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Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.

13 Mar 2024

Age-related changes in the shape of brain neurons lead to middle-age obesity

Nagoya University researchers and their colleagues in Japan have found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region of the brain that controls metabolism and appetite.

13 Mar 2024

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins - rather than one - with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Ricoh and ERS Genomics enter into CRISPR/Cas9 license agreement

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From ERS Genomics 13 Mar 2024

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.

13 Mar 2024

Exploring the power of diet: A new frontier in disease management and cancer treatment

The therapeutic potential of and molecular mechanisms through which dietary interventions impact a wide range of human diseases.

13 Mar 2024

Study reveals novel brain recovery mechanism after traumatic brain injury

A team of Medical University of South Carolina researchers, led by Onder Albayram, Ph.D., reports in PNAS Nexus that they have discovered a novel protective response by which the brain naturally repairs itself after traumatic brain injury.

13 Mar 2024

Novel tool to predict a person's risk for cardiovascular complications after bone marrow transplant

For thousands of Americans each year, a bone marrow transplant has the potential to cure diseases such as leukemias, lymphomas and immune deficiency disorders.

13 Mar 2024

New custom-designed proteins can efficiently reach intramembrane targets

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently reach these "intramembrane" targets.

13 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

Researchers receive $5 million to propel new cancer discoveries using computational biology and AI

A multidisciplinary research team at Gladstone Institutes, led by Senior Investigator Katie Pollard, PhD, has received $5 million in funding through a newly launched grant program designed to ignite a fresh wave of cancer discoveries using computational biology and artificial intelligence.

12 Mar 2024

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

12 Mar 2024

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

12 Mar 2024

Penn State team identifies distinct sleep patterns and their correlation to overall health

Poor sleep habits are strongly associated with long-term chronic health conditions, according to decades of research.

12 Mar 2024

Women with germ cell tumors have worse prognosis than men with similar cancers

Women with a type of ovarian cancer known as germ cell tumors have a worse prognosis than men with similar tumors, i.e. testicular cancer.

12 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

Cell News and Research

Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Age-related changes in the shape of brain neurons lead to middle-age obesity

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Ricoh and ERS Genomics enter into CRISPR/Cas9 license agreement

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Exploring the power of diet: A new frontier in disease management and cancer treatment

Study reveals novel brain recovery mechanism after traumatic brain injury

Novel tool to predict a person's risk for cardiovascular complications after bone marrow transplant

New custom-designed proteins can efficiently reach intramembrane targets

Limoncella apple polyphenol extract shines in IBD liver damage study

Understanding how chikungunya virus affects the brain and body

Researchers receive $5 million to propel new cancer discoveries using computational biology and AI

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Penn State team identifies distinct sleep patterns and their correlation to overall health

Women with germ cell tumors have worse prognosis than men with similar cancers

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

T1-spanin breakthrough offers new hope against antibiotic resistance

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

Discovery of new organelle could improve the understanding of chronic liver diseases

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