The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil (Aricept) reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Donepezil (Aricept) is the most prescribed Alzheimer's disease therapy worldwide.
The Alzheimer’s Society has expressed serious concern at the interpretation of a new study into the effectiveness of drugs for dementia, published in The Lancet.
Georgetown University Medical Center researchers today opened a new clinical trial designed to test if huperzine A, a natural product derived from a Chinese herb, can slow down or prevent cognitive decline in patients with mild to moderate Alzheimer’s Disease (AD).
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