Embryonic Development News and Research

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Embryonic development or embryogenesis is the process by which the embryo is formed and develops. It starts with the fertilization of the ovum, egg, which, after fertilization, is then called a zygote. The zygote undergoes rapid mitotic divisions, the formation of two exact genetic replicates of the original cell, with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of an embryo.

Molecular breakdown of Bicoid protein vital for normal patterning of fruit fly's offspring

Using fruit flies as a model to study embryo formation, scientists report in Nature Cell Biology that molecular breakdown of a protein called Bicoid is vital to normal head-to-tail patterning of the insect's offspring.

22 Dec 2010

Scientists demonstrate similarity between individual development and phylogeny in level of gene expression

Similarities in the embryonic development of various animal species are also found at molecular level. The astonishing similarity in the appearance of embryos from different animal species was observed as far back as the 19th century by scientists such as Karl von Baer, Charles Darwin and Ernst Haeckel.

16 Dec 2010

Protein p53 plays crucial role in coordinated growth of organ parts

In studies conducted on the fruit fly, researchers at IRB Barcelona headed by ICREA Professor Marco Milán have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein p53 plays a crucial role. The study is published today in the prestigious journal PLoS Biology.

15 Dec 2010

Anoles key to medically applicable regeneration?

Anolis lizards first entered Arizona State University biologist Kenro Kusumi's life in 1980 when, as a member of a junior curator program, he recorded in his field notebook that he had found an Anolis egg on a field trip. Kusumi still has those notes, along with other memorabilia that document the influence that both his early life and more recent experiences have had on his current pursuits in developmental biology.

15 Dec 2010

Study shows breast inflammation promotes development and progression of cancer

It took 12 years and a creation of a highly sophisticated transgenic mouse, but researchers at Kimmel Cancer Center at Jefferson have finally proven a long suspected theory: Inflammation in the breast is key to the development and progression of breast cancer.

15 Dec 2010

New technique may help develop novel treatments for brain diseases

Scientists have created a way to isolate neural stem cells - cells that give rise to all the cell types of the brain - from human brain tissue with unprecedented precision, an important step toward developing new treatments for conditions of the nervous system, like Parkinson's and Huntington's diseases and spinal cord injury.

8 Dec 2010

Protein DEDD required for uterine decidualization during early pregnancy: Study

The mammalian embryo relies on physical connections to its mother to survive. After implantation into the wall of the uterus and before the placenta is established, a structure known as the decidua forms and is key to supporting embryonic development.

7 Dec 2010

Mirna to present data on miRNA Replacement Therapies for cancer at CPRIT Conference

Mirna Therapeutics, Inc., a leading developer of microRNA (miRNA)-based therapeutics, announced today that it will present new data at the inaugural CPRIT Innovations in Cancer Prevention and Research Conference, November 17-19, 2010 in Austin, TX.

17 Nov 2010

New findings help identify impact of prenatal environment on early parental care on brain

New findings released today help identify the long-term impact of the prenatal environment and early parental care on the brain. Using animals as models, researchers help explain why early inflammation and a mother's exposure to drugs such as nicotine and high doses of pain killers have lasting consequences for children and even future generations.

16 Nov 2010

USPTO issues Notice of Allowance to Asuragen’s mir-205 for lung cancer diagnosis

Asuragen, Inc., a leader in the development of molecular diagnostics, announced today that it had received a Notice of Allowance from the United States Patent and Trademark Office for claims related to the use of mir-205 as a diagnostic in lung cancer.

11 Nov 2010

Dysfunction of Grhl2 factor may affect epithelial barrier formation, contribute to congenital abnormalities

Scientists of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch and the Experimental and Clinical Research Center (ECRC) of MDC and Charit- in Berlin-Buch have gained new insights into the development of epithelial cells and their molecular repertoire.

30 Oct 2010

Mechanism that controls embryonic development could also prevent cancer

Researchers from Mount Sinai School of Medicine have identified a mechanism controlling the function of a protein that binds to DNA during embryonic development and may function to prevent abnormal tumor growth.

