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Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

8 Dec 2020

Research illuminates regulatory mechanism of ubiquitin-proteasome system in DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

8 Dec 2020

Degenerative process can be reversed by practicing regular aerobic exercise, shows study

Adipose tissue is not just a simple reservoir of energy for periods of food scarcity. It contributes significantly to regulation of the metabolism, releasing various molecules into the bloodstream, including microRNAs that modulate the expression of key genes in different parts of the organism, including the liver, pancreas, and muscles.

8 Dec 2020

Measuring SARS-CoV-2 in wastewater solids could help track COVID-19 spread

Scientists have analyzed compounds in wastewater to gauge various aspects of public health, including narcotics usage, antibiotic resistance, and, more recently, the spread of SARS-CoV-2, the novel coronavirus that causes COVID-19.

7 Dec 2020

Research team develops a new decoding method for viral genes

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

7 Dec 2020

Researchers develop new approach for COVID-19 testing

Researchers from UC San Francisco and the Chan Zuckerberg Biohub have developed a new approach for COVID-19 testing that detects a distinct pattern of immune gene expression in infected individuals.

7 Dec 2020

Single-cell sequencing provides new fundamental insights into 'abdominal brain'

Researchers at Karolinska Institutet have succeeded in mapping the neuron types comprising the enteric nervous system in the intestine of mice.

7 Dec 2020

RNA mutations within common bacterium linked to invasive meningococcal disease

Researchers at Karolinska Institutet in Sweden have come one step closer toward understanding why some people become seriously ill or die from a common bacterium that leaves most people unharmed.

7 Dec 2020

UIC researchers use new approach to identify genes that cause diabetic retinopathy

In a search to discover the genetic factors underlying diabetic retinopathy, University of Illinois Chicago researchers also have identified a new approach that can be used as a template to study other diseases.

7 Dec 2020

Sensitive testing system enables rapid, reliable detection of resistance in bacteria

Researchers from the University of Basel have developed a sensitive testing system that allows the rapid and reliable detection of resistance in bacteria.

7 Dec 2020

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

A team of researchers from UK and US used the DICE database and 3D cis-interactome maps to generate a list of target genes and immune cell types that are most affected by the genetic variants associated with COVID-19 severity.

7 Dec 2020

Study reveals genetic abnormalities that cause brain aneurysms

Nearly three percent of the world's population is at risk of developing an intracranial aneurysm, a localized dilation of a blood vessel forming a fragile pocket. Rupture of this aneurysm results in extremely severe, and, in one-third of cases, fatal hemorrhage.

7 Dec 2020

Genes News and Research

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Research illuminates regulatory mechanism of ubiquitin-proteasome system in DNA damage repair

Degenerative process can be reversed by practicing regular aerobic exercise, shows study

Measuring SARS-CoV-2 in wastewater solids could help track COVID-19 spread

Research team develops a new decoding method for viral genes

Researchers develop new approach for COVID-19 testing

Single-cell sequencing provides new fundamental insights into 'abdominal brain'

RNA mutations within common bacterium linked to invasive meningococcal disease

UIC researchers use new approach to identify genes that cause diabetic retinopathy

Sensitive testing system enables rapid, reliable detection of resistance in bacteria

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

Study reveals genetic abnormalities that cause brain aneurysms

SARS-CoV-2 in Brazil shows gross genetic diversity

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

Combination of venetoclax and standard therapies shows promise in high-risk myeloid blood cancers

Researchers identify potential drug combination to treat uveal melanoma

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

Rice biochemist discovers hidden structure in essential metabolic machinery

Using gene therapy to achieve the positive health effects of physical exercise

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics