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New hereditary spastic paraplegia research

In work reported this week, researchers have taken our understanding of HSP to a new level with the development of an animal model for the disease.

13 Jul 2004

Research provides new insight into the carefully controlled architectural changes that underlie organ development

A new research study demonstrates that a single chemical growth factor orchestrates a complex developmental process by sequentially activating distinct subsets of molecular signals.

13 Jul 2004

Molecular mechanisms behind XsalF's anterior specifying activity

Embryologists have long been interested in working out the means by which this regionalization is achieved, and for years the dominant theory has involved a two-step mechanism in which neural tissues are first induced lengthwise down the entire body axis, followed by a transformation step where a second signal specifies the posterior identities of the neural tissue

13 Jul 2004

Congenital heart disease (CHD) is a leading cause of mortality in children worldwide

Congenital heart disease (CHD) is a leading cause of mortality in children worldwide. According to the American Heart Association, Congenital cardiovascular defects are present in about one percent of live births and are the most common malformations in newborns.

12 Jul 2004

Cell Therapeutics receives Fast Track Designation for Pixantrone, treatment for aggressive non-Hodgkin's lymphoma

Cell Therapeutics, Inc. has received fast track designation from the U.S. Food and Drug Administration (FDA) for pixantrone, a novel anthracenedione, being investigated for the potential treatment of relapsed, aggressive non-Hodgkin's lymphoma (NHL).

12 Jul 2004

Study evaluates effectiveness of LEXIVA/ritonavir and Lopinavir/ritonavir in protease inhibitor

HIV treatment regimens containing the protease inhibitor (PI) LEXIVA® (fosamprenavir calcium) dosed with ritonavir (LEXIVA/r) or lopinavir (LPV) and ritonavir (LPV/r) were effective in suppressing HIV in patients who had failed prior PI-containing regimens, according to information presented at the International AIDS Conference (IAC).

12 Jul 2004

Increasing evidence a virus may play a role in breast cancer

A new study finds increasing evidence a virus may play a role in breast cancer. The study finds nearly three-quarters of a small sample of Tunisian breast cancer patients showed evidence of a virus similar to one known to cause breast cancer in mice, twice the rate seen in women in the United States.

12 Jul 2004

Evidence that new anti-inflammatory drug may sensitize leukemia, and breast and lung cancers to conventional chemotherapy

Ohio researchers have used a recently developed anti-inflammatory drug as a starting point to construct a possible new, targeted anti-cancer agent.

10 Jul 2004

First successful gene therapy that mimics the action of calcium channel blockers

Their findings - published in the latest edition of Circulation Research, online July 8 - may lead to a gene therapy alternative to calcium channel blockers and their sometimes severe side effects, but also further interest in the development of gene therapies unique - as in this case - to one particular organ.

10 Jul 2004

The structure of AGT shows how one human protein reduces the potency of chemotherapy

The fine details of this x-ray structure may help scientists find ways to fight certain cancers, such as brain tumors, which express high levels of AGT making them resistant to chemotherapy.

9 Jul 2004

Anal cancer is on the rise in both sexes

Anal cancer is on the rise in both sexes, particularly among American men, and changing trends in sexual behavior — combined with current tobacco use and infection by a specific strain of the human papillomavirus — may help explain the increase.

9 Jul 2004

Possible cure for sudden infant death syndrome (SIDS)

University of Chicago researchers may have found a crucial clue to understanding and ultimately eliminating sudden infant death syndrome, the leading cause of post-neonatal mortality in the United States.

9 Jul 2004

Mitochondria in spinal cords is Lou Gehrig’s disease target according researchers

The selective killing of spinal cord neurons in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, occurs when tiny cellular components called mitochondria actively recruit a mutant disease-causing protein into specific neuron cells, according to new research by University of California, San Diego (UCSD) School of Medicine investigators.

9 Jul 2004

California church coalition lends support to Proposition 71 for stem cell research

Supporters of Proposition 71 today announced the measure has been endorsed by California Church IMPACT, the legislative advocacy sister organization of the California Council of Churches. Proposition 71, the California Stem Cell Research and Cures Initiative

9 Jul 2004

Scientists have isolated human postnatal stem cells for the first time from the fibrous tendon that holds our teeth in their sockets

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR), one of the National Institutes of Health, and their colleagues have isolated human postnatal stem cells for the first time directly from the periodontal ligament, the fibrous, net-like tendon that holds our teeth in their sockets.

8 Jul 2004

Identification of a naturally occurring genetic difference that controls the production of serotonin in the brain

Researchers at Duke University Medical Center have provided the first direct evidence in mice for the role of an enzyme that specifically controls the production of serotonin in the brain.

8 Jul 2004

Chromatin array a new technology for examining DNA

A new technique for examining DNA is giving scientists a more detailed picture of which genes have the propensity for activation, offering a new tool for understanding how genes function and possibly for diagnosing disease.

8 Jul 2004

Understanding the role of c-Jun in repairing damaged nerve cells could help treat spinal injuries and increase our understanding of cancer

Research into the action of a key cancer gene has serendipitously uncovered its vital role in nerve growth, Cancer Research UK scientists reveal in a paper published on Wednesday.

8 Jul 2004

Natural products to be developed as anti-cancer therapeutics

The licence grants Zentaris exclusive worldwide rights for the development, manufacture and marketing of disorazoles, a novel class of natural products with strong anti-cancer potential discovered by GBF researchers.

8 Jul 2004

Chemoradioimmunotherapy for advanced breast cancer

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo- and radioresistant mechanisms was by presented by Dr John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

8 Jul 2004

Cell News and Research

New hereditary spastic paraplegia research

Research provides new insight into the carefully controlled architectural changes that underlie organ development

Molecular mechanisms behind XsalF's anterior specifying activity

Congenital heart disease (CHD) is a leading cause of mortality in children worldwide

Cell Therapeutics receives Fast Track Designation for Pixantrone, treatment for aggressive non-Hodgkin's lymphoma

Study evaluates effectiveness of LEXIVA/ritonavir and Lopinavir/ritonavir in protease inhibitor

Increasing evidence a virus may play a role in breast cancer

Evidence that new anti-inflammatory drug may sensitize leukemia, and breast and lung cancers to conventional chemotherapy

First successful gene therapy that mimics the action of calcium channel blockers

The structure of AGT shows how one human protein reduces the potency of chemotherapy

Anal cancer is on the rise in both sexes

Possible cure for sudden infant death syndrome (SIDS)

Mitochondria in spinal cords is Lou Gehrig’s disease target according researchers

California church coalition lends support to Proposition 71 for stem cell research

Scientists have isolated human postnatal stem cells for the first time from the fibrous tendon that holds our teeth in their sockets

Identification of a naturally occurring genetic difference that controls the production of serotonin in the brain

Chromatin array a new technology for examining DNA

Understanding the role of c-Jun in repairing damaged nerve cells could help treat spinal injuries and increase our understanding of cancer

Natural products to be developed as anti-cancer therapeutics

Chemoradioimmunotherapy for advanced breast cancer

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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