Phenotype News and Research

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Study reveals new mechanism involved in the pathogenesis of IBD

Inflammatory bowel disease is a category of refractory inflammatory disease, of which ulcerative colitis and Crohn's disease are the main types.

21 Jan 2020

How SpatialOMx is Delivering New Insights into Disease Research

An interview with Shannon Cornett Ph.D, discussing the use of MALDI-guided spatial molecular analysis for biomarker discovery.

From Bruker Life Sciences Mass Spectrometry 14 Jan 2020

The International Consortium Claims Medical Breakthrough in Malaria Research

An international consortium led by researchers in Sweden and Switzerland has conducted a genome-wide study that the team is calling a “medical breakthrough” in malaria research.

13 Jan 2020

Harnessing biology and technology to develop much-needed treatments for depression

New research into the biology of depression, along with new and evolving technologies, provides the basis for developing the next generation of treatments for major depressive disorder, according to the special January/February issue of Harvard Review of Psychiatry.

9 Jan 2020

Pathios appoints Stuart Hughes as CEO and announces US$8.8M Series A financing round

Pathios Therapeutics Limited, an innovative biotech company focused on the development of first-in-class therapies for autoimmune diseases and cancer, today announced a US$8.8M Series A financing round with leading international healthcare investors Canaan and Australia’s Medical Research Commercialization Fund managed by Brandon Capital.

9 Jan 2020

Post-mortem genetic testing used to find underlying cause of sudden deaths in Amish families

Researchers used post-mortem genetic testing to find the underlying cause of multiple sudden deaths in young people and sudden cardiac arrests in two large Amish families.

8 Jan 2020

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment.

8 Jan 2020

Dog study suggests that AAV in gene therapy could induce cancer

A gene therapy study in dogs has stirred up old fears that by using AAV in gene therapy, it may be increasing cancer chances.

8 Jan 2020

Study on chimpanzees shows maternal presence, maternal social status can impact offspring

The prolonged periods of juvenility and nutritional dependence that are characteristic of human development are thought to facilitate brain and somatic growth in children, as well as provide opportunities to learn and accumulate skills required for a productive adult life. In chimpanzees, the benefits of continuing to associate with mothers after becoming nutritionally independent are less well understood.

7 Jan 2020

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

It seems that chewing gum is not a new trend! Researchers have found chewing gum that is 5,700 years old and it has provided clues regarding ancient DNA. A study with the findings was published in the journal Nature Communications. It is titled, “A 5,700-year-old human genome and oral microbiome from chewed birch pitch.”

18 Dec 2019

Social and visual neural networks do not connect in some children with autism

Among the first and most-documented symptoms of autism spectrum disorder is a child's aversion to interaction with others. Specifically, they appear uninterested in social activities and stimuli that would normally attract a young child's attention, such as watching other children play, sing or dance.

17 Dec 2019

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes.

13 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Kanazawa University researchers describe genetic typing of Pseudomonas putida

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p. -- the ability of the bacterium to infect its host and inflict a disease -- is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs.

6 Dec 2019

NeutroCure project aims to cure inflammatory disease with neutrophils

Curing disease with neutrophils; this is the goal of the NeutroCure project. How will that work? "Neutrophils have a yin yang character," explained Andrés Hidalgo, whose team at the Centro Nacional de Investigaciones Cardiovasculares is one of six member groups participating in this project coordinated by Andriy Mokhir Friedrich from Alexander University, Germany.

5 Dec 2019

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Researchers at the Lady Davis Institute have identified a key protein that is required for resistance to chemotherapy in the most aggressive form of breast cancer. This holds the promise of opening the door to new therapies for overcoming drug resistance.

2 Dec 2019

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

Daughters of women with polycystic ovarian syndrome are five times more likely to be diagnosed with PCOS as adults, and the generational transmission is driven by high androgen levels during pregnancy, researchers at Karolinska Institutet in Sweden report.

2 Dec 2019

Phenotype News and Research

Study reveals new mechanism involved in the pathogenesis of IBD

How SpatialOMx is Delivering New Insights into Disease Research

The International Consortium Claims Medical Breakthrough in Malaria Research

Harnessing biology and technology to develop much-needed treatments for depression

Pathios appoints Stuart Hughes as CEO and announces US$8.8M Series A financing round

Post-mortem genetic testing used to find underlying cause of sudden deaths in Amish families

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

Dog study suggests that AAV in gene therapy could induce cancer

Study on chimpanzees shows maternal presence, maternal social status can impact offspring

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

Social and visual neural networks do not connect in some children with autism

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Kanazawa University researchers describe genetic typing of Pseudomonas putida

NeutroCure project aims to cure inflammatory disease with neutrophils

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

New molecular mechanism involved in the regulation of cholesterol movement in cells found

Exploring the link between macular degeneration and retinitis pigmentosa

FDA-approved drug to prevent organ rejection may slow skin aging

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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