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Vaccine effectiveness against COVID-19 caused by Omicron and Delta SARS-CoV-2 variants in England

Researchers performed a test-negative case-control study to determine the effectiveness of BNT162b2 and ChAdOx1 COVID-19 vaccines against the Omicron and Delta variants of SARS-CoV-2.

17 Dec 2021

Effectiveness of COVID-19 vaccines among older male veterans

A new research letter assessed the effectiveness of the mRNA1273 and BNT162b2 vaccines among fully vaccinated male veterans who were 65 years of age or above from July to September 2021.

17 Dec 2021

Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Researchers evaluated primary responses in SARS-CoV-2-naïve vaccinees, as well as secondary responses in the SARS-CoV-2-infected vaccines, and observed a clear set of differences in their clinical symptoms, antibody levels, and cellular and mucosal immune responses.

17 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

A Day in the Life of A Clinical Geneticist

In this interview, we spoke to Dr. Julian Barwell, a clinical geneticist, about his day-to-day roles and responsibilities as well as his career highlights.

17 Dec 2021

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Researchers investigated the mutations reported in the Omicron variant and its likely impact on the use of therapeutic antibodies in COVID-19 treatment as well as on vaccinated individuals.

17 Dec 2021

Investigating SARS-CoV-2 genomics-informed outbreaks using new bioinformatics tools

Researchers have created a tool designed to make as much use of the overwhelming amount of SARS-CoV-2 data as possible.

17 Dec 2021

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Researchers performed a meta-analysis of the results of four previous studies estimating fold-drop in neutralization titer against Omicron to present a combined estimate of the same.

17 Dec 2021

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

A new study measured antibody levels from blood samples of vaccinated individuals and individuals who recovered from COVID-19 illness.

17 Dec 2021

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

New research details the molecular landscape of Omicron’s RBD and how it differs from the original SARS-CoV-2 strain.

17 Dec 2021

Study provides a more effective treatment approach to preventing graft-versus-host-disease

A new study led by UC Davis Health researchers showed that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease (GVHD), an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation (allo-HSCT).

16 Dec 2021

Specific diets have less effect on IBS symptoms than expected

Many IBS sufferers avoid certain types of food and often exclude gluten. However, a large new study from Chalmers University of Technology and Uppsala University, Sweden, does not show a relationship between high intake of gluten and increased IBS symptoms.

16 Dec 2021

New study demonstrates SARS-CoV-2 Omicron antibody escape

A new study examined the neutralization of virus variants using three sets of antibodies: serum from individuals vaccinated or infected with earlier variants of the virus; concentrated human antibodies from plasma donors; and approved monoclonal antibodies.

16 Dec 2021

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

A new study reports the results of a study focused on immune evasion characteristics, specifically the ability to escape neutralization by antibodies to the earlier SARS-CoV-2 variants or to the spike antigen used in COVID-19 vaccines.

16 Dec 2021

Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development.

16 Dec 2021

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

A new study assesses the safety and efficacy of SARS-CoV-2 convalescent plasma containing high titers of anti-SARS-CoV-2 antibodies as PEP.

16 Dec 2021

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

A new study found that the Omicron S protein evades antibodies with a 44-fold higher efficiency than the Delta variant's spike, rendering therapeutic antibodies ineffective and likely negatively impacting antibody protection induced by infection or double vaccination.

16 Dec 2021

Syndrome News and Research

Vaccine effectiveness against COVID-19 caused by Omicron and Delta SARS-CoV-2 variants in England

Effectiveness of COVID-19 vaccines among older male veterans

Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Identifying protein targets in SARS-CoV-2 via machine learning

A Day in the Life of A Clinical Geneticist

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Investigating SARS-CoV-2 genomics-informed outbreaks using new bioinformatics tools

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

Study provides a more effective treatment approach to preventing graft-versus-host-disease

Specific diets have less effect on IBS symptoms than expected

New study demonstrates SARS-CoV-2 Omicron antibody escape

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

Capability of BNT162b2 vaccine given in 2 or 3 doses to neutralize SARS-CoV-2 Omicron

T cell responses remain broadly robust against Omicron variant of SARS-CoV-2

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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