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Study shows brain estrogen directly regulates appetite in mice

Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces body weight in mice by enhancing MC4R expression. The study also showed that neuroestrogen boosts leptin sensitivity, suggesting new targets for obesity treatment.

2 May 2025

Retinal exams show promise for early detection of Parkinson's disease

Could it be possible to diagnose Parkinson's disease with the help of a simple retinal exam? The idea should be seriously considered, according to a study published in the May issue of Neurobiology of Disease by researchers from Université Laval who discovered that the retina of people with Parkinson's disease responds differently to light stimuli than that of healthy people.

1 May 2025

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's blood vessels.

30 Apr 2025

Study links impaired synaptic pruning to autism

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of behavior or interests.

30 Apr 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

Machine learning provide new insights into how the brain responds to heroin use

Object recognition software is used by law enforcement to help identify suspects, by self-driving cars to navigate roadways and by many consumers to unlock their cell phones or pay for their morning coffee.

30 Apr 2025

Dopamine circuit helps the brain unlearn fear

Dangers come but dangers also go and when they do, the brain has an "all-clear" signal that teaches it to extinguish its fear.

28 Apr 2025

Researchers discover dual role of sleep in memory formation

Memory formation, storage, and retrieval are fundamental processes that define who we are and how we interact with the world.

28 Apr 2025

Study illuminates a general principle of neural processing in the brain’s serotonin system

Our lives are filled with binary decisions – choices between one of two alternatives. But what's really happening inside our brains when we engage in this kind of decision making?

25 Apr 2025

Brain stimulation at 40Hz boosts memory and neurogenesis in Down syndrome mice

Study provides new evidence that sensory stimulation of gamma-frequency brain rhythm may promote broad-based restorative neurological health response.

25 Apr 2025

Mouse study confirms early inflammation in hereditary paralysis condition

A joint study conducted by the University of Bonn and the DZNE has confirmed early-stage brain inflammation in mice.

25 Apr 2025

NIH study reveals how inflammation affects pain perception

Researchers uncover the cellular and molecular basis for sensing heat and inflammatory pain.

24 Apr 2025

New approach may prevent neurotoxic protein aggregates in ALS

Researchers at Goethe University, Johannes Gutenberg University Mainz and Kiel University discover possible method for preventing protein aggregates – Cluster4Future PROXIDRUGS research project.

23 Apr 2025

Single psychedelic dose boosts long-term cognitive flexibility in mice

University of Michigan researchers have found that certain psychedelic compounds improve the brain’s ability to adapt and flexibly learn new concepts over long periods.

22 Apr 2025

Mayo Clinic study reveals brain cell deficit behind Tourette syndrome

A new Mayo Clinic study finds that people with Tourette syndrome have about half as many of a specific type of brain cell that helps calm overactive movement signals as people without the condition.

22 Apr 2025

New treatment approach offers hope for people with primary progressive aphasia

Primary progressive aphasia is a neurological condition that causes a gradual decline in language abilities.

21 Apr 2025

iPS cell transplants show early promise for treating Parkinson's disease safely

In a first-of-its-kind human trial, researchers transplanted iPS-cell-derived dopaminergic progenitors into patients with Parkinson’s disease and observed promising motor improvements with no serious safety concerns over 24 months. The therapy showed increased dopamine synthesis without tumor formation or graft-induced dyskinesia.

21 Apr 2025