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Researchers identify biomarkers associated with bacterial infection mortality

David Gonzalez's "a-ha" moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient.

4 Sep 2020

CRISPR-based system suppresses genes related to AAV antibody production

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body's immune response to AAV can thwart the whole endeavor.

4 Sep 2020

New consortium established to study the characteristics of blood cells

What's the risk of different human populations to develop a disease? To find out, a team led by Université de Montréal professor Guillaume Lettre created an international consortium to study the blood of hundreds of thousands of people worldwide.

4 Sep 2020

New training system uses IoT to motivate and track exercise intensity levels

A common notion is to walk 10,000 steps a day to improve ones' physical fitness, so pedometers have been a popular wearable health device from before the days of fitness trackers and smartphones.

3 Sep 2020

Understanding mechanisms in prostate cancer metastases can provide treatment opportunities

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer.

3 Sep 2020

Research provides a map of coronavirus entry factors across the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases and Cornell University in the US have investigated cellular factors that could be significant for an infection.

3 Sep 2020

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

Researchers at the Icahn School of Medicine at Mount Sinai, New York, have conducted a study that sheds light on the molecular underpinnings of multisystem inflammatory syndrome in children (MIS-C).

3 Sep 2020

Researchers develop new model to predict survival in colorectal cancer

Colorectal cancer (CRC) is the third most common cancer among women and men in the USA, and recent studies have shown an increasing incidence in less developed regions, including Sub-Saharan Africa (SSA).

3 Sep 2020

Scientists identify genetic risk factors underlying penicillin allergy

Penicillin, a life-saving medicine, is the most common cause of drug allergy, with clinical manifestations ranging from temporary skin reactions to life-threatening systemic syndromes.

3 Sep 2020

Study shows what happens in the fetal brain affected by congenital Zika syndrome

Zika virus infection during pregnancy can cause severe abnormalities in the fetus, including malformations such as microcephaly.

3 Sep 2020

Genomic analysis of specific E. coli strain can help develop potential vaccines

Foodborne pathogens are very common and usually benign, but certain virulent strains of pathogens can result in severe disease and even death.

3 Sep 2020

Trinity College researchers to participate in gene-based clinical trial for motor neuron disease

Researchers at Trinity College Dublin are to participate in an early phase gene-based clinical trial for motor neuron disease (MND). The research team represents one of only four centres in Europe to take part in such an exciting clinical trial for this devastating disease.

2 Sep 2020

Scientists aim to find cortisone alternatives with fewer side effects

Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19.

2 Sep 2020

Study offers a possible explanation for prevalence of autism spectrum disorder

Recent estimates indicate a prevalence of autism spectrum disorder (ASD) in the United States of 1 in 59 children with a well-established 4:1 male predominance.

2 Sep 2020

Study: BIRC2 overexpression could be a key marker for immunotherapy resistance

Johns Hopkins Medicine researchers have added to evidence that a gene responsible for turning off a cell's natural "suicide" signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer.

2 Sep 2020

ACE2/TMPRSS2 not expressed in pancreatic islet endocrine cells

A new study by researchers at the Vanderbilt University Medical Center and the University of Pennsylvania Perelman School of Medicine and published on the preprint server bioRxiv* in August 2020 reports that both key enzymes that are required for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the human host cell are lacking in the beta cells of the pancreatic islet. This rules out the direct injury hypothesis for impaired glucose control in patients with COVID-19 disease.

1 Sep 2020