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Human heart cells show remarkable adaptability during and after spaceflight

Heart muscle cells derived from stem cells show remarkable adaptability to their environment during and after spaceflight, according to a study publishing November 7 in the journal Stem Cell Reports.

8 Nov 2019

Oxygen-deprived tumor cells have survival advantage that promotes metastasis

Using cells from human breast cancers and mouse breast cancer models, researchers at the Johns Hopkins Kimmel Cancer Center say they have significant new evidence that tumor cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream.

7 Nov 2019

Risky strategy allows malaria parasite to quickly respond to unpredictable changes

The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.

31 Oct 2019

Scientists modify a toxic protein to create a biosensor

Researchers have shown that the pore-forming toxin (PFT), aerolysin, could be used as a biosensor in the sequencing of DNA and proteins.

30 Oct 2019

Dynamic molecular signaling waves control embryonic fates

Timing is everything for young cells waiting to determine their identities.

29 Oct 2019

Ultraviolet B light is good for the gut microbiome

A small study published in the journal Frontiers in Immunologyon October 24, 2019, shows that exposure to ultraviolet B (UVB) light, which is commonly achieved through sunlight exposure, can trigger specific beneficial changes in the gut microbiome, which are dependent on the preceding serum levels of vitamin D.

24 Oct 2019

Unhealthy gut microbiome reduces brain synaptic pruning, impairs learning

A new study by Weill Cornell Medicine and Cornell University has come up with more explanations of how gut microbes communicate with the brain neurons. The study, published in the journal Nature on October 23, 2019, examined the brains of mouse models and found that when the gut microbiome is significantly reduced, there are changes in gene expression in the brain’s microglial cells.

24 Oct 2019

Study shows link between high-fat diet and earlier appearance of Alzheimer's markers in the brain

Once it begins, Alzheimer's disease progresses systematically and aggressively, attacking victims on multiple fronts. But scientists studying the disease operate the same way - like Kent State University's own Gemma Casadesus Smith, Ph.D.

17 Oct 2019

Cell discovery could help fight against liver disease

Scientists have identified new sub-types of cells that, when they interact, accelerate the scarring process in diseased livers.

9 Oct 2019

Study reveals link between alterations in RNA splicing and Alzheimer's disease

A collaborative study published today in the journal Cell Reports provides evidence for a new molecular cause for neurodegeneration in Alzheimer's disease.

8 Oct 2019

Spatial Gene Expression Profiling of Neurological Disorders

In this interview, Cedric Uytingco discusses the key benefits of being able to visualize gene expression patterns in neurological samples.

From 10x Genomics, Inc. 7 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

New study helps better understand how type 2 diabetes progresses as a disease

Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes.

1 Oct 2019

Mount Sinai researchers discover drug resistance signature in Crohn's disease

By mapping out more than 100,000 immune cells in patients with Crohn's disease, Mount Sinai researchers have discovered a signature of cells that are involved in a type of the disease that does not respond to treatment, according to a study published in Cell in August.

29 Aug 2019

RNA sequencing data added to robust study of Parkinson's disease

A team at the Keck School of Medicine of USC, in collaboration with The Michael J. Fox Foundation for Parkinson's Research, has just added a crucial new element - RNA sequencing data -- to its robust study of Parkinson's disease.

22 Aug 2019

Research explains why many psychiatric drugs that work in the lab don’t work in people

Current drug development for neuropsychiatric disorders is in crisis, say experts. More than 90 percent of all drugs that are developed for illnesses like schizophrenia, depression, Alzheimer’s disease (AD), or the brain tumor glioblastoma complete successful trials in mice but then come to a grinding halt in human trials, wasting billions of dollars in drug research. This is partly because of obvious behavioral differences between the two species.

22 Aug 2019

Researchers gain new insights into the mechanism of vaccine-induced T cell immunity

A team led by the Walter Reed Army Institute of Research has gained new insights into the mechanism of vaccine-induced T cell immunity utilizing single-cell RNA sequencing and metabolic profiling techniques.

16 Aug 2019

Study reveals surprising discoveries about poorly understood glioblastoma

Glioblastoma, a cancer that arises in the brain's supporting glial cells, is one of the worst diagnoses a child can receive. The grade IV, highly malignant tumor aggressively infiltrates healthy brain tissue, and most children die of the disease within one to two years of diagnosis, similar to adults.

12 Aug 2019

Study maps bone marrow niche populations and their differentiation paths

Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential to produce bone, fat and cartilage.

1 Aug 2019

Researchers unlock the key to clearly identifying diseased beta cells in type 2 diabetes

Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes. This discovery has both research and therapeutic implications.

30 Jul 2019