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Researchers discover how mutations in protein network drive high-risk leukemias

Researchers have uncovered how mutations in a protein network drive several high-risk leukemias, offering new prospects for novel therapies.

14 Jun 2017

Experimental drug suppresses new defective PTEN cancer pathway, study finds

A collaboration between Saïd M. Sebti, Ph.D., chair of Moffitt Cancer Center's Drug Discovery Department, and Michele Pagano, M.D., chair of the Department of Biochemistry and Molecular Pharmacology at New York University's Langone Medical Center, led to the publication of an important study in the latest issue of Nature.

14 Jun 2017

SLU scientists discover nuclear receptor that appears to play key role in muscle regeneration

Saint Louis University researchers report in Molecular Metabolism new findings that the nuclear receptor REV-ERB appears to play a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries.

14 Jun 2017

New tools can potentially play key role in early diagnosis of systemic sclerosis

The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR) 2017 press conference highlight the use of two new tools, which can potentially play a pivotal role in the early diagnosis of Systemic Sclerosis.

14 Jun 2017

Study shows how RNA splicing errors may trigger development of ALS, FTD

The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)- rare and related neurological disorders marked by progressive deterioration of motor or cognitive abilities- may be due to errors in RNA splicing, an intermediary step for translating genetic instructions into functional proteins.

14 Jun 2017

Researchers find link between chemotherapy during childhood and cognitive problems later in life

Young adults who had chemotherapy as a child have decreased cognitive flexibility and a weaker short-term memory.

14 Jun 2017

Research may lead to more accurate and reliable diagnostic test for autoimmune disease

In autoimmune diseases, the immune system wrongly identifies its "enemy", and produces antibodies that attack the patient's own cells.

14 Jun 2017

Sterilization and cleaning methods leave residual contamination on ureteroscopes

The techniques used to clean and sterilize flexible ureteroscopes leave behind contamination including debris, residue, and bacteria, according to a new study being presented at the 44th Annual Conference of the Association for Professionals in Infection Control and Epidemiology.

14 Jun 2017

Researchers develop new method for more accurate testing of anti-cancer drugs

A method to more accurately test anti-cancer drugs has now been developed at the Sahlgrenska Academy, University of Gothenburg. The method paves the way to much earlier assessment of who benefits from a specific drug and who does not.

14 Jun 2017

Findings may contribute to better understanding of aging and cancer development

A team of researchers led by Dr. Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore at the National University of Singapore, has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, which are key players involved in cellular aging.

14 Jun 2017

New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

Medullary cystic kidney disease type 1 (MCKD1) is a rare genetic kidney disease. Despite this, because it is an autosomal dominant disease, once the mutation is in a family, many family members are affected. Current diagnostic methods discover the disease late in its development.

14 Jun 2017

New research uncovers subcellular-level changes in the brain after concussion

New research has uncovered details about subcellular-level changes in the brain after concussion that could one day lead to improved treatment.

14 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Older adults with elevated levels of brain-clogging plaques -- but otherwise normal cognition -- experience faster mental decline suggestive of Alzheimer's disease, according to a new study led by the Keck School of Medicine of USC that looked at 10 years of data.

13 Jun 2017

Cornell researchers unravel E. coli bacteria's defense secret

By tagging a cell's proteins with fluorescent beacons, Cornell researchers have found out how E. coli bacteria defend themselves against antibiotics and other poisons. Probably not good news for the bacteria.

13 Jun 2017

Researchers identify key Lassa virus structure using powerful Argonne X-rays

Before Ebola virus ever struck West Africa, locals were already on the lookout for a deadly pathogen: Lassa virus.

13 Jun 2017

NIH awards $6 million grant to Cleveland Clinic for establishing new DLB consortium

The National Institutes of Health awarded a $6 million grant to Cleveland Clinic to establish a national research consortium focused on improving the diagnosis and understanding the cause for Dementia with Lewy Bodies.

13 Jun 2017

Altered virus could help more patients to become eligible for human gene therapy trials

For many patients, participating in gene therapy clinical trials isn't an option because their immune system recognizes and fights the helpful virus used for treatment.

13 Jun 2017

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers from the Institute of Neurosciences of the UB and from IDIBAPS together with a team from the University Pierre and Marie Curie and the Institute du Fer à Moulin, published a study in Nature Communications, which demonstrates that the regulation in Pyk2, a protein-tyrosine kinase, causes alterations of the synaptic plasticity involved in memory tasks, associated with the hippocampus in mouse models of neurodegenerative diseases, such as Huntington's.

13 Jun 2017

Poor diet may fuel Alzheimer's in people who carry disease-related gene

A diet high in cholesterol, fat and sugar may influence the development of Alzheimer's disease in people who carry the ApoE4 gene, a leading risk factor for the memory-erasing disease, indicates a new USC study.

13 Jun 2017

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G Protein News and Research

Researchers discover how mutations in protein network drive high-risk leukemias

Experimental drug suppresses new defective PTEN cancer pathway, study finds

SLU scientists discover nuclear receptor that appears to play key role in muscle regeneration

New tools can potentially play key role in early diagnosis of systemic sclerosis

Study shows how RNA splicing errors may trigger development of ALS, FTD

Researchers find link between chemotherapy during childhood and cognitive problems later in life

Research may lead to more accurate and reliable diagnostic test for autoimmune disease

Sterilization and cleaning methods leave residual contamination on ureteroscopes

Researchers develop new method for more accurate testing of anti-cancer drugs

Findings may contribute to better understanding of aging and cancer development

New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

New research uncovers subcellular-level changes in the brain after concussion

UNC study uncovers crucial function of key enzyme found in virtually all organisms

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Cornell researchers unravel E. coli bacteria's defense secret

Researchers identify key Lassa virus structure using powerful Argonne X-rays

NIH awards $6 million grant to Cleveland Clinic for establishing new DLB consortium

Altered virus could help more patients to become eligible for human gene therapy trials

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Poor diet may fuel Alzheimer's in people who carry disease-related gene

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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