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Scientists reveal new control mechanism for gene that causes Opitz syndrome

Opitz G/BBB (Opitz) syndrome is a hereditary disorder that affects people in different ways, causing malformations in medial (midline) organs and structures, intellectual disability and developmental disorders.

18 May 2017

Newly identified biomarkers could help predict cognitive deficits in Parkinson's disease patients

New biomarkers identified by a research team in the Perelman School of Medicine at the University of Pennsylvania could help predict which Parkinson's disease patients will suffer significant cognitive deficits within the first three years of their diagnosis.

18 May 2017

$Innovative technique could replace bone grafts to repair severe limb fractures$

Innovative technique could replace bone grafts to repair severe limb fractures

A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue.

17 May 2017

Microbes can manipulate molecular machinery of host cells to influence health

All animals -- from sea sponges to modern-day humans -- evolved in a world already teeming with microbes. These single-celled microorganisms now cover practically every surface of our bodies and are as much a part of our biology as our own tissues and organs.

17 May 2017

Researchers identify new drug target for two common types of myeloid leukemia

University of Georgia researchers, with colleagues from the University of Tokyo, have identified a new drug target for the two most common types of myeloid leukemia, including a way to turn back the most aggressive form of the disease.

17 May 2017

Experimental gene therapy proven safe for preserving vision of people with AMD

In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it may be effective in preserving the vision of people with wet age-related macular degeneration.

17 May 2017

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

By using induced pluripotent stem cells to create endothelial cells that line blood vessels in the brain for the first time for a neurodegenerative disease, University of California, Irvine neurobiologists and colleagues have learned why Huntington's disease patients have defects in the blood-brain barrier that contribute to the symptoms of this fatal disorder.

17 May 2017

Researchers discover likely cause for visual impairment in Finnish variant of NCL

Researchers from the University of Eastern Finland have discovered a likely cause for visual impairment and eventual loss of vision in the Finnish variant of Neuronal Ceroid Lipofuscinosis.

17 May 2017

Researchers identify many dangerous strains of TB pathogens

Researchers from the Vavilov Institute of General Genetics of the Russian Academy of Sciences (VIGG) and the Moscow Institute of Physics and Technology have established a catalog of mutations in 319 virulence genes of mycobacteria that cause tuberculosis.

16 May 2017

Scientists unravel mystery of T cell signaling process vital to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained a mystery.

16 May 2017

EPFL scientists develop new antibody-linked biosensor to track drug concentration in the blood

Being able to monitor drug concentration in the blood of a patient is an important aspect of any pharmaceutical treatment. However, this requires equipment and facilities that are often missing from field healthcare in developing countries, but also inhibits the quality of life for patients elsewhere.

16 May 2017

Researchers measure spread of tau protein in the brains of Alzheimer’s patients

In a new study presented in Molecular Psychiatry, researchers at Karolinska Institutet have measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer's disease.

16 May 2017

Prototype drug prevents lung cancer tumors in mice by using novel mechanism

Lung cancer tumors were prevented in mice by a novel small molecule that directly activates a tumor suppressor protein.

16 May 2017

Mayo Clinic study provides information on survival and death of patients with synucleinopathies

Faced with a serious disease, patients want to know the answer to a difficult question: "How long will I live?"

16 May 2017

Study unravels new clues to cause and treatment of spinal muscular atrophy

Spinal muscular atrophy, a neurodegenerative disease that causes progressive muscle wasting and paralysis, may be partly due to abnormalities in the synapses that connect sensory neurons and motor neurons, according to researchers at Columbia University Medical Center.

16 May 2017

Research identifies protein that could help patients respond more positively to epilepsy drug therapies

New research from the University of Liverpool, in collaboration with the Mario Negri Institute in Milan, published today in the Journal of Clinical Investigation, has identified a protein that could help patients with epilepsy respond more positively to drug therapies.

16 May 2017

Diabetes medication could potentially help treat symptoms of Fragile X syndrome

Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism.

15 May 2017

New gene variant linked to Lou Gehrig's disease

For the first time, a variant in UBQLN4 gene has been associated with Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS) - a progressive disease resulting in the loss of nerve cells that control muscle movement, which eventually leads to paralysis and death.

15 May 2017

New IsoPSA assay detects prostate cancer more precisely than current tests

A team of researchers from Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, Kaiser Permanente Northwest, and other clinical sites have demonstrated that a new blood test known as IsoPSA detects prostate cancer more precisely than current tests in two crucial measures - distinguishing cancer from benign conditions, and identifying patients with high-risk disease.

15 May 2017

Researchers develop new test that predicts need for massive blood transfusion in trauma patients

By combining a conventional laboratory measurement of blood clotting time (known as the International Normalized Ratio or INR) with a new test of blood clot strength, based upon thrombelastography (TEG), researchers at the University of Colorado's Department of Surgery, Denver, are able to quickly and efficiently assess the overall ability of blood to clot and identify trauma patients who were most in need of a massive blood transfusion.

15 May 2017

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G Protein News and Research

Scientists reveal new control mechanism for gene that causes Opitz syndrome

Newly identified biomarkers could help predict cognitive deficits in Parkinson's disease patients

Innovative technique could replace bone grafts to repair severe limb fractures

Microbes can manipulate molecular machinery of host cells to influence health

Researchers identify new drug target for two common types of myeloid leukemia

Experimental gene therapy proven safe for preserving vision of people with AMD

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Researchers discover likely cause for visual impairment in Finnish variant of NCL

Researchers identify many dangerous strains of TB pathogens

Scientists unravel mystery of T cell signaling process vital to immune response

EPFL scientists develop new antibody-linked biosensor to track drug concentration in the blood

Researchers measure spread of tau protein in the brains of Alzheimer’s patients

Prototype drug prevents lung cancer tumors in mice by using novel mechanism

Mayo Clinic study provides information on survival and death of patients with synucleinopathies

Study unravels new clues to cause and treatment of spinal muscular atrophy

Research identifies protein that could help patients respond more positively to epilepsy drug therapies

Diabetes medication could potentially help treat symptoms of Fragile X syndrome

New gene variant linked to Lou Gehrig's disease

New IsoPSA assay detects prostate cancer more precisely than current tests

Researchers develop new test that predicts need for massive blood transfusion in trauma patients

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