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Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

research group led by Dr. Soichi Sano, a specially appointed lecturer in the Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka Metropolitan University, revealed that men with hematopoietic mosaic loss of Y chromosome (mLOY) — meaning men with an increase, in the blood, of cells that have lost the male sex chromosome — have a worse prognosis for heart failure due to fibrosis progression in the heart.

15 Jul 2022

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Why a condition that frequently occurs in aging men, in which an increasing number of hematopoietic cells display a loss of the Y chromosome, is associated with increased risk of mortality and age-related diseases is now a little clearer, thanks to work in mice.

15 Jul 2022

Y chromosome loss in men can lead to deadly heart failure, research shows

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.

14 Jul 2022

What is the association between long-term salt usage behavior and risk of premature mortality?

Researchers assessed the impact of increased salt consumption on life expectancy.

14 Jul 2022

Adding salt to foods at the table increases risk of premature death

People who add extra salt to their food at the table are at higher risk of dying prematurely from any cause, according to a study of more than 500,000 people, published in the European Heart Journal today (Monday).

9 Jul 2022

The association between handgrip strength and dementia risk in a UK population of middle-aged adults

Researchers analyzed the correlations between HGS, dementia, and neurocognitive outcomes among males and females from the United Kingdom.

27 Jun 2022

New study provides 'big picture' of the genetic landscape of Europe

A new study by RCSI University of Medicine and Health Sciences examining population genetics across Europe has analyzed the diverse ancestries of people living in the UK. This knowledge has the potential to inform future health research on genetic factors leading to disease.

13 Jun 2022

Coffee drinking causes no increased risk to pregnancy, genetic study reveals

University of Queensland researchers have found enjoying a daily latte or long black causes no increased risk to pregnancy.

13 Jun 2022

Discovery could lead to a simple screening process for predicting heart attack risk

Combining information about the pattern of blood vessels in the retina with genetic data can enable accurate prediction of an individual's risk of coronary artery disease (CAD) and its potentially fatal outcome, myocardial infarction (MI), commonly known as a heart attack.

13 Jun 2022

One in 500 men may carry an extra X or Y chromosome which could increase risk of several diseases

Around one in 500 men could be carrying an extra X or Y chromosome – most of them unaware – putting them at increased risk of diseases such as type 2 diabetes, atherosclerosis and thrombosis, say researchers at the universities of Cambridge and Exeter.

10 Jun 2022

Multiple heart-related conditions may increase dementia risk to a greater extent than genetics

Having multiple conditions that affect the heart are linked to a greater risk of dementia than having high genetic risk, according to a largescale new study.

9 Jun 2022

The association between vitamin D status and infections, hospitalization, and mortality due to COVID-19

Researchers explored the associations between vitamin D levels and SARS-CoV-2 infections, hospitalizations, and deaths in England.

8 Jun 2022

Research explores effects of iron status on risk of sepsis and severe COVID-19

In a recent article posted to the medRxiv* preprint server, investigators demonstrated a link between high iron status and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- and sepsis-linked hospitalizations.

7 Jun 2022

Diabetes drug's target protein can be a candidate for the treatment of Alzheimer's disease

Mechanisms associated with a particular diabetes drug can also help to protect against Alzheimer's disease, a study by researchers at Karolinska Institutet in Sweden and published in Neurology reports.

3 Jun 2022

Unsweetened and sugar-sweetened coffee drinkers may have lower risk of death

A cohort study has found that compared to non-coffee drinkers, adults who drank moderate amounts (1.5 to 3.5 cups per day) of unsweetened coffee or coffee sweetened with sugar were less likely to die during a 7-year follow up period.

31 May 2022

Normal brain aging accelerated by 26% in people with progressive type 2 diabetes, study shows

Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease, reports a study published today in eLife.

24 May 2022

Genetics and environmental factors contribute to how socioeconomic status shapes the brain architecture

Your education, your job, your income, the neighborhood you live in: Together these factors are considered to represent socioeconomic status (SES) and contribute to a variety of health and social outcomes, from physical and mental health to educational achievement and cognitive capacities.

18 May 2022

Health screening and genetic tests may help detect people who carry a gene for familial hypercholesterolemia

Health screening and genetic tests might identify more than 1 million U.S. adults who carry a gene for familial hypercholesterolemia, a common genetic disorder that causes elevated low-density lipoprotein (LDL) cholesterol, known as "bad cholesterol," which may lead to premature heart attack or death, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

18 May 2022

Inflammation plays a key role in resolving pain

In a recent study published in the journal Science Translational Medicine, researchers explored the mechanisms underlying the transition from acute to chronic low back pain (LBP) by transcriptome-wide analysis of peripheral immune cells from acute LBP patients.

17 May 2022

Deep learning reveals genetic determinants of COVID-19-associated mortality

In a recent study posted to the medRxiv* preprint server, researchers applied deep learning methods and identified genetic variants linked to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-caused mortality.

11 May 2022

UK Biobank News and Research

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Y chromosome loss in men can lead to deadly heart failure, research shows

What is the association between long-term salt usage behavior and risk of premature mortality?

Adding salt to foods at the table increases risk of premature death

The association between handgrip strength and dementia risk in a UK population of middle-aged adults

New study provides 'big picture' of the genetic landscape of Europe

Coffee drinking causes no increased risk to pregnancy, genetic study reveals

Discovery could lead to a simple screening process for predicting heart attack risk

One in 500 men may carry an extra X or Y chromosome which could increase risk of several diseases

Multiple heart-related conditions may increase dementia risk to a greater extent than genetics

The association between vitamin D status and infections, hospitalization, and mortality due to COVID-19

Research explores effects of iron status on risk of sepsis and severe COVID-19

Diabetes drug's target protein can be a candidate for the treatment of Alzheimer's disease

Unsweetened and sugar-sweetened coffee drinkers may have lower risk of death

Normal brain aging accelerated by 26% in people with progressive type 2 diabetes, study shows

Genetics and environmental factors contribute to how socioeconomic status shapes the brain architecture

Health screening and genetic tests may help detect people who carry a gene for familial hypercholesterolemia

Inflammation plays a key role in resolving pain

Deep learning reveals genetic determinants of COVID-19-associated mortality

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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