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Novel antidepressant targets brain receptors responsible for learning and memory

A first-of-its-kind antidepressant drug discovered by a Northwestern University professor and now tested on adults who have failed other antidepressant therapies has been shown to alleviate symptoms within hours, have good safety and produce positive effects that last for about seven days from a single dose.

7 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

Dendritic spines respond to and process synaptic inputs both chemically and electrically

It's the least understood organ in the human body: the brain, a massive network of electrically excitable neurons, all communicating with one another via receptors on their tree-like dendrites. Somehow these cells work together to enable great feats of human learning and memory. But how?

6 Dec 2012

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see - within individual neurons of living animals - how brain diseases disturb the transport of mitochondria, the power plants of the cell.

6 Dec 2012

TSRI scientist to better define how brain organizes different types of memories among neurons

A scientist from the Florida campus of The Scripps Research Institute (TSRI) has been awarded approximately $2.5 million from the National Institute of Neurological Disorders and Stroke to better define how the brain organizes different types of memories among its neurons.

6 Dec 2012

New method promises to boost stem cell production in laboratory

A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies that would replace damaged or unhealthy body tissues.

5 Dec 2012

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Selective targeting of the neurotransmitter that differentially affects brain cells that control the two distinct functions of the pancreas may allow for new medication therapies for conditions like diabetes, dyspepsia and gastro-esophageal reflux, according to Penn State College of Medicine researchers.

5 Dec 2012

Parasympathetic dysfunction underpins Gulf War Syndrome

Gulf War veterans with self-reported symptoms of autonomic dysfunction have objective evidence of underlying damage to central and peripheral cholinergic function, a study shows.

4 Dec 2012

Researchers derive dopaminergic neurons from bone marrow stem cells in monkeys

Parkinson's disease is a degenerative disorder of the central nervous system that is characterized by tremors, rigidity, slowness of movement, and difficulty walking. It is caused by loss of the neurons that produce the neurotransmitter dopamine (known as dopaminergic neurons). One of the primary goals in Parkinson's disease research is to develop a replacement for dopaminergic neurons.

4 Dec 2012

Stem cells give insight into path of cytomegalovirus infection

Primitive human stem cells are resistant to human cytomegalovirus, say researchers who believe this finding could provide further insight into disease pathology.

3 Dec 2012

Reduced production of myelin may play role in development of mental illness: Study

Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to researchers at the Graduate School of Biomedical Sciences at Mount Sinai School of Medicine.

1 Dec 2012

Lewy pathology out of favor as Parkinson’s culprit

Neurodegeneration and cellular dysfunction may precede the appearance of Lewy bodies in the substantia nigra, shows research that challenges the role of Lewy pathology in Parkinson’s disease.

30 Nov 2012

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

Primitive human stem cells resistant to human cytomegalovirus

A new study published online in PLOS ONE reveals that primitive human stem cells are resistant to human cytomegalovirus (HCMV), one of the leading prenatal causes of congenital intellectual disability, deafness and deformities worldwide.

30 Nov 2012

GM1 ganglioside effectively treats patients with Parkinson's disease

Treating Parkinson's disease patients with the experimental drug GM1 ganglioside improved symptoms and slowed their progression during a two and a half-year trial, Thomas Jefferson University researchers report in a new study published online November 28 in the Journal of the Neurological Sciences.

30 Nov 2012

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

30 Nov 2012

Neuro-inflammation plays a crucial role in initiating prion disease

In a recent publication, researchers of the Computational Biology group at the Luxembourg Centre for Systems Biomedicine showed that neuro-inflammation plays a crucial role in initiating prion disease.

30 Nov 2012

Microglia might play a key role in protecting brain from Alzheimer's

A new experimental study carried out in mice shows that microglia, immune cells of the brain, might play a key role in protecting the brain from Alzheimer's disease (AD).

29 Nov 2012

Reduction in myelin production may also play a role in development of mental illness

29 Nov 2012

French National Center for Scientific Research scientist wins American Epilepsy Society award

Richard Miles, Ph.D., Research Director, French National Center for Scientific Research, and Group Leader, Cortex and Epilepsy, Institute for the Brain and Spinal Cord, Centre Hospitalier Universtaire Pitie-Salpetriere, Paris, has been named recipient of the prestigious 2012 Epilepsy Research Recognition Award for Basic Science conferred by the American Epilepsy Society (AES).

28 Nov 2012

Neurons News and Research

Novel antidepressant targets brain receptors responsible for learning and memory

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Dendritic spines respond to and process synaptic inputs both chemically and electrically

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

TSRI scientist to better define how brain organizes different types of memories among neurons

New method promises to boost stem cell production in laboratory

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Parasympathetic dysfunction underpins Gulf War Syndrome

Researchers derive dopaminergic neurons from bone marrow stem cells in monkeys

Stem cells give insight into path of cytomegalovirus infection

Reduced production of myelin may play role in development of mental illness: Study

Lewy pathology out of favor as Parkinson’s culprit

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Primitive human stem cells resistant to human cytomegalovirus

GM1 ganglioside effectively treats patients with Parkinson's disease

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Neuro-inflammation plays a crucial role in initiating prion disease

Microglia might play a key role in protecting brain from Alzheimer's

Reduction in myelin production may also play a role in development of mental illness

French National Center for Scientific Research scientist wins American Epilepsy Society award

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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