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Drug repurposing study finds lonafarnib effective against RSV

A study in Nature Communications identifies lonafarnib from the ReFRAME drug-repurposing library as a potent inhibitor of the RSV fusion protein, showing promise in reducing RSV infection in vitro and in vivo.

11 Feb 2024

New study finds 4’-fluorouridine effective against avian influenza in vitro and in vivo

A PLOS Pathogens study reveals 4’-fluorouridine effectively combats avian influenza in vitro and in animal models, showing promise as a treatment that overcomes resistance and reduces disease severity without significant adverse effects.

11 Feb 2024

Unlocking Alzheimer's secrets: Study pinpoints APOE4's harmful effect on lipids

UNC School of Medicine researcher Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen lab, have made a new discovery about apolipoprotein E (APOE) – the biggest genetic risk factor for late-onset Alzheimer's disease.

9 Feb 2024

Immune system in the blood of Alzheimer's patients found to be epigenetically altered

A new Northwestern Medicine study has found the immune system in the blood of Alzheimer's patients is epigenetically altered.

9 Feb 2024

Sleep apnea prevalent among cardio-oncology patients, study shows

Sleep apnea is prevalent among cardio-oncology patients who are at higher risk for congestive heart failure from cancer therapy, according to a new study being presented at the American College of Cardiology (ACC) Advancing the Cardiovascular Care of the Oncology Patient course.

9 Feb 2024

Scientists develop safer CAR T-cell strategy for treating lymphomas

In the treatment of aggressive lymphomas and blood cancer (leukaemia), so-called chimeric antigen receptor T cells (CAR T cells) are increasingly being used.

9 Feb 2024

Amputees regain temperature sensation with new prosthetic technology

Sensory feedback is important for amputees to be able to explore and interact with their environment. Now, researchers have developed a device that allows amputees to sense and respond to temperature by delivering thermal information from the prosthesis' fingertip to the amputee's residual limb.

9 Feb 2024

Breakthrough technique unveils secrets of "backtracking" in gene regulation

A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study shows.

9 Feb 2024

Large Language Models promise to revolutionize neuroscience research

The past year has seen major advances in Large Language Models (LLMs) such as ChatGPT. The ability of these models to interpret and produce human text sources (and other sequence data) has implications for people in many areas of human activity.

9 Feb 2024

Rucaparib and its major metabolite exhibit differential biological activity and synergy

Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion.

9 Feb 2024

AI tool maps protein function in tumors, paving way for personalized cancer treatment

Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumor, enabling clinicians to decide how to target treatment in a more precise way.

9 Feb 2024

DDT exposure found to alter sperm epigenome in humans

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.

9 Feb 2024

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease

Drugs commonly used to treat erectile dysfunction may reduce the risk of Alzheimer's disease, finds a new study led by UCL researchers.

9 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

New cervical cancer detection method promises to reduce unnecessary screenings

The BMC Medicine study introduces the CerMe detection method, using PCDHGB7 hypermethylation to effectively triage high-risk HPV-positive women, potentially reducing unnecessary colposcopy referrals.

8 Feb 2024

New mouse model illuminates lung cancer's transformation into aggressive variant

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.

8 Feb 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

New MRI method enables early detection and better monitoring of multiple sclerosis

Multiple sclerosis (MS) is a neurological disease that usually leads to permanent disabilities. It affects around 2.9 million people worldwide, and around 15,000 in Switzerland alone.

8 Feb 2024

Higher dietary niacin intake linked to lower COPD risk, study finds

Recent research in Scientific Reports reveals a dose-response relationship between dietary niacin intake and reduced prevalence of chronic obstructive pulmonary disease (COPD), suggesting niacin's potential role in mitigating oxidative stress and inflammation in COPD patients.

8 Feb 2024

Cell News and Research

Drug repurposing study finds lonafarnib effective against RSV

New study finds 4’-fluorouridine effective against avian influenza in vitro and in vivo

Unlocking Alzheimer's secrets: Study pinpoints APOE4's harmful effect on lipids

Immune system in the blood of Alzheimer's patients found to be epigenetically altered

Sleep apnea prevalent among cardio-oncology patients, study shows

Scientists develop safer CAR T-cell strategy for treating lymphomas

Amputees regain temperature sensation with new prosthetic technology

Breakthrough technique unveils secrets of "backtracking" in gene regulation

Large Language Models promise to revolutionize neuroscience research

Rucaparib and its major metabolite exhibit differential biological activity and synergy

AI tool maps protein function in tumors, paving way for personalized cancer treatment

DDT exposure found to alter sperm epigenome in humans

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

New cervical cancer detection method promises to reduce unnecessary screenings

New mouse model illuminates lung cancer's transformation into aggressive variant

Decoding the differences between two vital RNA transport complexes

Never-before-documented genetic disorder causes rare lung disease

New MRI method enables early detection and better monitoring of multiple sclerosis

Higher dietary niacin intake linked to lower COPD risk, study finds

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