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Immune cells in overdrive: Study finds unbalanced response worsens lung infections

CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections.

8 Feb 2024

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA - a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

8 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

A new research perspective was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma."

8 Feb 2024

Enzyme released by immune cells may play role in depression

Mount Sinai researchers have shown for the first time that immune cells called monocytes, derived in the bone marrow and released into the bloodstream, can be drawn during stress into sites in the brain that control emotional behaviors.

8 Feb 2024

New immunotherapy borrows cancer's tricks to unleash powerful T cells

Immunotherapies using engineered T cells have ushered in a new era in cancer treatment, but they have their limits. They may cause side effects or stop working, and they do not work at all against 90% of cancers.

8 Feb 2024

Study advances search for a blood test to identify disease-associated changes in the brain

Researchers in a Johns Hopkins Children's Center-led study that used genetic material from human blood and lab-grown brain cells say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.

8 Feb 2024

Study discovers a direct connection between the brain and its surrounding environment

In a recent study of the brain's waste drainage system, researchers from Washington University in St. Louis, collaborating with investigators at the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institute of Health (NIH), discovered a direct connection between the brain and its tough protective covering, the dura mater.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

7 Feb 2024

New treatment target found for CDKL5 deficiency disorder

Scientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most common types of genetic epilepsy.

7 Feb 2024

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

AMG 133, an engineered bispecific molecule, demonstrated significant weight loss with a favorable safety profile in a phase 1 clinical trial, offering a promising new treatment option for obesity.

7 Feb 2024

Smoking triggers red blood cell death, raising anemia and circulation concerns

Smoking significantly increases suicidal erythrocyte death, potentially leading to anemia and microcirculation issues, despite showing no adverse effects on overall red blood cell indices.

7 Feb 2024

Experimental mRNA vaccine against CMV elicits promising immune responses

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

7 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024

Mitochondria on the move: New discovery could revolutionize treatment of brain diseases

The human brain is an organ that takes nearly from 20 to 25% of the energy the body needs. This high energy demand for neuronal functions depends on the transport and precise distribution of mitochondria — the energy-generating cell organelles — in each neuron.

7 Feb 2024

Odors stimulate specific brain cells involved in rapid decision making

Researchers at the University of Colorado Anschutz Medical Campus have discovered that odors stimulate specific brain cells that may play a role in rapid `go, no-go' decision making.

7 Feb 2024

Immune cell networks key to success of personalized cancer treatment

Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are likely to respond to a personalized immunotherapy known as adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL).

7 Feb 2024

Researchers identify a new approach to controlling bacterial infections

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections.

7 Feb 2024

Cell News and Research

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

Mitochondrial misfire sparks inflammation

New drug targets key mechanism in ALS, protects motor neurons

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

Enzyme released by immune cells may play role in depression

New immunotherapy borrows cancer's tricks to unleash powerful T cells

Study advances search for a blood test to identify disease-associated changes in the brain

Study discovers a direct connection between the brain and its surrounding environment

Monash-led study unveils potential long-term treatment for lupus

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

New treatment target found for CDKL5 deficiency disorder

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

Smoking triggers red blood cell death, raising anemia and circulation concerns

Experimental mRNA vaccine against CMV elicits promising immune responses

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Mitochondria on the move: New discovery could revolutionize treatment of brain diseases

Odors stimulate specific brain cells involved in rapid decision making

Immune cell networks key to success of personalized cancer treatment

Researchers identify a new approach to controlling bacterial infections

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