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Peptilogics held pre-IND meeting with FDA to develop PLG0206 for treating prosthetic joint infections

Peptilogics, a development stage company utilizing its innovative peptide platform to treat multidrug-resistant bacterial infections, today announced it recently held a pre-Investigational New Drug (pre-IND) meeting with the U.S. Food and Drug Administration to discuss the regulatory pathway for the development of PLG0206 for the treatment of prosthetic joint infections.

25 Aug 2018

New pharmacologic approach discovered to stop immune cell death

Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory bowel disease, and arthritis.

24 Aug 2018

INRS professors develop innovative strategy to identify leishmanicidal molecules

Leishmania is a microorganism that enters the human body via a sandfly bite. Instead of fleeing the white blood cells deployed by the immune system to destroy it, the parasite allows itself to be swallowed up.

24 Aug 2018

Gut microbial signature may help identify causes of chronic malnutrition in children

Chronic malnutrition, usually associated with an inflammation of the small intestine, affects one in every four children under the age of five. It is the leading cause of child mortality in low-income countries and is also responsible for severe stunting.

24 Aug 2018

Study finds how animal guts have evolved to defend themselves from microbial attack

A new Nature Communications paper has journeyed to the inside of our insides, as a team from the Okinawa Institute of Science and Technology Graduate University has mapped the evolutionary journey of how animal guts have evolved to defend themselves from microbial attack.

24 Aug 2018

Chemists synthesize garlic ingredient from readily available components

Fresh garlic extracts contain a variety of healthy organosulfur compounds, among which ajoene forms a major oil-extractable ingredient.

24 Aug 2018

Fresh and raw diets may provide benefits for dogs, study finds

Many dog owners think of their furry companions as part of the family, and now products are available to feed them that way, too.

24 Aug 2018

Study uncovers link between gut bacteria and 'hedonic eating'

A study of 63 healthy people showed that those with elevated microbiome levels of the metabolite indole - produced when gut bacteria break down the amino acid tryptophan - had stronger function and connectivity in specific areas of the brain's reward network.

24 Aug 2018

Texas man bitten by shark being treated for flesh-eating bacteria infection

Blain Shelton, a 42-year-old Texas man was swimming around 200 yards off the shore of Boliver Island near Galveston on 9th of August when he encountered a shark.

24 Aug 2018

Far-UVC light could help prevent catheter-based and driveline infections

A specific wavelength of ultraviolet light, now delivered through light-diffusing optical fibers, is highly effective at killing drug-resistant bacteria in cell cultures, according to a new study led by David J. Brenner, PhD, a professor of radiation biophysics at Columbia University Vagelos College of Physicians and Surgeons.

24 Aug 2018

Research uncovers unexpected upside of E. coli

Best known as a pathogen that causes food poisoning or steals nutrients away from its host, the E. coli bacterium actually plays a critical role in promoting health by producing a compound that helps cells take up iron, new CU Boulder research shows.

24 Aug 2018

Antimicrobial stewardship programs in dialysis facilities can minimize infections, deaths, and costs

A new analysis indicates that implementing antimicrobial stewardship programs in out-patient dialysis facilities can lead to significant and meaningful reductions in infections caused by multidrug-resistant organisms, infection-related deaths, and costs.

24 Aug 2018

Natural enzyme found in the human lungs can biodegrade graphene

Graphene Flagship partners discovered that a natural human enzyme can biodegrade graphene. These findings could have great implications in the development of graphene-based biomedical devices.

23 Aug 2018

Medical or surgical treatment for severe heartburn prevents esophageal cancer

Medical or surgical treatment of severe heartburn prevents cancer of the esophagus, a study from Karolinska Institutet with almost one million Nordic patients reveals. The results will be published in the scientific journal JAMA Oncology.

23 Aug 2018

Neonatal immune system starts to change dramatically in response to bacteria, viruses

As soon as a baby is born, its immune system starts to change dramatically in response to the bacteria, viruses and so forth in its new environment, a phenomenon that is common to all babies, researchers from Karolinska Institutet in Sweden write in a paper published in Cell.

23 Aug 2018

Scientists demonstrate rapid immune system development in newborn babies

Using new analytical techniques, researchers have shown for the first time the dramatic development of the human immune system after birth.

23 Aug 2018

Location of proteins on bacterial surface can impact pathogenicity of pneumococcal strains

Successful pathogenic strains of pneumococci have two proteins that, owing to their location on the surface of the bacteria, enhance their survival and ability to cause disease, a study from Karolinska Institutet in Sweden published in Nature Communications, reports.

23 Aug 2018