RNA Sequencing News and Research

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Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

UBQLN2 dysfunction in ALS leads to elevated PEG10 levels, suggesting a role for retrotransposon activity in the disease. PEG10's nuclear localization alters gene expression involved in axon remodeling, implicating it as a contributing mechanism in ALS.

7 Jun 2023

Researchers zero in on a potential new target for malaria: Biological clocks

Health officials warn that drug resistance could wipe out recent progress against malaria, particularly in Africa and southeast Asia.

6 Jun 2023

Study pinpoints the exact location of atherosclerotic plaque rupture

A common cause of myocardial infarction and stroke is the rupture of atherosclerotic plaques. The exact location of plaque ruptures has previously been unknown, but now researchers at Lund University have mapped this.

5 Jun 2023

When Spectrometry bridges the gap between Proteomics and Biology

In this new episode of omg OMx, Kate Sumpo talks to Balyn Zaro about her research, experiences, and insights as a biologist in proteomics and spectrometry.

From Bruker Daltonics 2 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Mental health profoundly impacts inflammatory responses in the body

Study uncovered mechanisms by which psychological stress affects bowel inflammation.

30 May 2023

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

A new study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, provides a deeper understanding of the vast diversity of T cell states as well as their relationships and roles within the complex tumor microenvironment, bringing a fresh perspective to understanding immunotherapy efficacy in cancer.

29 May 2023

First systematic single-cell analysis of transcriptional variation within the T cell population

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Immune cells play important roles in mediating allograft rejection and tolerance after cardiac transplantation.

25 May 2023

Study examines the role of genetic variants across diverse ancestries in regulating gene expression

Exploring diverse ancestry is a critical factor in furthering medical research.

25 May 2023

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Abdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.

24 May 2023

National-level comprehensive mapping of high-fatality SARS-CoV-2 outbreaks in nursing homes

Researchers analyzed data from three SARS-CoV-2 outbreaks among nursing homes in Belgium.

24 May 2023

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such as methotrexate (MTX).

22 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

COVID's latest twist: New XBB variant gains strength through recombination, outsmarting immunity and amplifying fusogenicity

Research discusses the emergence of a highly diversified SARS-CoV-2 Omicron subvariant called XBB, which is spreading rapidly around the world. XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1, during the summer of 2022.

18 May 2023

Food preservative nisin: A gut game changer that safely alters microbiome composition

Nisin, a powerful bacteriocin, influences the gut microbiota and its functionality by modulating the abundance of specific bacterial groups and altering short-chain fatty acid synthesis.

18 May 2023

MSU researchers create the first annotated Montmorency tart cherry genome

Since Michigan is the nation's leading producer of tart cherries, Michigan State University researchers were searching for the genes associated with tart cherry trees that bloom later in the season to meet the needs of a changing climate.

18 May 2023

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

The gene ECHS1 encodes for enoyl-CoA hydratase short-chain 1, a mitochondrial enzyme involved in branched-chain amino acid and fatty acid metabolism.

18 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Researchers identify a major stem cell variant in lungs of patients with idiopathic pulmonary fibrosis

A pair of internationally renowned stem cell cloning experts at the University of Houston is reporting their findings of variant cells in the lungs of patients with Idiopathic Pulmonary Fibrosis (IPF) which likely represent key targets in any future therapy for the condition.

17 May 2023

Democratizing RNA sequencing: A breakthrough in cost and efficiency

CSEM has supported the Lausanne-based start-up Alithea Genomics in developing a technology capable of processing hundreds of ribonucleic acid (RNA) samples in a single tube, which translates to a significant reduction in reagents and manual effort in the overall workflow.

From CSEM 17 May 2023

RNA Sequencing News and Research

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

Researchers zero in on a potential new target for malaria: Biological clocks

Study pinpoints the exact location of atherosclerotic plaque rupture

When Spectrometry bridges the gap between Proteomics and Biology

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Mental health profoundly impacts inflammatory responses in the body

New pan-cancer T cell atlas provides a deeper understanding of complex tumor microenvironment

First systematic single-cell analysis of transcriptional variation within the T cell population

Study examines the role of genetic variants across diverse ancestries in regulating gene expression

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

National-level comprehensive mapping of high-fatality SARS-CoV-2 outbreaks in nursing homes

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

COVID's latest twist: New XBB variant gains strength through recombination, outsmarting immunity and amplifying fusogenicity

Food preservative nisin: A gut game changer that safely alters microbiome composition

MSU researchers create the first annotated Montmorency tart cherry genome

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers identify a major stem cell variant in lungs of patients with idiopathic pulmonary fibrosis

Democratizing RNA sequencing: A breakthrough in cost and efficiency

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