Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

6 Sep 2024

Scientists reveal how DNA methylation drives astrocytes to become stem cells, unlocking new potential for brain repair

Researchers have discovered that DNA methylation is crucial for reprogramming astrocytes into stem cells in the adult mouse brain, especially after ischemic injury, with potential implications for regenerative medicine.

6 Sep 2024

SARS-CoV-2 evolves differently in the brain, revealing critical insights into viral tropism

Study investigates the evolution of SARS-CoV-2 within the central nervous system (CNS) compared to the lungs in mice, revealing higher viral divergence in the CNS and highlighting the critical role of the furin cleavage site (FCS) in viral tropism and compartmentalization.

27 Aug 2024

CDC study reveals critical gaps in hantavirus detection across the U.S. due to inconsistent testing standards

Researchers map the prevalence and genotype distribution of hantavirus in the U.S., highlighting significant regional differences and the need for standardized testing

25 Aug 2024

New $5.8 million grant aims to transform the global landscape of TB research

A $5.8 million grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, or AHRI, in Durban, South Africa, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.

23 Aug 2024

Histopathologic features of immune checkpoint inhibitor-induced myocarditis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Recent advancements in immunotherapy have substantially improved overall survival and quality of life among patients with cancer.

6 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

AI model Virchow outperforms clinical methods in cancer detection

In a recent study published in Nature Medicine, researchers demonstrated the use of the foundational model Virchow for computational analysis of pathological reports, prediction of biomarkers, and identification of cells across multiple cancer types. Virchow's pan-cancer model showed impressive accuracy, often outperforming clinical-grade models.

23 Jul 2024

Deciphering the role of RET in cancer and breakthroughs in targeted treatments

Xueqing Hu , Ujjwol Khatri , Tao Shen , and Jie Wu, at University of Oklahoma Health Sciences Center, USA, provides a comprehensive review of the role of the RET (REarranged during Transfection) receptor tyrosine kinase in cancer development and the advancements in RET-targeted cancer therapies.

19 Jul 2024

Study finds dairy cows vulnerable to flu strains from birds, humans, and pigs

Researchers compared the distribution of sialic acid receptors in the respiratory tract and mammary glands of dairy cattle naturally infected with the highly pathogenic avian influenza A(H5N1) virus.

18 Jul 2024

New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Researchers identified distinct hindbrain GLP1R neurons driving satiety and aversion, offering new targets for effective, side-effect-free obesity treatments.

14 Jul 2024

Researchers identify shared molecular mechanism in cancer and pregnancy that suppresses immune system

Researchers elucidated the shared immune tolerance mechanisms in cancer and pregnancy, focusing on the role of an immune checkpoint protein as an onco-fetal immune tolerance checkpoint.

11 Jul 2024

Bird flu virus detected in Alaskan polar bear

Researchers reported a natural infection of a highly pathogenic avian influenza A(H5N1) virus in a free-ranging juvenile polar bear in Alaska, highlighting the importance of wildlife health surveillance in detecting emerging pathogens.

2 Jul 2024

AI identifies new high-risk subtype in endometrial cancer

An AI tool to classify histopathological images and differentiate between endometrial cancer subtypes.

28 Jun 2024

Causal variant-targeted ribonucleic acid treatment for congenital melanocytic nevi

A genetic treatment targeting the causal NRAS c.181C>A mutation in congenital melanocytic naevus.

19 Jun 2024

New WHO classification of kidney tumors integrates molecular diagnostics

Renal tumor pathology has evolved considerably, expanding from two main types of renal malignant tumors to over 20 distinct types.

18 Jun 2024

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).

6 Jun 2024

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Researchers found that young bone marrow transplants rejuvenate aging immune cells, reducing Alzheimer's symptoms in mice models, suggesting a potential therapeutic approach for the disease.

4 Jun 2024

IgG from long COVID patients induces specific symptoms in mice, confirming autoimmunity's role

Researchers found that IgG from long COVID patients induces specific symptoms in mice, suggesting IgG's role in long COVID pathogenesis.

3 Jun 2024

Microplastics: Invisible to the eye but severely harmful to pregnancy and metabolic outcomes

The effects of polystyrene microplastics on pregnancy outcomes and glucose metabolism.

29 May 2024