Glycolysis News and Research

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Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation of both aerobic and anaerobic cellular respiration. It takes place in the cytosol of a cell and is the foundation of both aerobic and anaerobic cellular respiration.

RNA enzyme found key to heart cell energy shift after birth

Researchers investigate the influence of Mettl1 on energy metabolism and the maturation of heart cells after birth.

29 Nov 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function in patients with pre-existing chronic liver disease.

8 Nov 2024

Study sheds new light on p53 tumor suppressor gene's role in ulcerative colitis

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis.

26 Oct 2024

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Research shows Fc–IL-4 revitalizes exhausted CD8+ T cells, boosting antitumor responses and highlighting the potential of combining type 1 and type 2 immunity.

30 Sep 2024

Novel approach combines glutaminase and HuR blockade to suppress breast cancer growth

A study led by Brazilian researchers and reported in an article published in the journal Nature Communications proposes that simultaneously targeting the enzyme glutaminase and the protein HuR, both of which are essential to tumor progression, may be effective in treating breast cancer.

27 Sep 2024

Study reveals positive correlation between type 2 immunity and long-term cancer remission

Results from a preclinical study in mice, led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response – associated with parasitic infection and thought to play a negative role in cancer immunity – is positively correlated with long-term cancer remission.

26 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Disrupted glucose transport in oligodendrocytes linked to myelin thinning and aging in new research

This study uncovers how oligodendroglial lipid metabolism supports myelin homeostasis and axonal function under metabolic stress, crucial for neurodegeneration.

11 Sep 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells - which confer lasting immunity to previously encountered pathogens - and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

Study highlights benefits of exercise for both men and women

Females' and males' muscles differ in glucose and fatty acid handling – but regular physical activity quickly triggers similar beneficial metabolic changes in the muscles of both sexes, new research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9-13 September) has found.

16 Aug 2024

EZH2's role in cancer progression and therapy explored

Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of the Polycomb-repressive complex 2 (PRC2), which plays a crucial role in transcriptional repression through the methylation of histone H3 on lysine 27 (H3K27me3).

9 Aug 2024

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

With a new $11.3 million Program Project grant from the National Institutes of Health, experts from the Vascular Biology Center at the Medical College of Georgia at Augusta University are working to better understand the underlying mechanisms of cardiovascular disease.

8 Aug 2024

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by modulating gut microbiota.

23 Jul 2024

Mitochondrially-targeted antioxidants could reduce SARS-CoV-2 effects across multiple organs

Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children's Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.

15 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024

New Approach to Treating Melanoma

An international research team, led by Professor Wenbo Bu of Fudan University and Distinguished Professor Dayong Jin of the University of Technology Sydney, have discovered an innovative method to effectively treat cancer by reactivating suppressed metabolic pathways in cancer cells.

20 Jun 2024

Glycolysis News and Research

Further Reading

RNA enzyme found key to heart cell energy shift after birth

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Study sheds new light on p53 tumor suppressor gene's role in ulcerative colitis

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Novel approach combines glutaminase and HuR blockade to suppress breast cancer growth

Study reveals positive correlation between type 2 immunity and long-term cancer remission

Researchers gain new understanding of how immune cells respond to heat during fever

Disrupted glucose transport in oligodendrocytes linked to myelin thinning and aging in new research

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

Study highlights benefits of exercise for both men and women

EZH2's role in cancer progression and therapy explored

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Mitochondrially-targeted antioxidants could reduce SARS-CoV-2 effects across multiple organs

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

New Approach to Treating Melanoma

New technique uses nutrients to effectively treat cancer

Study uncovers key biological pathways driving psoriasis inflammation

Ketogenic diet boosts mental health: Study reveals reduced stress and improved mood

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