29 Oct 2010

University of Manchester receives Wellcome Trust grant for five-year study

A team investigating how genes respond to hormonal changes and inflammation has been awarded a Wellcome Trust grant of 1.24 million for a five-year study

From The University of Manchester 28 Oct 2010

Mirna announces USPTO allows claims to therapeutic application of let-7 miRNA

Mirna Therapeutics, Inc. announced today that the USPTO has allowed claims related to the therapeutic application of let-7 in the regulation of oncogenes. The claims derive from a patent application that was submitted by Yale University and exclusively licensed to Mirna related to the pioneering work of Dr. Frank Slack, Professor of Molecular, Cellular & Developmental Biology at Yale University in New Haven, CT.

20 Oct 2010

Scientists discover 'switch' mechanism of lymphatic and blood vessel cells

Scientists at the University of East Anglia have made an important breakthrough in the way anti-cancer drugs are tested. A tumour cannot grow to a large size or spread until it has developed its own blood supply and leading research has looked for a way of halting capillary formation to stop tumours taking hold.But new findings published today in the Journal of Cell Science have shown that scientists testing such treatments may not have been studying exactly what they thought they were.

14 Oct 2010

Genentech initiates GDC-0449 Phase II clinical trial in BCC patients

Curis, Inc. a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that its collaborator Genentech, a member of the Roche Group, has initiated a Phase II clinical trial of GDC-0449, an orally-administered small molecule Hedgehog Pathway Inhibitor, as a single-agent therapy for patients with operable basal cell carcinoma (BCC).

11 Oct 2010

PDGF identified as key factor in proliferation and transformation of epicardial cells

In research that one day may lead to the discovery of how to regenerate tissue damaged by heart disease, investigators at Childrens Hospital Los Angeles have identified PDGF as a key factor in the proliferation and transformation of epicardial cells, one type of cell that surrounds heart muscle and contributes to vessels.

6 Oct 2010

Platelet derived growth factor plays role in heart regeneration

6 Oct 2010

Researchers identify ways to predict embryonic developmental success

Two-thirds of all human embryos fail to develop successfully. Now, in a new study, researchers at the Stanford University School of Medicine have shown that they can predict with 93 percent certainty which fertilized eggs will make it to a critical developmental milestone and which will stall and die. The findings are important to the understanding of the fundamentals of human development at the earliest stages, which have largely remained a mystery despite the attention given to human embryonic stem cell research.

4 Oct 2010

Women & Infants Hospital receives $2.1M NIH grant to continue work under COBRE for Perinatal Biology

Women & Infants Hospital has recently received a $2.1 million grant from the National Institutes of Health to continue work under the Center of Biomedical Research Excellence for Perinatal Biology. Of the 108 COBREs across the country, Women & Infants is the only one specifically focused on developmental research.

28 Sep 2010

Embryonic Development News and Research

Further Reading

Molecular breakdown of Bicoid protein vital for normal patterning of fruit fly's offspring

Scientists demonstrate similarity between individual development and phylogeny in level of gene expression

Protein p53 plays crucial role in coordinated growth of organ parts

Anoles key to medically applicable regeneration?

Study shows breast inflammation promotes development and progression of cancer

New technique may help develop novel treatments for brain diseases

Protein DEDD required for uterine decidualization during early pregnancy: Study

Mirna to present data on miRNA Replacement Therapies for cancer at CPRIT Conference

New findings help identify impact of prenatal environment on early parental care on brain

USPTO issues Notice of Allowance to Asuragen’s mir-205 for lung cancer diagnosis

Dysfunction of Grhl2 factor may affect epithelial barrier formation, contribute to congenital abnormalities

Mechanism that controls embryonic development could also prevent cancer

University of Manchester receives Wellcome Trust grant for five-year study

Mirna announces USPTO allows claims to therapeutic application of let-7 miRNA

Scientists discover 'switch' mechanism of lymphatic and blood vessel cells

Genentech initiates GDC-0449 Phase II clinical trial in BCC patients

PDGF identified as key factor in proliferation and transformation of epicardial cells

Platelet derived growth factor plays role in heart regeneration

Researchers identify ways to predict embryonic developmental success

Women & Infants Hospital receives $2.1M NIH grant to continue work under COBRE for Perinatal Biology

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