RNA Sequencing News and Research

RSS

Gut's role in gout: New study unravels microbiome's influence on uric acid levels

In a comprehensive study, researchers explored the causal relationship between the gut microbiome, serological urate levels, and gout using Mendelian randomization. The findings reveal that certain genetically predicted gut microbial taxa influence uric acid levels and gout development, and vice versa, suggesting the gut microbiome as a potential therapeutic target for gout.

9 Oct 2023

Progress and challenges in completing the human gene catalogue

A group of authors reviewed the progress and challenges in annotating the human genome, including protein-coding genes, isoforms, and non-coding RNAs, and advocated for a universal annotation standard for clinical use.

5 Oct 2023

New zebrafish xenograft platform could help screen for glioblastoma treatments

Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study by the Gerhardt and De Smet labs published in EMBO Molecular Medicine.

4 Oct 2023

Aventa Genomics Announces Launch of Aventa FusionPlus, the First 3D Genomics Clinical Test for Patients with Solid Cancers

Aventa™ Genomics, LLC, a clinical laboratory established as a joint venture between Arima Genomics, Inc. and Protean BioDiagnostics Inc., today announced the launch of Aventa FusionPlus, a next-generation sequencing (NGS) test for the detection of gene fusions, translocations, and rearrangements across 361 genes from formalin-fixed, paraffin embedded (FFPE) tumor tissue.

From Aventa Genomics 4 Oct 2023

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

Could infants' robust immune responses reshape future vaccination strategies?

Utilizing next-gen sequencing techniques, researchers analyzed infants' immune responses to infections, uncovering a predominant innate immune activation unlike adults and older children. This insight could steer child vaccination research and pediatric infection management strategies, potentially revolutionizing infant healthcare.

3 Oct 2023

SARS-CoV-2 infection in coronary vessels linked to cardiovascular complications

Researchers reported that the increased long-term risk of acute cardiovascular complications associated with COVID-19 is linked to SARS-CoV-2 infecting coronary vessels and inducing the formation of plaques.

3 Oct 2023

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Micro-ribonucleic acids (miRNAs) linked to cognition and Alzheimer's disease (AD).

3 Oct 2023

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

29 Sep 2023

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.

28 Sep 2023

Researchers develop new way to boost immune cells' ability to fight TB

Tuberculosis is old - ancient even. The infectious bacterial disease that plagued Old Testament Israelites and took down pharaohs was eventually stunted by vaccinations, antibiotics, and public health measures like isolation, but it hasn't been cured yet.

27 Sep 2023

Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.

27 Sep 2023

Senescent macrophages in the lung promote tumor growth, study finds

Macrophages are a type of white blood cell that are among the body's first line of defense against infection. In addition to killing harmful microorganisms, macrophages typically can initiate a response against tumors.

25 Sep 2023

Study provides insights into human 8-cell-like cells and early embryonic development

The onset of embryo-specific gene transcription, also known as embryonic genome activation (EGA), is a crucial step in the developmental journey of an organism.

22 Sep 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023

Multipronged gene therapy restores walking in mice after complete spinal cord injury

When the spinal cords of mice and humans are partially damaged, the initial paralysis is followed by the extensive, spontaneous recovery of motor function.

21 Sep 2023

Gaining new insights into neurological diseases by studying circular RNAs in brain cells

Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells.

19 Sep 2023

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies.

18 Sep 2023

RNA Sequencing News and Research

Gut's role in gout: New study unravels microbiome's influence on uric acid levels

Progress and challenges in completing the human gene catalogue

New zebrafish xenograft platform could help screen for glioblastoma treatments

Aventa Genomics Announces Launch of Aventa FusionPlus, the First 3D Genomics Clinical Test for Patients with Solid Cancers

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Could infants' robust immune responses reshape future vaccination strategies?

SARS-CoV-2 infection in coronary vessels linked to cardiovascular complications

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Researchers develop new way to boost immune cells' ability to fight TB

Blocking Notch signaling pathway could reverse age-related bone loss

Senescent macrophages in the lung promote tumor growth, study finds

Study provides insights into human 8-cell-like cells and early embryonic development

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Multipronged gene therapy restores walking in mice after complete spinal cord injury

Gaining new insights into neurological diseases by studying circular RNAs in brain cells

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

Sequencing & Genomics: Elevating Science and Healthcare eBook

Latest eBooks

New horizons in drug discovery: High-throughput & target-to-therapy advances

A practical guide to lipid nanoparticle formulation and resizing

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology