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New method for analyzing intact tumor samples to be used for studying COVID-19

Researchers at Karolinska Institutet in Sweden have developed a new method for analyzing intact tumor samples in 3D on a molecular level.

29 Jun 2020

Antibiotic resistance genes tend to persist in E. coli through 'genetic capitalism'

We have known for some time that over-use of antibiotics is causing a frightening increase in antibiotic resistance in bacteria, through the rapid spread of antibiotic resistance genes.

29 Jun 2020

Study unravels CNL6 mystery in Batten disease

Batten disease is a family of 13 rare, genetically distinct conditions. Collectively, they are the most prevalent cause of neurodegenerative disease in children, affecting 1 in 12,500 live births in the U.S. One of the Batten disease genes is CLN6.

29 Jun 2020

Scientists discover osmotic stress as stimulator of cellular waste disposal

Cellular waste disposal, where autophagy and lysosomes interact, performs elementary functions, such as degrading damaged protein molecules, which impair cellular function, and reintroducing the resulting building blocks such as amino acids into the metabolic system.

29 Jun 2020

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).

29 Jun 2020

Study shows how gut bacteria helps people resist cholera

Cholera can kill within hours if left untreated, and it sickens as many as 4 million people a year. In a new article in the journal Cell, researchers describe how gut bacteria helps people resist the disease.

29 Jun 2020

Raw milk can hold huge amount of antimicrobial-resistant genes

Raw or unpasteurized cows' milk from U.S. retail stores can hold a huge amount of antimicrobial-resistant genes if left at room temperature, according to a new study from researchers at the University of California, Davis.

29 Jun 2020

Remodeling may make neurons more prone to Alzheimer's disease

Neurons that regularly remodel are more prone to Alzheimer's disease and die when that remodeling goes awry, a new study suggests. The work is the first to track the progression of Alzheimer's at the genetic and molecular levels within neurons vulnerable to the disease.

29 Jun 2020

NUS researchers discover protein that promotes cancer progression

Cancers arise when the genetic code of normal cells is altered, causing excessive growth. Researchers from the Cancer Science Institute of Singapore at the National University of Singapore have discovered a protein that drives the growth of cancers of the esophagus or liver by altering the genetic code in a novel way.

29 Jun 2020

Researchers develop new atlas for mapping brain regions

In a new study researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have developed a new kind of brain atlas based on an innovative method of mapping brain tissue into areas according to their molecular profile

29 Jun 2020

New model helps study human hippocampal neurons

Neuroscientists and stem cell researchers at Lund University in Sweden have developed a research model that allows studying human hippocampal neurons, the brain cells primarily affected by Alzheimer's disease pathology.

29 Jun 2020

Smart MRI scan used for heart disease can help assess aggressive cancers in children

A type of smart MRI scan used in people with heart disease could help assess whether children's cancers are especially aggressive and spot early signs that targeted treatments are working, a new study suggests.

29 Jun 2020

Similarities between coronaviruses and human genes promote infection

A new study published on the preprint server bioRxiv* in June 2020 shows that the proportion of A/T pairing in viral genomes may increase the tendency to infect humans because of the matching molecular features in some host genes, that increases the susceptibility of the host to the virus.

28 Jun 2020

Genomics used to trace origin of SARS-CoV-2 in Canada

A new study published in June 2020 on the preprint server bioRxiv discusses the use of phylogenetic analysis to trace the origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its spread into and then within Canada. The study findings may help optimize public health policies in the case of future outbreaks.

28 Jun 2020

Towbin receives NIH grant to study modifier genes in cardiomyopathy

Jeffrey A. Towbin, MD, of Le Bonheur Children's Hospital and the University of Tennessee Health Science Center was awarded a Research Project Grant (R01) from the National Institutes of Health with co-principal investigators Enkhsaikha Purevjav, MD, PhD and Lu Lu, MD, MS.

26 Jun 2020

Study reveals colorectal cancer hotspots in the United States

Over the last three decades, colorectal cancer survival in the United States has improved significantly. But in young people--particularly men diagnosed with colorectal cancer before age 50--incidence and mortality due to colorectal cancer are on the rise.

26 Jun 2020