Genes News and Research

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Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

An international team of researchers led by Cleveland Clinic's Lerner Research Institute has performed for the first time a wide-scale characterization of missense variants from 1,330 disease-associated genes.

27 Oct 2020

UVA research sheds light on how cancer remodels our chromosomes

Cancer remodels the architecture of our chromosomes so the disease can take hold and spread, researchers at the University of Virginia have revealed.

27 Oct 2020

Study identifies 17 new genes that could be targeted for treatment of psoriasis, eczema

A Swedish study has identified 17 new genes that could be targeted for treatment of psoriasis and eczema, two common hereditary skin diseases with no cure.

27 Oct 2020

Scientists identify new therapeutic targets for SARS-CoV-2

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Lung biomarkers may predict severe COVID-19

Two University of New Mexico researchers postulate certain specific biomarkers' relevance in predicting the potential for progression to severe COVID-19 in a paper published on the preprint server bioRxiv*

27 Oct 2020

Cellular senescence variations may control health and onset of age-related diseases

Researchers from Kumamoto University, Japan have proposed that cellular senescence variations during the aging process could lead to control of health and onset of age-related diseases.

27 Oct 2020

Interaction between PTSD and klotho gene may cause premature aging in the brain

Study Finds PTSD Interacts With Klotho Gene, May Cause Premature Aging In The Brain

27 Oct 2020

Study finds new transposon-derived genes related to autism

The lack of some genes in the BEC/TCEAL cluster could be related to some alterations associated with the autism spectrum disorder, according to a preclinical study published in the journal Genome Biology, and led by Professor Jordi Garcia Fernàndez, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona, and researcher Jaime Carvajal, from the Andalusian Centre for Developmental Biology - University Pablo de Olavide.

27 Oct 2020

Genome-wide screens reveal new helpful and harmful COVID-19 related genes

Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus.

27 Oct 2020

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

In recent years, improvements in cancer therapy have led to a significant increase in cancer survivorship. Experts estimate that by 2022, the United States will have 18 million cancer survivors, but a subset of those survivors will have long-term health problems to be addressed.

27 Oct 2020

New research on small non-coding RNAs and SARS-CoV-2

A recently published mini-review in the Frontiers in Microbiology on the altered expression of small non-coding RNAs during coronavirus-mediated infections.

26 Oct 2020

Researchers generate a transcriptomic map of the COVID brain

COVID-19 is known to be associated with multiple changes in gene expression, but many of these are also seen in chronic brain conditions as well as in some abnormal mental conditions. A recent study published on the preprint server bioRxiv in October 2020 uncovers the molecular basis of this association.

26 Oct 2020

Transcriptomics identifies possible COVID-19 therapies

By using a diverse set of transcriptomic SARS-CoV-2 signatures, US researchers put to use their previously developed drug repositioning pipeline to pinpoint potential drug candidates for the treatment of coronavirus disease (COVID-19). The study is currently available on bioRxiv preprint server.

26 Oct 2020

Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

A new study published on the preprint server bioRxiv* in October 2020 reports the discovery of important viral genomic features that are crucial to its replication in the human airway cells, and its enhancing mutations which increase the rate of replication and determine its target cells.

26 Oct 2020

Researchers identify molecular processes in kidney cells that attract and feed COVID-19

Although the lungs are a common target for COVID-19's cytokine storm, so are the kidneys, making the 1 in 4 U.S. adults with diabetes resulting in diabetic kidney disease at increased risk for virus mortality.

23 Oct 2020

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

People with diabetes -- especially the 20 to 40 percent with diabetic kidney disease -- are among the most at risk for serious complications and death from COVID-19.

23 Oct 2020

Oregon biologists reveal molecular mechanisms that produce DNA damage in sperm

University of Oregon biologists have used the model organism Caenorhabditis elegans to identify molecular mechanisms that produce DNA damage in sperm and contribute to male infertility following exposure to heat.

23 Oct 2020

Researchers create AI system that matches tumors to best drug combinations

Only 4 percent of all cancer therapeutic drugs under development earn final approval by the U.S. Food and Drug Administration (FDA).

23 Oct 2020

Distinct DNA methylation signature found in the cord blood of newborns diagnosed with ASD

A new study led by UC Davis MIND Institute researchers found a distinct DNA methylation signature in the cord blood of newborns who were eventually diagnosed with autism spectrum disorder (ASD).

22 Oct 2020

Study: Antiretroviral therapy fails to restore age-appropriate epigenetic patterns

Untreated HIV infection is linked with epigenetic changes that suggest rapid aging. A new study by UCLA researchers shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses.

22 Oct 2020

Genes News and Research

Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

UVA research sheds light on how cancer remodels our chromosomes

Study identifies 17 new genes that could be targeted for treatment of psoriasis, eczema

Scientists identify new therapeutic targets for SARS-CoV-2

Lung biomarkers may predict severe COVID-19

Cellular senescence variations may control health and onset of age-related diseases

Interaction between PTSD and klotho gene may cause premature aging in the brain

Study finds new transposon-derived genes related to autism

Genome-wide screens reveal new helpful and harmful COVID-19 related genes

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

New research on small non-coding RNAs and SARS-CoV-2

Researchers generate a transcriptomic map of the COVID brain

Transcriptomics identifies possible COVID-19 therapies

Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

Researchers identify molecular processes in kidney cells that attract and feed COVID-19

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

Oregon biologists reveal molecular mechanisms that produce DNA damage in sperm

Researchers create AI system that matches tumors to best drug combinations

Distinct DNA methylation signature found in the cord blood of newborns diagnosed with ASD

Study: Antiretroviral therapy fails to restore age-appropriate epigenetic patterns

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