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Pioneering technique maps the proteome of individual cardiomyocytes

Two research teams at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have developed a pioneering technique in Spain to characterize the proteome of individual cardiomyocytes-the cells responsible for heart contraction.

24 Jun 2026

MSU researchers develop tool to observe complex molecular choreography in real time

A lot of things need to go right on a molecular level for immune cells to launch an adaptive response to an infection.

23 Jun 2026

Scientists trace cardiac aging to a fading regulator in heart muscle cells

Researchers mapped 442,239 single nuclei from nonfailing human hearts to chart how cardiac cells change from fetal development to older adulthood. The study identified PRDM16 as an age-declining cardiomyocyte regulator, with experimental evidence showing that restoring Prdm16 in aged mouse hearts improved systolic function and partly reversed aging-associated transcriptional patterns.

22 Jun 2026

GATA6 loss transforms colorectal cancer cells into metastatic states

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology researchers.

22 Jun 2026

New study reveals cause of chronic inflammation with age

A new study led by researchers at The University of Texas MD Anderson Cancer Center has uncovered a previously unknown connection between nucleic acid structures called R-loops and age-related inflammation – or inflammaging – that could herald new intervention options for chronic inflammation and the subsequent health conditions.

16 Jun 2026

Lysosomal protein stabilizes mitochondria to prevent severe heart failure

A new study published in Engineering has uncovered a regulatory mechanism linking lysosomal function to mitochondrial stability in pathological cardiac hypertrophy, identifying transient receptor potential mucolipin 1 (TRPML1) as a key protective factor against the progression to heart failure.

16 Jun 2026

Cerebellar structural changes influence social behavior in autism

Researchers at Kanazawa University have identified a previously unrecognized mechanism by which structural changes in the cerebellum influence social behavior.

12 Jun 2026

ChatGPT fills gaps like a confabulator, not a hallucinating mind

A Perspective article argues that large language model errors more closely resemble confabulations, while speech recognition errors, such as unsupported Whisper transcriptions, are functionally closer to hallucinations. The authors stress that these parallels are behavioral and provisional, not evidence of shared consciousness, and suggest that psychiatric concepts could help improve AI reliability.

11 Jun 2026

Amsterdam UMC researchers overturn long-standing biological pacemaker dogma

Researchers from Amsterdam UMC have overturned a key assumption in the biological pacemaker field.

11 Jun 2026

Circadian clock protein BMAL1 enhances inflammatory responses in immune cells

Daily life is shaped by the solar day, influencing when we wake up, eat, work, and sleep. Inside the body, a similar internal timing system -present in nearly every cell- known as the circadian clock, synchronizes many biological functions such as sleep, metabolism, hormone release, and even the immune system's activity.

11 Jun 2026

Why Andes hantavirus is not the next COVID-19

Research highlights fundamental differences between Andes hantavirus and SARS-CoV-2, emphasizing distinct transmission routes and public health implications.

10 Jun 2026

New study frames altered protein modifications as cancer drivers

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

9 Jun 2026

Ancient Y chromosome gene UTY retains regulatory function in humans

The study, published in Volume 153, Issue 9 of the journal Development on May 14, 2026, by The Company of Biologists, is the first to precisely map endogenous UTY occupancy across the human genome and demonstrate that UTY remains functionally involved in transcriptional regulation during early human development.

5 Jun 2026

Bee-derived propolis shows potent antiviral activity against varicella-zoster virus

Announcing a new article publication for Zoonoses journal. Varicella-zoster virus (VZV) is a clinically important human neurotropic herpesvirus that causes varicella (chickenpox) as primary infection, typically in children.

5 Jun 2026

Novel technology maps single-cell DNA-protein interactions

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

4 Jun 2026

Vaping devices and flavors affect genes differently

Vaping exposure affects gene activity in the mouth, with variations linked to device type and flavor, suggesting unique molecular responses compared to smoking.

4 Jun 2026

Three-drug strategy forces pancreatic tumors into lasting regression

A triple-targeted preclinical therapy combining daraxonrasib, afatinib, and SD36 drove durable pancreatic cancer regression by blocking KRAS/RAS, EGFR/HER2, and STAT3 signaling. The approach prevented treatment resistance across mouse and human tumor-derived models, but remains preclinical and requires more clinically suitable drug combinations before human testing.

2 Jun 2026

New blood test tracks real time gene expression inside living brain tissue

Cell function is determined by how DNA is expressed into proteins. That process includes two main steps - transcription, when messenger RNA (mRNA) makes copies of active genes, and translation, when mRNA guides protein assembly.

2 Jun 2026

Hypoxia-gated AAV enables targeted treatment for advanced NSCLC

Adeno‑associated virus (AAV) vectors offer safety and durable expression but lack tumor specificity. This hypothesis proposes an NSCLC‑directed, hypoxia‑responsive AAV platform that integrates MGS4 peptide‑guided capsid targeting with dual hypoxia‑responsive element (HRE)‑gated promoters driving Q‑CXCL9‑Fc (chemokine) and miR‑30‑based shRNA against mesothelin (MSLN).

1 Jun 2026

Mesenchymal drift may explain how aging cells lose their identity

Mesenchymal drift may help explain how cells lose stable identity and acquire pro-fibrotic, inflammatory mesenchymal traits during aging. The review proposes MD as a unifying framework that links multiple hallmarks of aging and highlights partial reprogramming as a potential, but still preclinical, way to counteract this process.

1 Jun 2026