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Gangrene-causing bacteria show promise as cancer treatment

Researchers have found that the bacteria responsible for causing gangrene could also be used to treat patients with certain cancers.

1 Oct 2018

Study: aPKC inhibitors may provide new therapeutic option for blinding eye diseases

Many eye diseases, including diabetic retinopathy and macular degeneration, exhibit increased permeability of blood vessels in the macular (central) portion of the retina leading to abnormal fluid accumulation and vision loss.

14 Sep 2018

New study links stress with biological disease markers in leukemia patients

Patients with chronic lymphocytic leukemia who feel more stress also have more cancer cells in their blood and elevated levels of three other markers of more advanced disease.

12 Sep 2018

Mouse study suggests new therapeutic approach to treat heart failure

A heart attack triggers an acute inflammatory response, followed by resolution of inflammation and wound healing. A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death.

10 Sep 2018

Study provides insights into how harmful white blood cells form during tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues.

31 Aug 2018

Eagle Pharmaceuticals completes enrollment of second clinical study to evaluate safety, efficacy of RYANODEX

Eagle Pharmaceuticals, Inc. today announced completion of enrollment of the Company's second clinical study to further evaluate the safety and efficacy of RYANODEX® (dantrolene sodium for injectable suspension) for the treatment of exertional heat stroke, an investigational new indication for the product.

30 Aug 2018

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Most neurons in the human brain live out their lives, enduring the processes of aging before eventually dying. Some, however, choose a more violent route: suicide.

24 Aug 2018

Injecting vasoactive intestinal peptide into the eye enhances corneal graft survival

A new study in the American Journal of Pathology reports for the first time that injection of neuropeptide vasoactive intestinal peptide directly into the eye of mice enhanced corneal graft survival.

7 Aug 2018

Doxorubicin drug causes heart toxicity by disrupting the immune system

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure.

7 Aug 2018

Study reveals how M. tuberculosis escapes death in macrophages

The bacteria that cause the devastating disease tuberculosis have the ability to escape destruction and grow after they are engulfed by lung macrophages, the immune cells that are supposed to destroy pathogens.

10 Jul 2018

Study offers new hope for people with disabling Dupuytren's disease

Researchers at the Kennedy Institute and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, working with clinicians at NHS Lothian, have found that injection of the anti-TNF drug adalimumab into Dupuytren's disease nodules results in the reduction of the cell characteristics responsible for progression of Dupuytren's disease.

9 Jul 2018

Study: Oxidative stress can be used against tumors to treat cancer

Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report.

21 Jun 2018

Study: Rheumatoid Arthritis patients with depression have increased risk of disease flare

Research from the Department of Inflammation Biology, School of Immunology & Microbial Sciences has shown there is an increased risk of disease flare in Rheumatoid Arthritis patients who suffer from depression.

19 Jun 2018

Combination of NSAIDs and TNF inhibitors linked to reduced radiographic progression in AS patients

Celecoxib combined with TNF inhibitors was associated with the greatest reduction in radiographic progression.

14 Jun 2018

Synthetic cannabis use may increase risk of heart attack and stroke

The warning follows their treatment of a 25 year old prison inmate who had no family history of heart disease or traditional cardiovascular risk factors, and who was left with a permanent disability.

8 Jun 2018

Researchers report on the sweet side of snake venom toxins

A bite from a lancehead snake can be fatal. Species in the family, found throughout Central and South America, have venom that can disrupt blood clotting and cause hemorrhage, strokes and kidney failure.

4 Jun 2018

Researcher develops nanoparticle-based tags to detect viruses and cancer with high sensitivity

How can we detect cancer and viruses with high sensitivity? Physical chemist Laura Fabris-;an associate professor in the Materials Science and Engineering Department at Rutgers, the State University of New Jersey, and principal investigator of the Fabris NanoBio Group-;is addressing this very question.

22 May 2018

Study: Psoriasis patients taking Humira show no change in aortic inflammation

An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation – a key marker of future risk of major cardiovascular events – unlike other antibodies that target different aspects of the immune system.

18 May 2018

Expectant mothers may use RA drugs without increased health risks to unborn babies

A new study led by a team at the Research Institute of the MUHC in Montreal has revealed that pregnant women with rheumatoid arthritis may be able to use certain RA drugs without possible increased health risks to their unborn babies.

17 May 2018

Key metabolites shed by gut bacteria can help protect from inflammation, study finds

Researchers at Tufts University have elucidated a mechanism by which the "good" bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease.

4 May 2018