study presented at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

Gene therapy shows promising effect against blood clots, study states

A new study conducted in the Children's Hospital Of Philadelphia (CHOP) reported positive results in a phase 1/2 clinical trial for the inherited bleeding disorder hemophilia B.

8 Dec 2017

Stress in early life may raise risk of heart disease in adulthood

Stress in early life may change the immune response in the kidneys, increasing the risk of heart disease later in life, according to a new study. The paper, published ahead of print in the American Journal of Physiology- Renal Physiology, was chosen as an APSselect article for December.

7 Dec 2017

Severely preterm children with HRV have lower airway obstruction linked to retractions, wheezing

Human rhinovirus (HRV), the culprit behind most colds, is the leading cause of hospitalization for premature babies. However, in very preterm children, exactly how HRV causes severe respiratory disease -- and which patients may need more intensive observation and treatment -- is less well understood.

7 Dec 2017

New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Immune-boosting drug combination may hold promise for treating ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone.

5 Dec 2017

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

The investigational Zika purified inactivated virus (ZPIV) vaccine was well-tolerated and induced an immune response in participants, according to initial results from three Phase 1 clinical trials.

5 Dec 2017

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against an abnormally shaped protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers.

4 Dec 2017

Research could contribute to development of therapeutic drug and vaccine against malaria

Malaria is one of three major infectious diseases affecting approximately 300 million people every year, accounting for about 500,000 deaths, but effective vaccine development has not been successful.

4 Dec 2017

Study suggests novel approach to predict respiratory allergy in children

A new study in EBioMedicine by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna, Austria suggests that immune response in early childhood to a handful of allergen molecules can predict the onset of allergic rhinitis and asthma in adolescence.

4 Dec 2017

Scientists use computer analysis to complete antibody blueprint

Antibodies defend our bodies against intruders. These molecules consist of proteins with attached sugars. However, the blueprint directing the processing of these sugars on the protein was not well understood until now.

30 Nov 2017

New vaccine technique can effectively combat breast cancer, mice study shows

A new vaccine technique can fight a certain type of breast cancer in mice. So-called HER2-positive breast cancer accounts for between 20 and 30 per cent of all cases of breast cancer in humans.

30 Nov 2017

Immune Response News and Research

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Mosquito-infected monkeys may provide better understanding of Zika transmission routes

Study: Living Lyme disease bacteria found months after antibiotic treatment

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Cellular self-digestion process plays role in development of autoimmune diseases

Single-dose oral vaccine could be effective tool in controlling cholera outbreaks

Study reveals how the body clock and time of day may influence autoimmune conditions

Scientists develop software that predicts leukemia-specific immune targets

Novel compound along with checkpoint inhibitors may enhance immune response in melanoma patients

Gene therapy shows promising effect against blood clots, study states

Stress in early life may raise risk of heart disease in adulthood

Severely preterm children with HRV have lower airway obstruction linked to retractions, wheezing

New first line combination therapy shows promising results in patients with advanced NSCLC

Immune-boosting drug combination may hold promise for treating ovarian cancer

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Research could contribute to development of therapeutic drug and vaccine against malaria

Study suggests novel approach to predict respiratory allergy in children

Scientists use computer analysis to complete antibody blueprint

New vaccine technique can effectively combat breast cancer, mice study shows

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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