Severe Acute Respiratory News and Research

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New study assesses COVID-19 risk among UK healthcare workers

Researchers in the UK have reported the protocol for a longitudinal study investigating the risk of adverse physical and mental health outcomes related to coronavirus disease 2019 (COVID-19) among healthcare workers from different ethnic groups.

28 Feb 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

A new study deals with the clinical and virological effects of circulating SARS-CoV-2 variants, especially as they affect vaccine efficacy.

26 Feb 2021

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

A new study by researchers at The Hebrew University of Jerusalem in Israel reports the discovery of a promising group of E channel inhibitors with significant antiviral activity. This could be developed into new treatment agents for this often-deadly virus.

26 Feb 2021

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

A new study by a team of researchers in the UK and US describes the use of a computational tool that generates all possible single amino acid substitutions in SARS-CoV-2 and predicts their effects.

26 Feb 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Researchers have developed a stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21) against SARS-CoV-2 infection in Syrian hamsters. They demonstrated the high therapeutic efficacy of this homotrimeric Nb, leveraging both intranasal and aerosol delivery.

26 Feb 2021

What is the impact of demographics and air quality on COVID-19 mortality?

A new piece of research was conducted using a wide range of variables related to demographic and environmental factors in New York State (NYS), USA. NYS consists of urban and ethnically diverse counties, some of which are population-dense while others are population-sparse.

26 Feb 2021

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Researchers evaluated the immune response in a cohort of 1,089 healthcare workers who received the Pfizer-BioNTech vaccine in Southern California.

26 Feb 2021

Mandatory public health measures to combat COVID-19 are more effective, says study

In a new study, researchers at Lundberg Health Advocates and the Johns Hopkins Bloomberg School of Public Health in the U.S. compared mandatory and voluntary implementations of shelter-in-place policies. They assessed their respective bearings on COVID-19 mortality, equity, and economic outcomes.

26 Feb 2021

Antibody and T cell response to SARS-CoV-2 persist up to 8 months: Study of Ski Resort Ischgl

The first instance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Austria was observed in the Ski resort Ischgl in early March 2020. Later, the virus spread across Austria and other countries in Northern Europe.

25 Feb 2021

Pre-existing cross-reactive HCoV antibodies could protect against SARS-CoV-2

A team of researchers from Spain and Canada recently characterized the antibody kinetics and neutralization capacity at 4 cross-sectional surveys between March and October 2020 and determined the seroprevalence in the same cohort of healthcare workers.

25 Feb 2021

Microbes could predict fatal outcomes in ventilated COVID-19 patients

The study "Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome" is available as a preprint on the medRxiv* server, while the article undergoes peer review.

25 Feb 2021

Study finds link between Googling symptoms and COVID-19 cases

Yasser El-Manzalawy and colleagues from Geisinger sought to find patterns with Google searches that could predict coronavirus spread. Based on Google search trends for nine symptoms, the team suggests their model can estimate the number of COVID-19 cases across the United States up to three weeks ahead.

25 Feb 2021

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

Researchers in Switzerland and Germany have identified host cell factors required for coronavirus replication that could serve as targets for treatment with clinically-approved drugs.

25 Feb 2021

Study pinpoints potential transmission advantage of SARS-CoV-2 variant B.1.1.7

Researchers in the UK have shown that the increased transmissibility of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.1.7 that emerged in the UK during the coronavirus disease 2019 (COVID-19) pandemic does not appear to be the result of increased viral replication or immune escape.

25 Feb 2021

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

Researchers have identified a high variability in the C-terminal end of ORF7a in SARS-CoV-2 sequences collected from around the globe. They noted that mutations result in a defective suppression of interferon and lowered replication rate.

25 Feb 2021

SNX-5422 could make an effective COVID-19 prophylactic, says study

SNX-5422 is a heat shock protein 90 (Hsp90) inhibitor currently undergoing clinical trials as a cancer therapeutic. A recent study examines the applicability of repurposing the drug towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication inhibition.

25 Feb 2021

Study reports lasting immune response in convalescent COVID-19 patients

Researchers report the cellular immune response of convalescent patients in Germany, who recovered from mild or moderate infection compared to that of healthy people with no history of COVID-19.

25 Feb 2021

Study of children hospitalized with COVID-19 shows 2% mortality

The COVID-19 pandemic caused by SARS-CoV-2 has been observed to be less serious in infants and children. However, this age group is also subject to certain complications following infection. A new study describes the findings of an observational study of children hospitalized with SARS-CoV-2 infection in several different hospitals across three countries.

25 Feb 2021

Severe Acute Respiratory News and Research

New study assesses COVID-19 risk among UK healthcare workers

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

What is the impact of demographics and air quality on COVID-19 mortality?

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Mandatory public health measures to combat COVID-19 are more effective, says study

Antibody and T cell response to SARS-CoV-2 persist up to 8 months: Study of Ski Resort Ischgl

Pre-existing cross-reactive HCoV antibodies could protect against SARS-CoV-2

Microbes could predict fatal outcomes in ventilated COVID-19 patients

Study finds link between Googling symptoms and COVID-19 cases

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

Study pinpoints potential transmission advantage of SARS-CoV-2 variant B.1.1.7

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

SNX-5422 could make an effective COVID-19 prophylactic, says study

Study reports lasting immune response in convalescent COVID-19 patients

Study of children hospitalized with COVID-19 shows 2% mortality

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